GB757339A - Improvements in the recovery of callicrein - Google Patents
Improvements in the recovery of callicreinInfo
- Publication number
- GB757339A GB757339A GB22898/53A GB2289853A GB757339A GB 757339 A GB757339 A GB 757339A GB 22898/53 A GB22898/53 A GB 22898/53A GB 2289853 A GB2289853 A GB 2289853A GB 757339 A GB757339 A GB 757339A
- Authority
- GB
- United Kingdom
- Prior art keywords
- callicrein
- salt
- zinc
- precipitated
- hormone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4853—Kallikrein (3.4.21.34 or 3.4.21.35)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Zinc salts of callicrein are precipitated from an aqueous solution of the hormone at pH 4 to 7 by addition of a solution of a soluble zinc salt e.g. acetate, sulphate, nitrate or chloride, in the presence of a water miscible organic solvent e.g. alcohol, acetone, dioxane, glycol or mixtures thereof, and zinc salt of callicrein recovered from the precipitate by treatment with water or a neutral salt solution e.g. normal saline solution. Callicrein may be obtained by contacting the extract with an ion-exchanger to remove the zinc and precipitating the hormone from the percolate. The zinc salt may be added to the aqueous solution of callicrein, and after separating the precipitated inactive materials, the hormone salt is precipitated by addition of the organic solvent to a concentration of thirty per cent. If the starting material contains a large concentration of inactive material the organic solvent is added before the addition of the zinc salt. Specification 757,095 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE757339X | 1952-08-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB757339A true GB757339A (en) | 1956-09-19 |
Family
ID=6660016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB22898/53A Expired GB757339A (en) | 1952-08-25 | 1953-08-19 | Improvements in the recovery of callicrein |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB757339A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3670075A (en) * | 1969-05-19 | 1972-06-13 | Spofa Vereinigte Pharma Werke | Process of preparing a protease inhibitor |
-
1953
- 1953-08-19 GB GB22898/53A patent/GB757339A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3670075A (en) * | 1969-05-19 | 1972-06-13 | Spofa Vereinigte Pharma Werke | Process of preparing a protease inhibitor |
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