GB893588A - Recovery of 6-aminopenicillanic acid from aqueous solutions - Google Patents

Recovery of 6-aminopenicillanic acid from aqueous solutions

Info

Publication number
GB893588A
GB893588A GB439460A GB439460A GB893588A GB 893588 A GB893588 A GB 893588A GB 439460 A GB439460 A GB 439460A GB 439460 A GB439460 A GB 439460A GB 893588 A GB893588 A GB 893588A
Authority
GB
United Kingdom
Prior art keywords
acid
aminopenicillanic acid
water
organic solvent
aqueous solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB439460A
Inventor
Frank Ralph Batchelor
George Newbolt Rolinson
Edward Raymond Stove
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Research Laboratories Ltd
Original Assignee
Beecham Research Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Research Laboratories Ltd filed Critical Beecham Research Laboratories Ltd
Priority to GB439460A priority Critical patent/GB893588A/en
Priority to CH114161A priority patent/CH397685A/en
Publication of GB893588A publication Critical patent/GB893588A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position

Abstract

6-aminopenicillanic acid is recovered from aqueous solutions thereof by extracting the aqueous solution with a water-immiscible organic solvent incapable of reaction with 6-amino-penicillanic acid and acylating agents for 6-amino-penicillanic acid, the solvent having dissolved therein one or more secondary amines of the general formula <FORM:0893588/IV (b)/1> wherein R is an aliphatic group containing 10 to 14 carbon atoms and R1, R2 and R3 are each alkyl groups containing a total of 11 to 14 carbon atoms, and separating the organic solvent phase containing the 6-aminopenicillanic acid. The water-immiscible solvent may be chloroform, butyl acetate or kerosene, and the 6-aminopenicillanic acid may be separated and removed from the organic solvent phase, e.g. by extraction with water at a pH of 1 to 3, or the 6-aminopencillanic acid may be acylated in the solvent phase to a penicillin. Specification 870,396 is referred to.
GB439460A 1960-02-08 1960-02-08 Recovery of 6-aminopenicillanic acid from aqueous solutions Expired GB893588A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB439460A GB893588A (en) 1960-02-08 1960-02-08 Recovery of 6-aminopenicillanic acid from aqueous solutions
CH114161A CH397685A (en) 1960-02-08 1961-01-31 Process for the production of penicillins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB439460A GB893588A (en) 1960-02-08 1960-02-08 Recovery of 6-aminopenicillanic acid from aqueous solutions

Publications (1)

Publication Number Publication Date
GB893588A true GB893588A (en) 1962-04-11

Family

ID=9776340

Family Applications (1)

Application Number Title Priority Date Filing Date
GB439460A Expired GB893588A (en) 1960-02-08 1960-02-08 Recovery of 6-aminopenicillanic acid from aqueous solutions

Country Status (2)

Country Link
CH (1) CH397685A (en)
GB (1) GB893588A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048895A1 (en) * 1998-03-20 1999-09-30 Dsm N.V. A process for recovery of 6-aminopenicillanic acid from a mother liquor

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048895A1 (en) * 1998-03-20 1999-09-30 Dsm N.V. A process for recovery of 6-aminopenicillanic acid from a mother liquor
EP0950660A1 (en) * 1998-03-20 1999-10-20 Gist-Brocades B.V. A process for recovery of 6-aminopenicillanic acid from a mother liquor

Also Published As

Publication number Publication date
CH397685A (en) 1965-08-31

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