GB593691A - Improvements in or relating to the production of sodium-penicillin - Google Patents

Improvements in or relating to the production of sodium-penicillin

Info

Publication number
GB593691A
GB593691A GB17988/44A GB1798844A GB593691A GB 593691 A GB593691 A GB 593691A GB 17988/44 A GB17988/44 A GB 17988/44A GB 1798844 A GB1798844 A GB 1798844A GB 593691 A GB593691 A GB 593691A
Authority
GB
United Kingdom
Prior art keywords
sodium
penicillin
moisture content
per cent
phosphorus pentoxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB17988/44A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of GB593691A publication Critical patent/GB593691A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/14—Preparation of salts
    • C07D499/16—Preparation of salts of alkali or alkaline earth metals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Sodium-penicillin, characterised by a moisture content less than approximately 2.0 per cent and by high stability, is obtained by subjecting this compound as ordinarily obtained to severe drying conditions, e.g. exposure to high vacuum, in the presence of anhydrous calcium sulphate, magnesium perchlorate, or preferably phosphorus pentoxide, for 24-48 hours at room temperature. In an example: sodium-penicillin solution, obtained by standard methods from culture media carrying selected strains of Penicillium notatum, is frozen and subjected to high vacuum, prior to further drying in a vacuum desiccator over phosphorus pentoxide until the moisture content of the salt falls to about 0.5-1.3 per cent.
GB17988/44A 1943-08-06 1944-09-20 Improvements in or relating to the production of sodium-penicillin Expired GB593691A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US593691XA 1943-08-06 1943-08-06

Publications (1)

Publication Number Publication Date
GB593691A true GB593691A (en) 1947-10-23

Family

ID=22022517

Family Applications (1)

Application Number Title Priority Date Filing Date
GB17988/44A Expired GB593691A (en) 1943-08-06 1944-09-20 Improvements in or relating to the production of sodium-penicillin

Country Status (1)

Country Link
GB (1) GB593691A (en)

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