GB704516A - A blood anticoagulating agent and process for the manufacture thereof - Google Patents
A blood anticoagulating agent and process for the manufacture thereofInfo
- Publication number
- GB704516A GB704516A GB17341/52A GB1734152A GB704516A GB 704516 A GB704516 A GB 704516A GB 17341/52 A GB17341/52 A GB 17341/52A GB 1734152 A GB1734152 A GB 1734152A GB 704516 A GB704516 A GB 704516A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- chondroitin
- product
- sulphuric acid
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises a blood-anticoagulating agent comprising a polysulphuric acid ester of a hydrolytically degraded chondroitin-sulphuric acid, said ester having a sulphur content of between 11 and 16 per cent. and an intrinsic viscosity of from 0.05 and 0.10, and alkali salts of the same. They are prepared by hydrolyzing chondroitin-sulphuric acid until a product having an intrinsic viscosity of below 0.25 is obtained, and then converting to a polysulphuric acid, e.g. by treatment with chlorosulphonic acid, sulphur trioxide or oleum in the presence of an organic base such as pyridine, quinoline or a -picoline. The hydrolyzed material, before or after sulphation, may be subject to fractional precipitation, e.g. by means of acetone, methanol or ethanol. An example is given in which chondroitin-sulphuric acid is hydrolyzed with hydrochloric acid, esterified with chlorosulphonic acid in the presence of pyridine, and the product purified by precipitating it as the insoluble narcotine salt from which the product is finally recovered by treatment with aqueous sodium carbonate.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH704516X | 1951-07-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB704516A true GB704516A (en) | 1954-02-24 |
Family
ID=4530287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB17341/52A Expired GB704516A (en) | 1951-07-12 | 1952-07-09 | A blood anticoagulating agent and process for the manufacture thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB704516A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112500384A (en) * | 2020-12-07 | 2021-03-16 | 九江学院 | Synthetic method of flavonoid sulfate and application thereof under acidic condition |
-
1952
- 1952-07-09 GB GB17341/52A patent/GB704516A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112500384A (en) * | 2020-12-07 | 2021-03-16 | 九江学院 | Synthetic method of flavonoid sulfate and application thereof under acidic condition |
| CN112500384B (en) * | 2020-12-07 | 2023-10-17 | 九江学院 | Application of flavonoid sulfate in acidic condition |
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