GB708256A - New and improved derivatives of triazine and the manufacture thereof - Google Patents
New and improved derivatives of triazine and the manufacture thereofInfo
- Publication number
- GB708256A GB708256A GB2749750A GB2749750A GB708256A GB 708256 A GB708256 A GB 708256A GB 2749750 A GB2749750 A GB 2749750A GB 2749750 A GB2749750 A GB 2749750A GB 708256 A GB708256 A GB 708256A
- Authority
- GB
- United Kingdom
- Prior art keywords
- triazine
- amino
- guanidine
- pentahydrochloride
- refluxed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises 1 : 3 : 5-triazine derivatives of the general formula <FORM:0708256/IV (b)/1> (wherein R represents a monocyclic nitrogen-containing aromatic heterocyclic radical which may contain electron-attracting groups as substituents) and non-toxic acid addition salts thereof, and the preparation of the bases by reacting guanidine with a heterocyclic nitrile R-CN. The products are active as amoebicides. In examples (1) guanidine is refluxed with 3-cyanopyridine in alcohol to produce 2-amino-4 : 6-di-(31-pyridyl)-1 : 3 : 5-triazine, which may be converted into its hydrochloride by warming with concentrated aqueous hydrochloric acid, or into its pentahydrochloride by warming with concentrated hydrochloric acid and ethanol; reference is also made to the preparation of the dimethiodide by treating the base with methyl iodide in acetone; (2) guanidine is refluxed with 4-amino-2-methyl-5-cyanopyrimidine in alcohol to produce 2-amino-4 : 6-di-(41-amino - 21 - methylpyrimidyl - 51) - 1 : 3 : 5 - triazine, which yields a pentahydrochloride as in (1).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2749750A GB708256A (en) | 1950-11-10 | 1950-11-10 | New and improved derivatives of triazine and the manufacture thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2749750A GB708256A (en) | 1950-11-10 | 1950-11-10 | New and improved derivatives of triazine and the manufacture thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
GB708256A true GB708256A (en) | 1954-05-05 |
Family
ID=10260543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2749750A Expired GB708256A (en) | 1950-11-10 | 1950-11-10 | New and improved derivatives of triazine and the manufacture thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB708256A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1878733A1 (en) * | 2006-07-14 | 2008-01-16 | Novartis AG | Pyrimidine derivatives as ALK-5 inhibitors |
-
1950
- 1950-11-10 GB GB2749750A patent/GB708256A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1878733A1 (en) * | 2006-07-14 | 2008-01-16 | Novartis AG | Pyrimidine derivatives as ALK-5 inhibitors |
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