GB667113A - Improvements in or relating to processes of preparing 8-haloxanthine salts of antihistaminic amines - Google Patents

Improvements in or relating to processes of preparing 8-haloxanthine salts of antihistaminic amines

Info

Publication number
GB667113A
GB667113A GB9288/49A GB928849A GB667113A GB 667113 A GB667113 A GB 667113A GB 9288/49 A GB9288/49 A GB 9288/49A GB 928849 A GB928849 A GB 928849A GB 667113 A GB667113 A GB 667113A
Authority
GB
United Kingdom
Prior art keywords
radicals
chloroxanthine
amino
amino radicals
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB9288/49A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Priority to GB9288/49A priority Critical patent/GB667113A/en
Publication of GB667113A publication Critical patent/GB667113A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

An 8-haloxanthine salt of an aminoalkyl diarylalkyl ether of formula <FORM:0667113/IV (b)/1> where Ar and Ar1 are lower aryl, R is lower alkyl or hydrogen, Alk is lower alkylene radical having from 1-4 carbon atoms and B is an aliphatic type organic amino radical, is prepared by treating the above compound with an 8-haloxanthine which contains a hydrogen atom in position 7. Examples of radicals denoted by Ar and Ar1 are phenyl, tolyl, chlorophenyl, bromophenyl, iodophenyl, methoxyphenyl, ethoxyphenyl, and xylyl. Examples of the radical B are mono- and di-(lower alkyl) amino radicals wherein the lower alkyl radicals may be the same or different and the corresponding mono- or di-hydroxyalkyl) amino radicals. B may also represent cyclic amino radicals and heterocyclic amino radicals which are aliphatic in character. It includes amino group such as cyclohexylamino, cyclopentylamino, morpholino, piperidino, pyrrolidino, thiamorpholino, and alkyl derivatives of such amino radicals. Acidic xanthines mentioned include 8 - chlorotheophylline, 8 - bromotheophylline, 8 - chloroxanthine, 3 - methyl - 8-chloroxanthine, 8 - bromoxanthine, 3 - methyl-8 - chloroxanthine, 1 : 3 - diethyl - 8 - bromoxanthine, 1 : 3 - diethyl - 8 - chloroxanthine, 8 - iodotheophylline, 8 - iodo - 1 : 3 - dimethylxanthine. In examples various combinations of the above components are described. b -cyclohexylaminoethyl benzohydryl ether is made by refluxing b -chloroethyl benzohydryl ether and cyclohexylamine in butanone in the presence of potassium idoide.
GB9288/49A 1949-04-05 1949-04-05 Improvements in or relating to processes of preparing 8-haloxanthine salts of antihistaminic amines Expired GB667113A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9288/49A GB667113A (en) 1949-04-05 1949-04-05 Improvements in or relating to processes of preparing 8-haloxanthine salts of antihistaminic amines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9288/49A GB667113A (en) 1949-04-05 1949-04-05 Improvements in or relating to processes of preparing 8-haloxanthine salts of antihistaminic amines

Publications (1)

Publication Number Publication Date
GB667113A true GB667113A (en) 1952-02-27

Family

ID=9869093

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9288/49A Expired GB667113A (en) 1949-04-05 1949-04-05 Improvements in or relating to processes of preparing 8-haloxanthine salts of antihistaminic amines

Country Status (1)

Country Link
GB (1) GB667113A (en)

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