GB750359A - Recovery of nitrogenous bases of the morphine series - Google Patents
Recovery of nitrogenous bases of the morphine seriesInfo
- Publication number
- GB750359A GB750359A GB3212153A GB3212153A GB750359A GB 750359 A GB750359 A GB 750359A GB 3212153 A GB3212153 A GB 3212153A GB 3212153 A GB3212153 A GB 3212153A GB 750359 A GB750359 A GB 750359A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alcohol
- morphine
- organic phase
- aqueous
- bases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Nitrogenous bases of the morphine series are extracted from an aqueous phase by means of an organic phase which is a mixture of (1) phenol, an alkylphenol or phenylalkanol containing not more than six carbon atoms in the aliphatic chain; (2) a C3-C6 aliphatic alcohol or an ester derived from a C1-C4 fatty acid and a C1-C6 aliphatic alcohol (organic phase lighter than aqueous) or a C6-C9 aromatic nitro compound or C1-C6 aliphatic nitro compound (organic phase heavier than aqueous); and (3) a diluent miscible with (1) and (2) of S.G. less than 0.9 or greater than 1.2 according to the solvent used for (2), the diluent being in such proportion that the two phases differ in S.G. by 0.10-0.28. The first liquid has a high solvent power for the bases and can be phenol, an alkylphenol, benzyl alcohol or phenethyl alcohol. The second liquid reduces the total solvent power but facilitates phase separation; it may be propanol, isopropanol, a butanol, amyl alcohol, isoamyl alcohol, ethyl acetate, propyl acetate or isopropyl acetate. Specified diluents are petroleum ether, benzene, toluene, xylene, cyclohexane, methyl isobutyl ketone, di-isopropyl ketone, di-isopropyl ether, di-butyl ether, ethylene dichloride, trichlorethylene, chloroform and carbon tetrachloride. Examples are given of the extraction of (1) morphine using cresol +n-butanol+cyclohexane; (2) dihydromorphinone using benzyl alcohol+ethyl acetate +benzene; and (3) morphine using cresol+ nitrobenzene+ethylene dichloride. The process is also applicable to the extraction of dihydromorphine, pseudomorphine, nor - morphine and N-alkyl and N-alkenyl derivatives thereof. The bases are separated from the organic phase by concentration and precipitation with alkali or by extraction with aqueous acid, preferably one of those used in Specification 750,360, e.g. oxalic acid. According to the Provisional Specification the process is applicable to nitrogenous bases of the 3-hydroxyhydrophenanthrene series in general.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3212153A GB750359A (en) | 1953-11-19 | 1953-11-19 | Recovery of nitrogenous bases of the morphine series |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3212153A GB750359A (en) | 1953-11-19 | 1953-11-19 | Recovery of nitrogenous bases of the morphine series |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB750359A true GB750359A (en) | 1956-06-13 |
Family
ID=10333584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3212153A Expired GB750359A (en) | 1953-11-19 | 1953-11-19 | Recovery of nitrogenous bases of the morphine series |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB750359A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6054584A (en) * | 1996-11-19 | 2000-04-25 | The Board Of Regents Of The University And Community College System Of Neveda | Process for extracting and purifying morphine from opium |
-
1953
- 1953-11-19 GB GB3212153A patent/GB750359A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6054584A (en) * | 1996-11-19 | 2000-04-25 | The Board Of Regents Of The University And Community College System Of Neveda | Process for extracting and purifying morphine from opium |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1426018A (en) | Recovery of acids from aqueous solutions | |
| GB750359A (en) | Recovery of nitrogenous bases of the morphine series | |
| GB674754A (en) | Process for recovery of tar acids and bases from hydrocarbon oils | |
| GB936066A (en) | Recovery process | |
| GB986924A (en) | Process for the recovery of tertiary olefins | |
| US2911360A (en) | Removing acids from petroleum | |
| ES309422A1 (en) | Method of extracting saponins | |
| GB1080717A (en) | Purification of crude organic polyisocyanates | |
| GB790658A (en) | Process for removing nitrogenous compounds from hydrocarbon oils | |
| GB1037207A (en) | Improvements in and relating to process for extracting anthracene and carbazol from crude anthracenic oils of coal tars | |
| US1988031A (en) | Method of recovering carotene | |
| US3729541A (en) | Recovery of beryllium | |
| GB650781A (en) | Process for purification of solvents | |
| GB934986A (en) | Refining the liquid hydrogenation products of coal | |
| GB1021709A (en) | Process for the production of pure lactams | |
| GB948307A (en) | Preparation of quinacridone pigments | |
| GB969013A (en) | Separation of components of coal tar fractions | |
| GB1105796A (en) | Method of isolating anthracene, phenanthrene and carbazole from mixtures of the same | |
| Waltman et al. | Electron spin resonance study of the 2-adamantyl radical | |
| GB803366A (en) | Method for separating the constituents of coal-pitch and the like | |
| Henbest et al. | 313. Reactions between quinones and unsaturated amines. Part II. The detection of N-alkylvinylamines in equilibria with ethylideneamines | |
| US2837531A (en) | Extraction of indoles | |
| GB893588A (en) | Recovery of 6-aminopenicillanic acid from aqueous solutions | |
| GB974878A (en) | Process for recovering saponins from agave leaves | |
| GB688747A (en) | Process for the separation of aliphatic alcohols from hydrocarbon-alcohol mixtures |