IE38289B1 - 2,7-bis 2-(4-azatricyclo-4,3.1.1. undec-4-yl ethoxy fluoren-9-one and congeners - Google Patents

2,7-bis 2-(4-azatricyclo-4,3.1.1. undec-4-yl ethoxy fluoren-9-one and congeners

Info

Publication number
IE38289B1
IE38289B1 IE1729/73A IE172973A IE38289B1 IE 38289 B1 IE38289 B1 IE 38289B1 IE 1729/73 A IE1729/73 A IE 1729/73A IE 172973 A IE172973 A IE 172973A IE 38289 B1 IE38289 B1 IE 38289B1
Authority
IE
Ireland
Prior art keywords
azatricyclo
undec
congeners
fluoren
ethoxy
Prior art date
Application number
IE1729/73A
Other versions
IE38289L (en
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US00292983A external-priority patent/US3845038A/en
Application filed by Searle & Co filed Critical Searle & Co
Publication of IE38289L publication Critical patent/IE38289L/en
Publication of IE38289B1 publication Critical patent/IE38289B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/24—Camphidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

of formula (I): (where R = 4-azatricyclo- 4,3,1,13,8 - undec-4-yl or 1,8,8-trimethyl-3-azabicyclo 3,2,1 oct-3-yl; alk = 1-7 C alkylene; Z = CH2, CHOH or CO), are useful against viral, bacterial and fungal infections in human and veterinary medicine. Their acute toxicity is lower than that of known interferon-stimulants. [FR2201093A1]
IE1729/73A 1972-09-28 1973-09-27 2,7-bis 2-(4-azatricyclo-4,3.1.1. undec-4-yl ethoxy fluoren-9-one and congeners IE38289B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US00292983A US3845038A (en) 1972-09-28 1972-09-28 2,7-bis(2-(4-azatricyclo(4.3.1.13,8)undec-4-yl)ethoxy)fluoren-9-one and congeners
GB1978873A GB1387388A (en) 1972-09-28 1973-04-26 G d 2,7-bis 2-4-azatricyclo-4.3.1. 3,8- undec-4-yl -ethoxy- fluoren-9-one and congeners

Publications (2)

Publication Number Publication Date
IE38289L IE38289L (en) 1974-03-28
IE38289B1 true IE38289B1 (en) 1978-02-01

Family

ID=26254249

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1729/73A IE38289B1 (en) 1972-09-28 1973-09-27 2,7-bis 2-(4-azatricyclo-4,3.1.1. undec-4-yl ethoxy fluoren-9-one and congeners

Country Status (7)

Country Link
JP (1) JPS4970975A (en)
AR (2) AR199417A1 (en)
AU (1) AU6081373A (en)
DE (1) DE2348534A1 (en)
FR (1) FR2201093A1 (en)
IE (1) IE38289B1 (en)
NL (1) NL7313332A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1110875A (en) * 1993-06-18 1995-10-25 大塚制药株式会社 Fluorenone derivatives, process for preparing the same and central or peripheral nerve degeneration repair and protective agent
US20050171079A1 (en) * 2004-02-04 2005-08-04 Schrimpf Michael R. Amino-substituted tricyclic derivatives and methods of use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL33573A (en) * 1968-12-30 1973-10-25 Richardson Merrell Inc Bis-basic ethers and thioethers of fluorenone,fluorenol and fluorene

Also Published As

Publication number Publication date
DE2348534A1 (en) 1974-04-04
NL7313332A (en) 1974-04-01
FR2201093A1 (en) 1974-04-26
AU6081373A (en) 1975-03-27
AR199417A1 (en) 1974-08-30
AR199986A1 (en) 1974-10-08
JPS4970975A (en) 1974-07-09
FR2201093B1 (en) 1976-08-13
IE38289L (en) 1974-03-28

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