GB913042A - Improvements in or relating to purifying crystalline insulin - Google Patents
Improvements in or relating to purifying crystalline insulinInfo
- Publication number
- GB913042A GB913042A GB3575761A GB3575761A GB913042A GB 913042 A GB913042 A GB 913042A GB 3575761 A GB3575761 A GB 3575761A GB 3575761 A GB3575761 A GB 3575761A GB 913042 A GB913042 A GB 913042A
- Authority
- GB
- United Kingdom
- Prior art keywords
- relating
- impure
- crystalline insulin
- insulin
- crystallisate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Crystalline insulin contaminated with amorphous and microcrystalline impurities are purified by washing the impure crystallisate with an aqueous liquid the pH of which is held at from 3.8 to 4.3 (preferably from 4 to 4.3) with a weak acid or buffer mixture. The process may be applied to any impure insulin crystallisate obtained by standard methods but it is preferred to use crystallisates having an activity of at least 22 I.U. per mgm. Suitable wash liquids are dilute acetic acid, ammonium acetate/citrate, ammonium phosphate and sodium phosphate buffer solutions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL256653 | 1960-10-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB913042A true GB913042A (en) | 1962-12-12 |
Family
ID=19752616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3575761A Expired GB913042A (en) | 1960-10-07 | 1961-10-04 | Improvements in or relating to purifying crystalline insulin |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES270922A1 (en) |
| GB (1) | GB913042A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108929376A (en) * | 2017-05-23 | 2018-12-04 | 鲁南制药集团股份有限公司 | A kind of washing methods of insulin crystal or insulin analog crystal |
-
1961
- 1961-10-04 ES ES0270922A patent/ES270922A1/en not_active Expired
- 1961-10-04 GB GB3575761A patent/GB913042A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108929376A (en) * | 2017-05-23 | 2018-12-04 | 鲁南制药集团股份有限公司 | A kind of washing methods of insulin crystal or insulin analog crystal |
Also Published As
| Publication number | Publication date |
|---|---|
| ES270922A1 (en) | 1961-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1068817A (en) | Isolation of urokinase | |
| GB904478A (en) | Improved process of purifying plasminogen | |
| GB1484860A (en) | Manufacture of boric acid | |
| BE580663A (en) | Process for the preparation of concentrated aqueous solutions of polyacrylic acid amide. | |
| CH423747A (en) | Process for the continuous crystallization of adipic acid from its solutions | |
| FR1464229A (en) | Process for the purification of crude aqueous liquors containing malic acid | |
| GB913042A (en) | Improvements in or relating to purifying crystalline insulin | |
| GB1096707A (en) | Process for the purification of tertiary amines | |
| GB1103709A (en) | Purification of nicotinamide-adenine-dinucleotide | |
| GB786897A (en) | Purification of terephthalic acid | |
| GB950774A (en) | The production of cerium (iv) molybdate, tungstate and vanadate | |
| ES388664A1 (en) | Process for the recovery of ammonium sulphate from it aqueous solutions contaminated by organic substances | |
| FR1188782A (en) | Method of concentrating dilute aqueous hydrochloric acid solutions | |
| FR1228452A (en) | Process for the catalytic and selective decomposition of formic acid | |
| GB888659A (en) | Purification of adiponitrile | |
| GB947842A (en) | Improved process for the preparation of nitrocyclohexane | |
| FR1245613A (en) | Process for the high concentration of recovered saliferous acids, in particular dilute sulfuric acid containing sulphates | |
| GB902807A (en) | Improvements in or relating to the recovery of an antibiotic | |
| GB1118942A (en) | A process for obtaining purified glutamic acid | |
| Barta et al. | Treatment of waste waters from the manufacture of citric acid by sulphide fermentation | |
| JPS5249995A (en) | Method for purificating raw aqueous solution of zinc chloride system | |
| FR1282750A (en) | Nitric Acid Concentration Process | |
| GB990120A (en) | Process for the purification of dehydrocholic acid | |
| JPS5212127A (en) | Process for recovery of methylmethacrylate | |
| FR1304056A (en) | Process for the oxidation of cyclohexane to adipic acid |