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Expired
Application number
GB8513/54A
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Bayer AG
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Bayer AG
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Publication of GB761091ApublicationCriticalpatent/GB761091A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
The invention comprises 5 : 5-dicrotylthiobarbituric acid and its alkali metal salts. The products are made by (1) condensing an ester of dicrotyl malonic acid with thiourea and an alkali metal alcoholate; (2) by condensing an alkyl ester of dicrotyl-cyano-acetic acid with thiourea and an alkali metal alcoholate to form 4 - imino - 5 : 5 - dicrotyl - thiobarbituric acid which is hydrolysed with concentrated mineral acid; or (3) by sulphurizing 5 : 5-dicrotylbarbituric acid or one of its alkali-metal salts, e.g. by heating with phosphorus pentasulphide in a high boiling inert solvent. Methods (1) and (2) are preferably carried out in methanol, using sodium methylate as the condensing agent. Starting materials. Methyl dicrotyl-cyano acetic acid ester is made by treating methyl cyanoacetic acid ester with crotyl bromide in the presence of sodium methoxide.
GB8513/54A1953-04-011954-03-23Process for the production of thiobarbiturates
ExpiredGB761091A
(en)