GB764547A - Improvements relating to the depolymerization of high molecular weight dextran - Google Patents
Improvements relating to the depolymerization of high molecular weight dextranInfo
- Publication number
- GB764547A GB764547A GB28245/54A GB2824554A GB764547A GB 764547 A GB764547 A GB 764547A GB 28245/54 A GB28245/54 A GB 28245/54A GB 2824554 A GB2824554 A GB 2824554A GB 764547 A GB764547 A GB 764547A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dextran
- irradiated
- molecular weight
- depolymerization
- electrons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
Abstract
Dextran of very high molecular weight is irradiated with high energy electrons to yield depolymerized dextran having, for example, a molecular weight ranging between 25,000 and 100,000, suitable for clinical use. The energy of the electrons may range from 50,000 to 20 million electron volts. The dextran may be irradiated with 106 to 108, preferably 107, Roentgen units in a polyethylene container sterilization of the dextran and cross-linking of the polyethylene taking place simultaneously with depolymerization of dextran. The dextran may be irradiated in an atmosphere of air, nitrogen, argon, helium, krypton or xenon.ALSO:Dextran of very high molecular weight is irradiated with high energy electrons to yield depolymerized dextran having, for example, a molecular weight ranging between 25,000 and 100,000, suitable for clinical use. The energy of the electrons may range from 50,000 to 20 million electron volts. The dextran may be irradiated with 106 to 108, preferably 107, Roentgen units in a polyethylene container, sterilization of the dextran and cross-linking of the polyethylene taking place simultaneously with depolymerization of dextran. The irradiated dextran may be dissolved in water and a clinically useful fraction may be precipitated by adding methanol, ethanol, propanol or butanol. The dextran may be irradiated in an atmosphere of air, nitrogen, argon, helium, krypton or xenon.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US764547XA | 1953-09-30 | 1953-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB764547A true GB764547A (en) | 1956-12-28 |
Family
ID=22132128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28245/54A Expired GB764547A (en) | 1953-09-30 | 1954-09-30 | Improvements relating to the depolymerization of high molecular weight dextran |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB764547A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3085853A (en) * | 1958-12-23 | 1963-04-16 | Dow Chemical Co | Method of employing dextrans |
-
1954
- 1954-09-30 GB GB28245/54A patent/GB764547A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3085853A (en) * | 1958-12-23 | 1963-04-16 | Dow Chemical Co | Method of employing dextrans |
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