GB610048A - Improvements in or relating to the preparation of labile vinyldiacetonalkamine and to the production of eucatropine hydrochloride therefrom - Google Patents

Improvements in or relating to the preparation of labile vinyldiacetonalkamine and to the production of eucatropine hydrochloride therefrom

Info

Publication number
GB610048A
GB610048A GB24932/45A GB2493245A GB610048A GB 610048 A GB610048 A GB 610048A GB 24932/45 A GB24932/45 A GB 24932/45A GB 2493245 A GB2493245 A GB 2493245A GB 610048 A GB610048 A GB 610048A
Authority
GB
United Kingdom
Prior art keywords
vinyldiacetonalkamine
labile
relating
preparation
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24932/45A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
William R Warner and Co Inc
Original Assignee
William R Warner and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William R Warner and Co Inc filed Critical William R Warner and Co Inc
Publication of GB610048A publication Critical patent/GB610048A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Labile vinyldiacetonalkamine is prepared by hydrogenating vinyldiacetonamine in the presence of a nickel catalyst, preferably with agitation in a solvent, under hydrogen pressures of 1,500-3,000 lbs./sq. in. and at temperatures in excess of 180 DEG C. Examples are given in which the solvent is methanol and the catalyst Raney nickel or nickel pellet. The product may be treated with formaldehyde to form N-methyl-vinyldiacetonalkamine which on treatment with mandelic acid and hydrogen chloride yields the mydriatic eucatropine hydrochloride.
GB24932/45A 1944-10-19 1945-09-26 Improvements in or relating to the preparation of labile vinyldiacetonalkamine and to the production of eucatropine hydrochloride therefrom Expired GB610048A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US610048XA 1944-10-19 1944-10-19

Publications (1)

Publication Number Publication Date
GB610048A true GB610048A (en) 1948-10-11

Family

ID=22033048

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24932/45A Expired GB610048A (en) 1944-10-19 1945-09-26 Improvements in or relating to the preparation of labile vinyldiacetonalkamine and to the production of eucatropine hydrochloride therefrom

Country Status (1)

Country Link
GB (1) GB610048A (en)

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