GB679202A - Improvements in or relating to the production of 5-nitrofuran derivatives - Google Patents
Improvements in or relating to the production of 5-nitrofuran derivativesInfo
- Publication number
- GB679202A GB679202A GB27962/49A GB2796249A GB679202A GB 679202 A GB679202 A GB 679202A GB 27962/49 A GB27962/49 A GB 27962/49A GB 2796249 A GB2796249 A GB 2796249A GB 679202 A GB679202 A GB 679202A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nitration
- methyl
- nitric acid
- specific gravity
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Abstract
In a process of nitrating furan compounds by means of nitric acid having a specific gravity not less than 1.42 and acetic anhydride to give an intermediate which is converted to the 5-nitrofuran compound, the process is characterised by the feature that the nitration mixture without isolation is diluted with water, preferably with 1-3 volumes of ice water, and the pH is adjusted to within the range 1.79-4.66, preferably to 3.7, by the addition of a base, preferably trisodium phosphate, and the temperature is maintained at 25 DEG to 60 DEG C., preferably about 55 DEG C. It is preferred that the nitration mixture is prepared by use of concentrated nitric acid, e.g. specific gravity 1.42, and at a temperature of between 0 DEG and 50 DEG C. In examples, there is described the nitration under the above conditions of (1) and (2) pure furfural (yielding 5-nitrofurfural diacetate), (3) furfuryl propionate, and (4) methyl furoate. Samples have been filed under Sect. 2 (5) of the products obtained by nitration under the conditions of the invention of (1) methyl-2-furyl ketone, (2) 2-furfuryl-methyl ether and (3) 2-methylfuran.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB27962/49A GB679202A (en) | 1949-11-01 | 1949-11-01 | Improvements in or relating to the production of 5-nitrofuran derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB27962/49A GB679202A (en) | 1949-11-01 | 1949-11-01 | Improvements in or relating to the production of 5-nitrofuran derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB679202A true GB679202A (en) | 1952-09-17 |
Family
ID=10268063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27962/49A Expired GB679202A (en) | 1949-11-01 | 1949-11-01 | Improvements in or relating to the production of 5-nitrofuran derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB679202A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1154487B (en) * | 1959-02-20 | 1963-09-19 | Norwich Pharma Co | Process for the preparation of 5-nitrofuryl- (2) -methylketone |
-
1949
- 1949-11-01 GB GB27962/49A patent/GB679202A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1154487B (en) * | 1959-02-20 | 1963-09-19 | Norwich Pharma Co | Process for the preparation of 5-nitrofuryl- (2) -methylketone |
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