IE36335L - Sustained/immediate release veterinary layered bolus - Google Patents
Sustained/immediate release veterinary layered bolusInfo
- Publication number
- IE36335L IE36335L IE720562A IE56272A IE36335L IE 36335 L IE36335 L IE 36335L IE 720562 A IE720562 A IE 720562A IE 56272 A IE56272 A IE 56272A IE 36335 L IE36335 L IE 36335L
- Authority
- IE
- Ireland
- Prior art keywords
- bolus
- sustained release
- medicament
- release layer
- immediate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0068—Rumen, e.g. rumen bolus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Abstract
1330829 Immediate and sustained release layered bolus SMITH KLINE & FRENCH LABORATORIES 18 May 1972 [18 May 1971] 23426/72 Heading A5B A sustained release veterinary layered bolus comprising an immediate release layer and, contiguous therewith, a sustained release layer, the immediate release layer having a disintegration time in the rumen of less than 30 minutes and comprising sufficient of a medicament rapidly to provide a therapeutic level of the medicament in the blood of the ruminant animal to which the bolus is administered and the sustained release layer comprising a filler matrix of such a density that the bolus will lodge in the rumenoreticular sac of the ruminant animal and sufficient of the medicament that, at the rate of disintegration of the sustained release layer, a therapeutic level of the medicament is maintained in the blood of the ruminant animal to which the bolus is administered for at least 72 hours from the time of dosage, may be prepared by preparing separate immediate and sustained release granulations containing a medicament and a filler which at least in the sustained release granulation is of such a density that the bolus will lodge in the rumeno-reticular sac of the ruminant animal, placing the granulations in separate hoppers and selectively compressing the granulations into a layered bolus. The filler matrix may be iron powder, calcium sulphate dihydrate; Portland cement, plaster of Paris and/ or magnesium oxyiodide cement. The sustained release effect may be accomplished by employing a lubricant such as magnesium stearate, sodium stearate, calcium stearate, powdered stearic acid, talc, paraffin, cocoa butter, graphite and/or lycopodium. The medicament may be a sulphonamide derivative such as sulphamethazine or sulphathiazine; a tranquilizer such as chlorpromazine; an antibiotic such as chloramphenicol, tetracycline or penicillin; an anthelmintic such as piperazine phosphate, an anti-bloat agent such as organopolysilpxane; a hormone growth supplement such as stilbesterol, a vitamin or antibacterial such as furazolidone.
[GB1330829A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14449971A | 1971-05-18 | 1971-05-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36335L true IE36335L (en) | 1972-11-18 |
| IE36335B1 IE36335B1 (en) | 1976-10-13 |
Family
ID=22508878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE562/72A IE36335B1 (en) | 1971-05-18 | 1972-04-27 | Layered bolus for animal husbandry providing for immediate and sustained release of medicament |
Country Status (10)
| Country | Link |
|---|---|
| AU (1) | AU470023B2 (en) |
| BE (1) | BE783321A (en) |
| CA (1) | CA997677A (en) |
| DE (1) | DE2224390A1 (en) |
| ES (1) | ES402545A1 (en) |
| FR (1) | FR2138011B1 (en) |
| GB (1) | GB1330829A (en) |
| IE (1) | IE36335B1 (en) |
| NL (1) | NL7206328A (en) |
| ZA (1) | ZA722664B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4137300A (en) * | 1976-08-20 | 1979-01-30 | Ciba-Geigy Corporation | Sustained action dosage forms |
| GB2093348B (en) * | 1981-02-23 | 1984-09-12 | Leo Pharm Prod Ltd | Pharmaceutical composition for implantation |
| NZ204861A (en) * | 1982-07-20 | 1986-10-08 | Nat Res Dev | Sustained release device:trace element incorporated in cement |
| FR2560768A1 (en) * | 1984-03-07 | 1985-09-13 | Crb Virbac Sa | PROGRAMMED RELEASE DEVICE |
| NZ234227A (en) * | 1989-06-30 | 1991-08-27 | Smithkline Beecham Corp | Delayed release dosage form |
| US5190760A (en) * | 1989-07-08 | 1993-03-02 | Coopers Animal Health Limited | Solid pharmaceutical composition |
| GB8915716D0 (en) * | 1989-07-08 | 1989-08-31 | Coopers Animal Health | Pharmaceutical compositions |
| MXPA02004413A (en) * | 1999-11-02 | 2002-09-02 | Depomed Inc | Pharmacological inducement of the fed mode for enhanced drug administration to the stomach. |
| MXPA02007254A (en) | 2000-02-04 | 2002-12-09 | Depomed Inc | Shell and core dosage form approaching zero order drug release. |
| CA2409552A1 (en) | 2001-10-25 | 2003-04-25 | Depomed, Inc. | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
| US6723340B2 (en) | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
| US6682759B2 (en) | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
| US20050013863A1 (en) | 2003-07-18 | 2005-01-20 | Depomed, Inc., A Corporation Of The State Of California | Dual drug dosage forms with improved separation of drugs |
| CN104523636B (en) * | 2014-12-25 | 2017-07-18 | 昆明振华制药厂有限公司 | A kind of furazolidone sustained release tablets and preparation method thereof |
| AU2021396978A1 (en) | 2020-12-08 | 2023-02-23 | Ruminant Biotech Corp Limited | Improvements to devices and methods for delivery of substances to animals |
-
1972
- 1972-04-19 ZA ZA722664A patent/ZA722664B/en unknown
- 1972-04-27 IE IE562/72A patent/IE36335B1/en unknown
- 1972-05-09 ES ES402545A patent/ES402545A1/en not_active Expired
- 1972-05-10 NL NL7206328A patent/NL7206328A/xx not_active Application Discontinuation
- 1972-05-10 BE BE783321A patent/BE783321A/en not_active IP Right Cessation
- 1972-05-15 AU AU42309/72A patent/AU470023B2/en not_active Expired
- 1972-05-17 CA CA142,402A patent/CA997677A/en not_active Expired
- 1972-05-17 FR FR727217600A patent/FR2138011B1/fr not_active Expired
- 1972-05-18 GB GB2342672A patent/GB1330829A/en not_active Expired
- 1972-05-18 DE DE2224390A patent/DE2224390A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IE36335B1 (en) | 1976-10-13 |
| ZA722664B (en) | 1973-01-31 |
| CA997677A (en) | 1976-09-28 |
| AU470023B2 (en) | 1976-03-04 |
| NL7206328A (en) | 1972-11-21 |
| BE783321A (en) | 1972-11-10 |
| AU4230972A (en) | 1973-11-22 |
| DE2224390A1 (en) | 1973-12-13 |
| GB1330829A (en) | 1973-09-19 |
| ES402545A1 (en) | 1975-04-01 |
| FR2138011B1 (en) | 1973-07-13 |
| FR2138011A1 (en) | 1972-12-29 |
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