GB653803A - Synthesis of the amino acid, d;1-methionine - Google Patents

Synthesis of the amino acid, d;1-methionine

Info

Publication number
GB653803A
GB653803A GB29483/47A GB2948347A GB653803A GB 653803 A GB653803 A GB 653803A GB 29483/47 A GB29483/47 A GB 29483/47A GB 2948347 A GB2948347 A GB 2948347A GB 653803 A GB653803 A GB 653803A
Authority
GB
United Kingdom
Prior art keywords
methionine
treating
give
bisulphite
reactions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB29483/47A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB653803A publication Critical patent/GB653803A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

dl-Methionine is prepared by treating b -methylmercaptopropionaldehyde with an alkali metal bisulphite to give the bisulphite addition product, treating this with an inorganic cyanide to give b -methylmercaptopropionaldehyde cyanohydrin, treating this with ammonium bicarbonate, carbonate or carbamate to give methionine hydantoin, and hydrolysing this to dl-methionine. The bisulphite may be sodium or potassium, and the inorganic cyanide may be the alkali metal, alkaline earth metal, e.g. magnesium, or ammonium salt. The reactions may be performed in an aqueous medium, or in an aqueous water-soluble organic solvent such as a lower aliphatic alcohol, e.g. methanol. In the examples, dl-methionine is prepared by the above sequence of reactions, the hydantoin being hydrolysed with aqueous sodium hydroxide at 100 DEG C.
GB29483/47A 1946-12-20 1947-11-05 Synthesis of the amino acid, d;1-methionine Expired GB653803A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US653803XA 1946-12-20 1946-12-20

Publications (1)

Publication Number Publication Date
GB653803A true GB653803A (en) 1951-05-23

Family

ID=22062319

Family Applications (1)

Application Number Title Priority Date Filing Date
GB29483/47A Expired GB653803A (en) 1946-12-20 1947-11-05 Synthesis of the amino acid, d;1-methionine

Country Status (1)

Country Link
GB (1) GB653803A (en)

Similar Documents

Publication Publication Date Title
GB653803A (en) Synthesis of the amino acid, d;1-methionine
GB934292A (en) Process for the preparation of heterocyclic compounds
GB945578A (en) Mono adducts of dialdehydes
GB630139A (en) Improvements in the production of d,l -methionine
GB1352781A (en) Process for the preparation of dl-methionine
GB566006A (en) Improvements in or relating to the production of alpha-chloro, beta-hydroxynitriles
GB670774A (en) Preparation of dl-methionine
GB730923A (en) Process for the preparation of a new aldehyde derivative
GB800777A (en) A novel pyrimidine derivative and a process for the manufacture thereof
JPS5612327A (en) Manufacture of 3*33dimethylarylalcohol
GB1024657A (en)
GB633459A (en) A process for the manufacture of n-(p-arsenosobenzyl)-glycine-amide and salts thereof
GB786806A (en) Improvements in the preparation of dichloroacet-4-hydroxy-n-methylanilide
GB1240207A (en) PROCESS FOR THE PREPARATION OF beta-LACTAMS
GB348134A (en) Improvements in the manufacture and production of alkylene cyanhydrins
GB568850A (en) Guanidine derivatives
GB451268A (en) Manufacture of hydantoins
GB642457A (en) Improvements in or relating to the preparation of organo antimony derivatives
GB855193A (en) Improvements in or relating to the manufacture of derivatives of nitrofurfuraldehyde
GB716137A (en) Preparation of methionine hydantoin
GB1159326A (en) Method of Hydrolysing Aminonitriles
GB712207A (en) New sulphonamide compounds and process of preparing the same
GB562216A (en) Improvements in and relating to the manufacture of water soluble derivatives of 4:4-diaminodiphenylsulphone
GB591816A (en) Process for the production of nitro-olefines
GB593110A (en) Manufacture of derivative of p-toluenesulphonamide