GB650187A - Production of antibiotics - Google Patents

Production of antibiotics

Info

Publication number
GB650187A
GB650187A GB14441/48A GB1444148A GB650187A GB 650187 A GB650187 A GB 650187A GB 14441/48 A GB14441/48 A GB 14441/48A GB 1444148 A GB1444148 A GB 1444148A GB 650187 A GB650187 A GB 650187A
Authority
GB
United Kingdom
Prior art keywords
per cent
distillers
solubles
streptomycin
medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB14441/48A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB650187A publication Critical patent/GB650187A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

Streptomycin is produced by propagating Streptomyces griseus under submerged aerated conditions in an aqueous nutrient medium containing soya bean meal, distillers' solubles and an assimilable carbohydrate, with or without other complex nitrogenous organic materials. The soyabean meal may be present to the extent of 1-5 per cent (preferably 1-2 per cent) and the distillers' solubles 0.1-2 per cent (preferably 1.0-1.5 per cent), expressed as grams per 100 millilitres. The carbohydrate, e.g. dextrose or hydrol (by-product from hydrolysis of starch) may be present in amounts up to 4 per cent (preferably 0.75-2 per cent). The medium may also contain sodium chloride up to 3 per cent, e.g. 0.1-1.0 per cent. The medium is sterilized, inoculated with S. griseus (spores or vegetative inoculum) and fermented. The streptomycin is recovered by adsorption from the culture broth with activated charcoal and elution, e.g. with low-normality alcoholic hydrochloric acid.
GB14441/48A 1947-06-20 1948-05-28 Production of antibiotics Expired GB650187A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US650187XA 1947-06-20 1947-06-20

Publications (1)

Publication Number Publication Date
GB650187A true GB650187A (en) 1951-02-14

Family

ID=22059797

Family Applications (1)

Application Number Title Priority Date Filing Date
GB14441/48A Expired GB650187A (en) 1947-06-20 1948-05-28 Production of antibiotics

Country Status (1)

Country Link
GB (1) GB650187A (en)

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