GB1139869A - Improvements in or relating to tablets - Google Patents

Improvements in or relating to tablets

Info

Publication number
GB1139869A
GB1139869A GB70766A GB70766A GB1139869A GB 1139869 A GB1139869 A GB 1139869A GB 70766 A GB70766 A GB 70766A GB 70766 A GB70766 A GB 70766A GB 1139869 A GB1139869 A GB 1139869A
Authority
GB
United Kingdom
Prior art keywords
water
drug
tablet
tablets
layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB70766A
Inventor
David Frederick Cleaver
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MOORE MEDICINAL PRODUCTS Ltd
Original Assignee
MOORE MEDICINAL PRODUCTS Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MOORE MEDICINAL PRODUCTS Ltd filed Critical MOORE MEDICINAL PRODUCTS Ltd
Priority to GB70766A priority Critical patent/GB1139869A/en
Publication of GB1139869A publication Critical patent/GB1139869A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2873—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)

Abstract

1,139,869. Multilayer tablets. MOORE MEDICINAL PRODUCTS Ltd. 6 Jan., 1967 [6 Jan., 1966], No. 707/66. Heading A5B. A multilayer tablet comprises one layer formed from a mixture of a water-soluble drug and a pharmaceutically acceptable waterabsorbent substance which forms one or more stable hydrates (e.g. citric acid or its Na or K salt, or the Na or K salt of tartaric or phosphoric acid), but which is'-present in a fully or partially dehydrated form, the other layer or layers present not being water-absorbent. The other layer, or one of the other layers present may contain a water-insoluble drug. The acids or salts may initially be admixed with the drug in dehydrated form or they may be dehydrated by the action of heat during the preparation of the admixture for the tabletting operation. The example relates to a tablet with a core consisting of sucrose, methylephedrine hydrochloride, theophylline hydrate and magnesium stearate coated with a composition of gelatin, sucrose, talc, isoprenaline sulphate, antioxidants, citric acid and colouring agents. The tablets of the invention ensure that a water-soluble drug is retained in the desired location in the tablet. Enteric coatings may be used where desired.
GB70766A 1966-01-06 1966-01-06 Improvements in or relating to tablets Expired GB1139869A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB70766A GB1139869A (en) 1966-01-06 1966-01-06 Improvements in or relating to tablets

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB70766A GB1139869A (en) 1966-01-06 1966-01-06 Improvements in or relating to tablets

Publications (1)

Publication Number Publication Date
GB1139869A true GB1139869A (en) 1969-01-15

Family

ID=9709143

Family Applications (1)

Application Number Title Priority Date Filing Date
GB70766A Expired GB1139869A (en) 1966-01-06 1966-01-06 Improvements in or relating to tablets

Country Status (1)

Country Link
GB (1) GB1139869A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0013131A2 (en) * 1978-12-27 1980-07-09 Mundipharma A.G. Pharmaceutical composition in solid dosage form, and process for its production
FR2470599A1 (en) * 1979-12-07 1981-06-12 Panoz Donald IMPROVEMENTS IN PROCESSES FOR THE PREPARATION OF GALENIC SHAPES WITH DELAYED ACTION AND PROGRAMMED RELEASE AND GALENIC FORMS OF MEDICAMENTS THUS OBTAINED
EP0111144A1 (en) * 1982-11-01 1984-06-20 Merrell Dow Pharmaceuticals Inc. Sustained release solid dosage forms having non-uniform distribution of active ingredient
WO2004050067A1 (en) * 2002-11-29 2004-06-17 Cipla Limited PHARMACEUTICAL FORMULATIONS COMPRISING β-2 ADRENORECEPTOR AGONISTS AND XANTHINES

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0013131A2 (en) * 1978-12-27 1980-07-09 Mundipharma A.G. Pharmaceutical composition in solid dosage form, and process for its production
EP0013131A3 (en) * 1978-12-27 1981-01-07 Mundipharma A.G. Pharmaceutical composition in solid dosage form, and process for its production
FR2470599A1 (en) * 1979-12-07 1981-06-12 Panoz Donald IMPROVEMENTS IN PROCESSES FOR THE PREPARATION OF GALENIC SHAPES WITH DELAYED ACTION AND PROGRAMMED RELEASE AND GALENIC FORMS OF MEDICAMENTS THUS OBTAINED
WO1981001652A1 (en) * 1979-12-07 1981-06-25 D Panoz Improvements to methods for preparing galenical preparation with delayed action and programmed release and galenical preparations for drugs obtained thereby
US5051262A (en) * 1979-12-07 1991-09-24 Elan Corp., P.L.C. Processes for the preparation of delayed action and programmed release pharmaceutical forms and medicaments obtained thereby
EP0111144A1 (en) * 1982-11-01 1984-06-20 Merrell Dow Pharmaceuticals Inc. Sustained release solid dosage forms having non-uniform distribution of active ingredient
WO2004050067A1 (en) * 2002-11-29 2004-06-17 Cipla Limited PHARMACEUTICAL FORMULATIONS COMPRISING β-2 ADRENORECEPTOR AGONISTS AND XANTHINES
GB2410187A (en) * 2002-11-29 2005-07-27 Cipla Ltd Pharmaceutical formulations comprising ß-2 adrenoreceptor agonists and xanthines
GB2410187B (en) * 2002-11-29 2007-06-20 Cipla Ltd Pharmaceutical formulations comprising ß-2 adrenoreceptor agonists and xanthines

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