GB599738A - Improvements in or relating to the preparation of 2-sulfanilamidopyrazine - Google Patents
Improvements in or relating to the preparation of 2-sulfanilamidopyrazineInfo
- Publication number
- GB599738A GB599738A GB10854/45A GB1085445A GB599738A GB 599738 A GB599738 A GB 599738A GB 10854/45 A GB10854/45 A GB 10854/45A GB 1085445 A GB1085445 A GB 1085445A GB 599738 A GB599738 A GB 599738A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sulphanilamide
- sulphanilamidopyrazine
- chloropyrazine
- acidifying
- recovered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C07D241/22—Benzenesulfonamido pyrazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
Abstract
2-Sulphanilamidopyrazine is prepared by reacting sulphanilamide, a halopyrazine and an acid-binding substance such as an alkali metal carbonate or bicarbonate. Temperatures within the range 125 DEG to 175 DEG C. are preferred. In an example, chloropyrazine, sulphanilamide and potassium carbonate are stirred and heated to 130 DEG C. under reflux conditions until the mixture thickens and the temperature rises to 145-150 DEG C. Unreacted chloropyrazine is then recovered by steam distillation, and excess sulphanilamide crystallized out by acidifying to pH 8.0 to 9.5 and cooling to 10 DEG C. The 2-sulphanilamidopyrazine is recovered from the solution by acidifying to pH 5, and purified by dissolving in alkali, treating with activated charcoal and reprecipitating with acid. Halopyrazines may be prepared by the reaction of hydroxypyrazine with a mixture of phosphorus pentachloride and phosphorus oxychloride or by direct halogenation.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US599738XA | 1944-05-16 | 1944-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB599738A true GB599738A (en) | 1948-03-19 |
Family
ID=22026515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB10854/45A Expired GB599738A (en) | 1944-05-16 | 1945-04-30 | Improvements in or relating to the preparation of 2-sulfanilamidopyrazine |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB599738A (en) |
-
1945
- 1945-04-30 GB GB10854/45A patent/GB599738A/en not_active Expired
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