GB575119A - Process for producing nicotinamide - Google Patents

Process for producing nicotinamide

Info

Publication number
GB575119A
GB575119A GB1416244A GB1416244A GB575119A GB 575119 A GB575119 A GB 575119A GB 1416244 A GB1416244 A GB 1416244A GB 1416244 A GB1416244 A GB 1416244A GB 575119 A GB575119 A GB 575119A
Authority
GB
United Kingdom
Prior art keywords
acid
per cent
temperature
nicotinamide
cyanopyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1416244A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FRANK MANCHESTER
GEIGY COLOUR Co Ltd
ISODORE ELKANAH BALABAN
Original Assignee
FRANK MANCHESTER
GEIGY COLOUR Co Ltd
ISODORE ELKANAH BALABAN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FRANK MANCHESTER, GEIGY COLOUR Co Ltd, ISODORE ELKANAH BALABAN filed Critical FRANK MANCHESTER
Priority to GB1416244A priority Critical patent/GB575119A/en
Publication of GB575119A publication Critical patent/GB575119A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

Nicotinamide is prepared by the partial hydrolysis of 3-cyano pyridine with mineral acid, the hydrolysis being restricted by controlling the temperature and concentration of the acid. Preferably, concentrated (98 per cent) sulphuric acid is employed, the mixture of acid and 3-cyanopyridine being allowed to stand at a temperature not exceeding 30-35 DEG C.; when more dilute acid is employed, higher temperatures can be used, boiling being suitable with 25 per cent sulphuric acid. The temperature on mixing with concentrated sulphuric acid should not exceed 20 DEG C. though may be allowed to rise thereafter to 30 DEG C., but with concentrated hydrochloric acid, the temperature on mixing may be 35 DEG C. After hydrolysis, the reaction mixture is rendered faintly alkaline, for example by the addition of milk of lime, ammonia, or caustic soda, and then preferably treated to remove by-products, for example by filtration or decantation and if necessary extraction with a solvent to remove unchanged 3 - cyanopyridine and then evaporated to dryness. The nicotinamide can be extracted from the dried product with a solvent. Examples describe the partial hydrolysis of 3-cyanopyridine to nicotinamide by means of 98 per cent w/w, 90 per cent w/w, and 25 per cent w/w sulphuric acid and 40 per cent hydrochloric acid.
GB1416244A 1944-07-25 1944-07-25 Process for producing nicotinamide Expired GB575119A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1416244A GB575119A (en) 1944-07-25 1944-07-25 Process for producing nicotinamide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1416244A GB575119A (en) 1944-07-25 1944-07-25 Process for producing nicotinamide

Publications (1)

Publication Number Publication Date
GB575119A true GB575119A (en) 1946-02-07

Family

ID=10036125

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1416244A Expired GB575119A (en) 1944-07-25 1944-07-25 Process for producing nicotinamide

Country Status (1)

Country Link
GB (1) GB575119A (en)

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