FR2143583A1 - 17-substituted pregna-4,9(10)-dienes - with antiandrogenic antigonadotrophic and antioestrogenic acivity - Google Patents

17-substituted pregna-4,9(10)-dienes - with antiandrogenic antigonadotrophic and antioestrogenic acivity

Info

Publication number
FR2143583A1
FR2143583A1 FR7123886A FR7123886A FR2143583A1 FR 2143583 A1 FR2143583 A1 FR 2143583A1 FR 7123886 A FR7123886 A FR 7123886A FR 7123886 A FR7123886 A FR 7123886A FR 2143583 A1 FR2143583 A1 FR 2143583A1
Authority
FR
France
Prior art keywords
cpds
antigonadotrophic
antioestrogenic
acivity
antiandrogenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7123886A
Other languages
French (fr)
Other versions
FR2143583B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7123886A priority Critical patent/FR2143583A1/en
Publication of FR2143583A1 publication Critical patent/FR2143583A1/en
Application granted granted Critical
Publication of FR2143583B1 publication Critical patent/FR2143583B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

Title cpds of formula: (where R is 2-4C alkyl, R1 is 1-3C alkyl) are useful for treating prostatic adenoma, acne and hirsutism, the adult dose being 0.2-20 mg/day. They may be prepd by subjecting cpds (III) of formula: to a Birch reaction to give cpds (IV) of formula: which are then hydrolysed to give cpds (V; Z is OH of formula: H which are oxidised to cpds (V; Z is O) which are finally brominated and then dehydrobrominated.
FR7123886A 1971-06-30 1971-06-30 17-substituted pregna-4,9(10)-dienes - with antiandrogenic antigonadotrophic and antioestrogenic acivity Granted FR2143583A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7123886A FR2143583A1 (en) 1971-06-30 1971-06-30 17-substituted pregna-4,9(10)-dienes - with antiandrogenic antigonadotrophic and antioestrogenic acivity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7123886A FR2143583A1 (en) 1971-06-30 1971-06-30 17-substituted pregna-4,9(10)-dienes - with antiandrogenic antigonadotrophic and antioestrogenic acivity

Publications (2)

Publication Number Publication Date
FR2143583A1 true FR2143583A1 (en) 1973-02-09
FR2143583B1 FR2143583B1 (en) 1974-08-23

Family

ID=9079594

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7123886A Granted FR2143583A1 (en) 1971-06-30 1971-06-30 17-substituted pregna-4,9(10)-dienes - with antiandrogenic antigonadotrophic and antioestrogenic acivity

Country Status (1)

Country Link
FR (1) FR2143583A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0001308A1 (en) * 1977-09-26 1979-04-04 Akzo N.V. Novel delta-4,9-pregnane derivatives, their use as progestational and/or ovulation-inhibiting agents and process for their preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0001308A1 (en) * 1977-09-26 1979-04-04 Akzo N.V. Novel delta-4,9-pregnane derivatives, their use as progestational and/or ovulation-inhibiting agents and process for their preparation

Also Published As

Publication number Publication date
FR2143583B1 (en) 1974-08-23

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Legal Events

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