GB752523A - Hydrocortisone production - Google Patents

Hydrocortisone production

Info

Publication number
GB752523A
GB752523A GB22961/54A GB2296154A GB752523A GB 752523 A GB752523 A GB 752523A GB 22961/54 A GB22961/54 A GB 22961/54A GB 2296154 A GB2296154 A GB 2296154A GB 752523 A GB752523 A GB 752523A
Authority
GB
United Kingdom
Prior art keywords
hydrocortisone
mixture
free solution
substantially oxygen
alkali
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB22961/54A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB752523A publication Critical patent/GB752523A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

Hydrocortisone is obtained by saponifying hydrocortisone acetate by mixing a substantially oxygen-free solution of 11b , 17a -dihydroxy - 21 - acetoxy - 4 - pregnene - 3,20-dione in a lower alkanol with an aqueous substantially oxygen-free solution of at least a molar equivalent, calculated on the hydrocortisone acetate, of an alkali-metal bicarbonate and containing the reaction at a temperature between about 15 DEG to 30 DEG C. while protecting the mixture from atmospheric oxygen, and thereafter neutralizing the saponified mixture with an aqueous solution of an acid, e.g. acetic acid, and isolating the thus-produced hydrocortisone. As alkali metal bicarbonates there may be used sodium potassium or lithium bicarbonate. Preferably neutralization is effected below 30 DEG C.
GB22961/54A 1953-08-13 1954-08-06 Hydrocortisone production Expired GB752523A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US752523XA 1953-08-13 1953-08-13

Publications (1)

Publication Number Publication Date
GB752523A true GB752523A (en) 1956-07-11

Family

ID=22124497

Family Applications (1)

Application Number Title Priority Date Filing Date
GB22961/54A Expired GB752523A (en) 1953-08-13 1954-08-06 Hydrocortisone production

Country Status (1)

Country Link
GB (1) GB752523A (en)

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