GB744483A - Manufacture of 4-aminosalicylic acid salts of heterocyclic carboxylic hydrazides andof their complex copper, gold and iron salts - Google Patents
Manufacture of 4-aminosalicylic acid salts of heterocyclic carboxylic hydrazides andof their complex copper, gold and iron saltsInfo
- Publication number
- GB744483A GB744483A GB5247/53A GB524753A GB744483A GB 744483 A GB744483 A GB 744483A GB 5247/53 A GB5247/53 A GB 5247/53A GB 524753 A GB524753 A GB 524753A GB 744483 A GB744483 A GB 744483A
- Authority
- GB
- United Kingdom
- Prior art keywords
- salt
- salts
- gold
- carboxylic acid
- copper
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/86—Hydrazides; Thio or imino analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises 4-aminosalicylic acid salts of heterocyclic carboxylic acid hydrazides and the preparation thereof by reacting 4-aminosalicylic acid, or a salt thereof with an inorganic base, and a heterocyclic carboxylic acid hydrazide, or a salt thereof with an inorganic acid, in an inert liquid medium in which both the reactants are soluble, e.g. alcohol or aqueous alcohol, and allowing the salt to crystallize out. The invention also includes the complex copper, gold and iron salts of the above salts and the preparation thereof by carrying out the above process in the presence of a salt of copper, gold or iron which is soluble in the liquid medium used. The preferred heterocyclic carboxylic acid hydrazide is a pyridine carboxylic hydrazide, e.g. pyridine - 4 - carboxylic acid hydrazide. The complex copper, gold or iron salts may be prepared by adding an aqueous solution of the metal salt to an alcoholic solution of the 4-aminosalicylic acid and the heterocyclic carboxylic acid hydrazide. The metal salt used may be an inorganic salt in conjunction with sodium acetate as a buffer salt, or an acetate salt may be used. Suitable metal salts mentioned are copper salts such as a copper sulphate or chloride, an iron salt such as ferrous or ferric sulphate or chloride, or a gold salt such as a gold chloride. In the examples, complex salts are formed from pyridine-4-carboxylic acid hydrazide and 4-aminosalicylic acid, and from pyridine-4-carboxylic acid hydrazide, 4-aminosalicylic acid and cupric sulphate in the presence of sodium acetate.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH744483X | 1952-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB744483A true GB744483A (en) | 1956-02-08 |
Family
ID=4533382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5247/53A Expired GB744483A (en) | 1952-02-25 | 1953-02-25 | Manufacture of 4-aminosalicylic acid salts of heterocyclic carboxylic hydrazides andof their complex copper, gold and iron salts |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB744483A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103539733A (en) * | 2013-10-23 | 2014-01-29 | 广州白云山制药股份有限公司广州白云山化学制药厂 | Preparation method of isoniazid para-aminosalicylate |
-
1953
- 1953-02-25 GB GB5247/53A patent/GB744483A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103539733A (en) * | 2013-10-23 | 2014-01-29 | 广州白云山制药股份有限公司广州白云山化学制药厂 | Preparation method of isoniazid para-aminosalicylate |
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