GB685331A - Improvements in cyclopentanophenanthrene derivatives and process for producing the same - Google Patents

Improvements in cyclopentanophenanthrene derivatives and process for producing the same

Info

Publication number
GB685331A
GB685331A GB21136/50A GB2113650A GB685331A GB 685331 A GB685331 A GB 685331A GB 21136/50 A GB21136/50 A GB 21136/50A GB 2113650 A GB2113650 A GB 2113650A GB 685331 A GB685331 A GB 685331A
Authority
GB
United Kingdom
Prior art keywords
allopregnane
dione
producing
same
collidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB21136/50A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex SA
Original Assignee
Syntex SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex SA filed Critical Syntex SA
Publication of GB685331A publication Critical patent/GB685331A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Allopregnane - 17a - ol - 3,20 - dione is produced by treating allopregnane-3b , 17a -diol-20-one with an amide of the formula <FORM:0685331/IV (b)/1> where R is an aromatic or aliphatic radical and X is a bromine or chlorine atom. D 1,2-allopregnene-17a -ol-3,20-dione is obtained from allopregnane-17a -ol-3,20-dione by treating with bromine to produce 2-bromo-allopregnane-17a -ol-3,20-dione and dehydrobrominating. The first step of the reaction may be effected with bromacetamide, bromotoluene-sulphonamide, bromophthalimide, bromosuccimide or chlorosuccimide in the presence of pyridine, collidine, lutidine or diethyl aniline. Dehydrobromination can be effected with collidine, pyridine, lutidine or diethyl aniline.
GB21136/50A 1949-09-19 1950-08-25 Improvements in cyclopentanophenanthrene derivatives and process for producing the same Expired GB685331A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US685331XA 1949-09-19 1949-09-19

Publications (1)

Publication Number Publication Date
GB685331A true GB685331A (en) 1952-12-31

Family

ID=22083169

Family Applications (1)

Application Number Title Priority Date Filing Date
GB21136/50A Expired GB685331A (en) 1949-09-19 1950-08-25 Improvements in cyclopentanophenanthrene derivatives and process for producing the same

Country Status (1)

Country Link
GB (1) GB685331A (en)

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