GB562349A - Improvements relating to the manufacture of sulphanilamide derivatives - Google Patents
Improvements relating to the manufacture of sulphanilamide derivativesInfo
- Publication number
- GB562349A GB562349A GB237543A GB237543A GB562349A GB 562349 A GB562349 A GB 562349A GB 237543 A GB237543 A GB 237543A GB 237543 A GB237543 A GB 237543A GB 562349 A GB562349 A GB 562349A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ethyl
- sulphanilamidosalicylate
- sulphanilamidobenzoate
- aralkyl
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Sulphanilamido acylamides of the general formula H2N.C6H4.SO2NH.X.CONH2 are prepared by the action of concentrated aqueous ammonia on compounds of the formula R1HN.C6H4.SO2.NR1.X.CO.OR, where X may be an alkyl, aryl, aralkyl or heterocyclic residue, R1 may be hydrogen or acyl and R may be alkyl, aryl, or aralkyl. The reaction is preferably carried out by heating in an autoclave for about two hours at about 150 DEG C. Examples are given of the treatment with ammonia of (1) ethyl 4-sulphanilamidobenzoate; (2) ethyl N1N4-diacetyl-4-sulphanilamidobenzoate; (3) ethyl 3-sulphanilamidocinnamate; (4) ethyl sulphanilamidoacetate; (5) ethyl 5-sulphanilamidosalicylate; (6) ethyl 3-sulphanilamidosalicylate; (7) ethyl 3-aminopicolinate. In each case the corresponding amide is formed with simultaneous regeneration of the free amino groups. Specification 486,421 is referred to.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB237543A GB562349A (en) | 1943-02-12 | 1943-02-12 | Improvements relating to the manufacture of sulphanilamide derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB237543A GB562349A (en) | 1943-02-12 | 1943-02-12 | Improvements relating to the manufacture of sulphanilamide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB562349A true GB562349A (en) | 1944-06-28 |
Family
ID=9738438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB237543A Expired GB562349A (en) | 1943-02-12 | 1943-02-12 | Improvements relating to the manufacture of sulphanilamide derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB562349A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2507474A1 (en) * | 1981-06-16 | 1982-12-17 | Choay Sa | Benzene, thiophene and pyrimidine sulphonamido alkanoic acid derivs. - are normolipaemic cpds. with good therapeutic index, have low toxicity |
FR2507598A1 (en) * | 1981-06-16 | 1982-12-17 | Choay Sa | Benzene, thiophene and pyrimidine sulphonamido alkanoic acid derivs. - are normolipaemic cpds. with good therapeutic index, have low toxicity |
EP0068968A1 (en) * | 1981-06-16 | 1983-01-05 | Choay S.A. | Medicines containing as active ingredients compounds of the arylbenzenesulfonamide-type, and processes for their preparation |
-
1943
- 1943-02-12 GB GB237543A patent/GB562349A/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2507474A1 (en) * | 1981-06-16 | 1982-12-17 | Choay Sa | Benzene, thiophene and pyrimidine sulphonamido alkanoic acid derivs. - are normolipaemic cpds. with good therapeutic index, have low toxicity |
FR2507598A1 (en) * | 1981-06-16 | 1982-12-17 | Choay Sa | Benzene, thiophene and pyrimidine sulphonamido alkanoic acid derivs. - are normolipaemic cpds. with good therapeutic index, have low toxicity |
EP0068968A1 (en) * | 1981-06-16 | 1983-01-05 | Choay S.A. | Medicines containing as active ingredients compounds of the arylbenzenesulfonamide-type, and processes for their preparation |
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