GB746870A - Preparation of sulphated chitosan - Google Patents
Preparation of sulphated chitosanInfo
- Publication number
- GB746870A GB746870A GB28016/53A GB2801653A GB746870A GB 746870 A GB746870 A GB 746870A GB 28016/53 A GB28016/53 A GB 28016/53A GB 2801653 A GB2801653 A GB 2801653A GB 746870 A GB746870 A GB 746870A
- Authority
- GB
- United Kingdom
- Prior art keywords
- chitosan
- sulphated
- salt
- filtering
- reaction mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
The invention comprises (1) sulphated chitosan (preferably having a sulphur content of 5 to 23.9 per cent); (2) a salt of sulphated chitosan (preferably having a sulphur content of up to 20.6 per cent); and (3) the preparation of sulphated chitosan by treating chitosan with a sulphating agent, followed, if desired, by neutralizing the reaction mixture to give the corresponding salt. Sulphating agents are preferably fuming sulphuric acid, chlorosulphonic acid (e.g. in pyridine), or a mixture of sulphur dioxide and sulphur trioxide (preferably in a ratio between 1:1 and 30:1). The sulphur dioxide/trioxide treatment is preferably conducted at temperatures below 40 DEG C., in particular between 0 DEG and - 10 DEG C., and for a period of 10 to 24 hours. The sulphated chitosan or salts thereof may be isolated by filtering the reaction mixture or neutralized reaction mixture, washing the precipitate with an organic solvent, suspending the washed precipitate in water, filtering the suspension to remove unreacted chitosan, dialyzing the filtrate, and lyophilizing the dialyzed product. Salts of sulphated chitosan may also be prepared by subsequent conversion of the barium salt, or by treating the suspension of chitosan sulphate in water with, for example, an alkali, filtering, dialyzing, and precipitating the salt with acetone or alcohol, or by evaporating the dialyzed filtrate to dryness. The preparation of the sodium, potassium, calcium, pyridinium and quinolium salts of sulphated chitosan is described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US746870XA | 1952-10-15 | 1952-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB746870A true GB746870A (en) | 1956-03-21 |
Family
ID=22121045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28016/53A Expired GB746870A (en) | 1952-10-15 | 1953-10-12 | Preparation of sulphated chitosan |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB746870A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0194497A2 (en) * | 1985-03-14 | 1986-09-17 | Etablissement Texcontor | Chitosan derivatives in the form of coordinated complexes with ferrous ions |
| FR2744930A1 (en) * | 1996-02-15 | 1997-08-22 | Commissariat Energie Atomique | PROCESS FOR SEPARATING AT LEAST ONE METAL PRESENT IN A SOLUTION BY FIXING ON A CHITOSAN |
-
1953
- 1953-10-12 GB GB28016/53A patent/GB746870A/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0194497A2 (en) * | 1985-03-14 | 1986-09-17 | Etablissement Texcontor | Chitosan derivatives in the form of coordinated complexes with ferrous ions |
| EP0194497A3 (en) * | 1985-03-14 | 1988-03-16 | Etablissement Texcontor | Chitosan derivatives in the form of coordinated complexes with ferrous ions |
| US4810695A (en) * | 1985-03-14 | 1989-03-07 | Establissement Texcontor | Chitosan derivatives in the form of coordinated complexes with ferrous ions |
| FR2744930A1 (en) * | 1996-02-15 | 1997-08-22 | Commissariat Energie Atomique | PROCESS FOR SEPARATING AT LEAST ONE METAL PRESENT IN A SOLUTION BY FIXING ON A CHITOSAN |
| US5932107A (en) * | 1996-02-15 | 1999-08-03 | Commissariat A L'energie Atomique | Method of separating at least one metal present in a solution by fixation onto a chitosane |
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