SE7612293L - ANTIBIOTIC - Google Patents

ANTIBIOTIC

Info

Publication number
SE7612293L
SE7612293L SE7612293A SE7612293A SE7612293L SE 7612293 L SE7612293 L SE 7612293L SE 7612293 A SE7612293 A SE 7612293A SE 7612293 A SE7612293 A SE 7612293A SE 7612293 L SE7612293 L SE 7612293L
Authority
SE
Sweden
Prior art keywords
antibiotic
inorganic
shows
nrrl
pathogens
Prior art date
Application number
SE7612293A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE426845B (en
Inventor
P J Cassidy
R T Goegelman
E O Stapley
S Hermandez
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SE7612293L publication Critical patent/SE7612293L/en
Publication of SE426845B publication Critical patent/SE426845B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Abstract

A strain of Streptomyces flavogriseus, preferably NRRL 8139 or 8140, is cultivated under submerged aerobic conditions in an aqueous nutrient medium which contains assimilable C and N sources and inorganic salts, and the produced antibiotic is isolated. The antibiotic, also in the form of non-toxic, pharmaceutically acceptable salts which can be obtained by reaction with inorganic or organic bases, shows remarkable antibiotic properties and is active against a wide range of pathogens as well as against resistant strains of particular microorganisms. The antibiotic shows in vivo activity against Gram-negative and -positive organisms and is suitable for use in human and veterinary medicine and as an antibacterial agent for commercial and industrial purposes.
SE7612293A 1975-11-21 1976-11-04 PREPARATION OF NEW ISOMERA ANTIBIOTICS NAMED 890A, AND 890A3 WITH STATED FORM BY CULTIVATION OF STREPTOMYCES FLAVOGRISEUS NRRL 8139 OR 8140 SE426845B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63430075A 1975-11-21 1975-11-21

Publications (2)

Publication Number Publication Date
SE7612293L true SE7612293L (en) 1977-05-22
SE426845B SE426845B (en) 1983-02-14

Family

ID=24543234

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7612293A SE426845B (en) 1975-11-21 1976-11-04 PREPARATION OF NEW ISOMERA ANTIBIOTICS NAMED 890A, AND 890A3 WITH STATED FORM BY CULTIVATION OF STREPTOMYCES FLAVOGRISEUS NRRL 8139 OR 8140

Country Status (8)

Country Link
JP (1) JPS5265293A (en)
CH (1) CH625553A5 (en)
DE (1) DE2652677C2 (en)
DK (1) DK143712C (en)
FR (1) FR2332017A1 (en)
GB (1) GB1561109A (en)
NL (1) NL7612933A (en)
SE (1) SE426845B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK145504C (en) * 1976-04-28 1983-04-25 Merck & Co Inc PROCEDURE FOR THE PREPARATION OF ANTIBIOTIC SUBSTANCE 890A2OG / OR ANTIBIOTIC SUBSTANCE 890A5 AND PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
NL7712093A (en) * 1976-11-19 1978-05-23 Merck & Co Inc PROCESS FOR PREPARING ISOMERIC THIENAMYCINS.
DE2808563A1 (en) * 1977-03-05 1978-09-07 Beecham Group Ltd DERIVATIVES OF 3-THIO-6- (1-HYDROXYAETHYL) -7-OXO-1-AZA-BICYCLO SQUARE CLAMP ON 3.2.0 SQUARE CLAMP FOR HEPT-2-EN-2-CARBONIC ACID, PROCESS FOR THEIR PRODUCTION AND CONTAINING THESE COMPOUNDS DRUG
US4162323A (en) * 1977-04-18 1979-07-24 Merck & Co., Inc. Antibiotic N-acetyl-dehydro-thienamycin
NZ190994A (en) 1978-07-24 1981-10-19 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates

Also Published As

Publication number Publication date
NL7612933A (en) 1977-05-24
CH625553A5 (en) 1981-09-30
FR2332017A1 (en) 1977-06-17
DE2652677C2 (en) 1985-05-23
JPS5265293A (en) 1977-05-30
JPS6253157B2 (en) 1987-11-09
GB1561109A (en) 1980-02-13
SE426845B (en) 1983-02-14
DK143712C (en) 1982-03-22
FR2332017B1 (en) 1980-04-25
DE2652677A1 (en) 1977-06-02
DK143712B (en) 1981-09-28
DK497176A (en) 1977-05-22

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