GB669782A - Improved pellets for pharmaceutical use - Google Patents

Abstract

669,782. Pharmaceutical pellets. STRONG, COBB & CO., Inc. Sept. 27, 1949 [Oct. 30, 1948], No. 24802/49. Class 81 (i). A pharmaceutical pellet has an inner therapeutic portion 10, an outer therapeutic portion 12 and a spacing layer 11 therebetween, the nature of said layer being such that the active therapeutic agents of said inner and outer portions are separately released in the body of the patient under pH conditions which are different and favourable thereto. The therapeutic layers may be coated with a protective transition layer of e.g. gelatin, varnish, lacquer or wax (as appropriate to desired pH conditions) and the finished pellet with a final layer 13 of e.g. sugar syrup, as such, or in combination with fillers such as calcium carbonate, talc and calcium pyrophosphate, colours and wax. The spacing layer may be of hard fats, waxes, fattyacids, keratin, salol, shellac, sandarac, lacquers or colloidin. An example is given of a pellet containing pancreatin, bile (including bile salts and acids e.g. sodium taurocholate), an antacid e.g. calcium carbonate, magnesium hydroxide, aluminium hydroxide or magnesium trisilicate and a binder and incipient e.g. acacia, gelatin, tragacanth, starch paste or glucose forming a central therapeutic core, which is coated with a transition layer of gelatin, a spacing layer, a therapeutic layer of pepsin and a weak organic acid such as tartaric or citric acid, if desired with the further addition of rennin, followed by a transition layer and a finishing layer. The pancreatin may be replaced wholly or in part by amilopsin, trypsin or steapsin. Specifications 285,091, [Class 81 (i)], and 638,606 are referred to.