GB721414A - Improvements relating to the purification of impure aqueous solutions containing vitamin b and variants thereof - Google Patents

Improvements relating to the purification of impure aqueous solutions containing vitamin b and variants thereof

Info

Publication number
GB721414A
GB721414A GB2510652A GB2510652A GB721414A GB 721414 A GB721414 A GB 721414A GB 2510652 A GB2510652 A GB 2510652A GB 2510652 A GB2510652 A GB 2510652A GB 721414 A GB721414 A GB 721414A
Authority
GB
United Kingdom
Prior art keywords
zirconium
impure
variants
aqueous solution
solutions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2510652A
Inventor
Merton Cooke Lockhart
George Herman Michel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Priority to GB2510652A priority Critical patent/GB721414A/en
Publication of GB721414A publication Critical patent/GB721414A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Impure solutions containing Vitamin B12 and variants thereof, such as those obtained in the production of antibiotics by fermentation techniques, are purified by contacting the impure aqueous solution with a substantially water-insoluble zirconium compound, e.g. zirconium hydroxide, zirconium dioxide, carbonated zirconium hydrate or zirconium silicate, whereby the impurities are adsorbed thereon, and separating the purified aqueous solution containing the Vitamin B12 from the zirconium compound and the impurities adsorbed thereon. During the adsorption the pH of the impure aqueous solution is maintained in the range of 5 to 9 and the temperature in the range 0 DEG to 75 DEG C. In the examples a fermentation liquor produced by S. aureofaciens is pretreated by adsorption on charcoal, the eluate from which is treated with ammonium sulphate to produce a precipitate which is dissolved in aqueous ethyl alcohol and subsequently contacted with the zirconium compound.
GB2510652A 1952-10-07 1952-10-07 Improvements relating to the purification of impure aqueous solutions containing vitamin b and variants thereof Expired GB721414A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2510652A GB721414A (en) 1952-10-07 1952-10-07 Improvements relating to the purification of impure aqueous solutions containing vitamin b and variants thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2510652A GB721414A (en) 1952-10-07 1952-10-07 Improvements relating to the purification of impure aqueous solutions containing vitamin b and variants thereof

Publications (1)

Publication Number Publication Date
GB721414A true GB721414A (en) 1955-01-05

Family

ID=10222320

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2510652A Expired GB721414A (en) 1952-10-07 1952-10-07 Improvements relating to the purification of impure aqueous solutions containing vitamin b and variants thereof

Country Status (1)

Country Link
GB (1) GB721414A (en)

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