GB732415A - Process for the production of aroylated aminocarboxylic acids - Google Patents

Process for the production of aroylated aminocarboxylic acids

Info

Publication number
GB732415A
GB732415A GB16326/53A GB1632653A GB732415A GB 732415 A GB732415 A GB 732415A GB 16326/53 A GB16326/53 A GB 16326/53A GB 1632653 A GB1632653 A GB 1632653A GB 732415 A GB732415 A GB 732415A
Authority
GB
United Kingdom
Prior art keywords
aroylated
acids
alpha
omega amino
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB16326/53A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ruhrchemie AG
Original Assignee
Ruhrchemie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ruhrchemie AG filed Critical Ruhrchemie AG
Publication of GB732415A publication Critical patent/GB732415A/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Aroylated aminocarboxylic acids are produced by heating an aroylated alpha or omega amino-substituted aliphatic carboxylic acid amide with water or an aqueous ammonia solution at elevated pressure and at a temperature above 100 DEG C., and preferably in the range 160-180 DEG C. By this treatment, hydrolytic cleavage of the aroylated alpha or omega amino-substituted aliphatic carboxylic acid amides of the general formula R.CO.NH.(CH2)nCONH2 occurs, the cleavage being substantially exclusively between the CO and NH2 groups of the acid amide, with the formation of aroylated alpha or omega amino-carboxylic acids. In the formula, R represents the aryl group and the number n is preferably not more than 11. The preferred quantities of water or aqueous ammonia are such that the amide is in solution at the reaction temperature. The acids are obtained from the final solution by acidification with mineral acids. In examples hippuric acid and delta-benzamido-n-valeric acid are obtained from their corresponding amides.
GB16326/53A 1952-07-12 1953-06-12 Process for the production of aroylated aminocarboxylic acids Expired GB732415A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE732415X 1952-07-12

Publications (1)

Publication Number Publication Date
GB732415A true GB732415A (en) 1955-06-22

Family

ID=6639381

Family Applications (1)

Application Number Title Priority Date Filing Date
GB16326/53A Expired GB732415A (en) 1952-07-12 1953-06-12 Process for the production of aroylated aminocarboxylic acids

Country Status (1)

Country Link
GB (1) GB732415A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0046707A1 (en) * 1980-08-27 1982-03-03 Sanofi S.A. Derivatives of 4-aminobutyric acid and the medicines especially active on the central nervous system containing them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0046707A1 (en) * 1980-08-27 1982-03-03 Sanofi S.A. Derivatives of 4-aminobutyric acid and the medicines especially active on the central nervous system containing them

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