GB758224A - Process for the production of diethylaminoaceto-2:6-xylidide - Google Patents

Process for the production of diethylaminoaceto-2:6-xylidide

Info

Publication number
GB758224A
GB758224A GB1923454A GB1923454A GB758224A GB 758224 A GB758224 A GB 758224A GB 1923454 A GB1923454 A GB 1923454A GB 1923454 A GB1923454 A GB 1923454A GB 758224 A GB758224 A GB 758224A
Authority
GB
United Kingdom
Prior art keywords
alkali metal
solvent
prepared
heating
diethylaminoaceto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1923454A
Inventor
Isabella Primrose Smith Hardie
Edward Severin Stern
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
J F Macfarlan & Co Ltd
Original Assignee
J F Macfarlan & Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J F Macfarlan & Co Ltd filed Critical J F Macfarlan & Co Ltd
Priority to GB1923454A priority Critical patent/GB758224A/en
Priority to BE538677A priority patent/BE538677A/en
Publication of GB758224A publication Critical patent/GB758224A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Diethylaminoaceto-2 : 6-xylidide is prepared by condensing 2 : 6-xylidine with an ester N(C2H5)2.CH2.COX, X being an alkoxy group containing 1-6 carbon atoms by heating a common solution of the two reactants in an anhydrous solvent in the presence of an alkali metal, alkali metal amide or alkali metal hydride. The reaction product can be recovered by heating to remove solvent and low-boiling material, treating the residue with water, or with dilute acid followed by subsequent neutralization, and extracting the neutral or alkaline aqueous solutions so formed. Examples illustrate the use of methyl and ethyl diethylamine-acetates as the second reaction component and the use of sodamide, sodium, lithium and lithium hydride as condensing agents, the solvent being benzene or toluene. The picrate of the product is prepared. The Provisional Specification refers also to the use of alkaline condensing agents in general in the process of the invention and states that the presence of an anhydrous solvent is preferred. Specification 706,409 is referred to.
GB1923454A 1954-06-30 1954-06-30 Process for the production of diethylaminoaceto-2:6-xylidide Expired GB758224A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB1923454A GB758224A (en) 1954-06-30 1954-06-30 Process for the production of diethylaminoaceto-2:6-xylidide
BE538677A BE538677A (en) 1954-06-30 1955-06-02 PROCESS FOR THE PRODUCTION OF DIETHYLAMINOACETO-2,6-XYLIDIDE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1923454A GB758224A (en) 1954-06-30 1954-06-30 Process for the production of diethylaminoaceto-2:6-xylidide

Publications (1)

Publication Number Publication Date
GB758224A true GB758224A (en) 1956-10-03

Family

ID=10125944

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1923454A Expired GB758224A (en) 1954-06-30 1954-06-30 Process for the production of diethylaminoaceto-2:6-xylidide

Country Status (1)

Country Link
GB (1) GB758224A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5331012A (en) * 1990-07-30 1994-07-19 Riddick Kenneth B Topical pharmaceutical preparation for fever blisters and other viral infections and method of use
CN105294477A (en) * 2015-11-04 2016-02-03 浙江汇能生物股份有限公司 Method for preparing lidocaine hydrochloride

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5331012A (en) * 1990-07-30 1994-07-19 Riddick Kenneth B Topical pharmaceutical preparation for fever blisters and other viral infections and method of use
CN105294477A (en) * 2015-11-04 2016-02-03 浙江汇能生物股份有限公司 Method for preparing lidocaine hydrochloride

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