GB618826A - Derivatives of 5-aminouracil - Google Patents

Derivatives of 5-aminouracil

Info

Publication number
GB618826A
GB618826A GB3359046A GB3359046A GB618826A GB 618826 A GB618826 A GB 618826A GB 3359046 A GB3359046 A GB 3359046A GB 3359046 A GB3359046 A GB 3359046A GB 618826 A GB618826 A GB 618826A
Authority
GB
United Kingdom
Prior art keywords
uracil
aminouracil
acid
derivative
heated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3359046A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Burroughs Wellcome Co USA
Burroughs Wellcome and Co USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Burroughs Wellcome Co USA, Burroughs Wellcome and Co USA Inc filed Critical Burroughs Wellcome Co USA
Priority to GB3359046A priority Critical patent/GB618826A/en
Publication of GB618826A publication Critical patent/GB618826A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivatives of 5-aminouracil of the general formula <FORM:0618826/IV(b)/1> where R is an acyl radical derived from an a -fluoro-, a -chloro-, a -bromo-, a -hydroxy- or dicarboxylic aliphatic acid having up to six carbon atoms, are prepared by heating 5-aminouracil with the appropriate aliphatic carboxylic acid. In place of 5-aminouracil, a derivative which is hydrolysed to 5-aminouracil by water may be used. Preferably the reactants are heated at 100-140 DEG C. for 1/2 -2 hours and the acid is one having a dissociation constant greater than 10-5. The products are useful as inhibitors of the growth of rinuses and bacteria. In examples, 5-aminouracil or a derivative is heated with the appropriate acid to produce 5-(chloroacetamino)-uracil, 5-(a -chloropropionylamino)-uracil, 5-dichloroacetylamino(-uracil, 5-(fluoroacetylamino)-uracil, 5-(a - chlorobutyrylamino) - uracil, 5 - (a - bromopropionylamino) - uracil, 5 - (dibromoacetylamino) - uracil, 5 - oxalylamino) - uracil, 5-lactylaminouracil and 5-adipylaminouracil.
GB3359046A 1946-11-12 1946-11-12 Derivatives of 5-aminouracil Expired GB618826A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3359046A GB618826A (en) 1946-11-12 1946-11-12 Derivatives of 5-aminouracil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3359046A GB618826A (en) 1946-11-12 1946-11-12 Derivatives of 5-aminouracil

Publications (1)

Publication Number Publication Date
GB618826A true GB618826A (en) 1949-02-28

Family

ID=10354888

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3359046A Expired GB618826A (en) 1946-11-12 1946-11-12 Derivatives of 5-aminouracil

Country Status (1)

Country Link
GB (1) GB618826A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000664A1 (en) * 2001-06-22 2003-01-03 Bayer Aktiengesellschaft Uracil derivatives and the use thereof for treating bacterial diseases

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000664A1 (en) * 2001-06-22 2003-01-03 Bayer Aktiengesellschaft Uracil derivatives and the use thereof for treating bacterial diseases

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