GB547057A - A process for the manufacture of carboxylic acid amides of quaternary ammonium compounds - Google Patents

A process for the manufacture of carboxylic acid amides of quaternary ammonium compounds

Info

Publication number
GB547057A
GB547057A GB657842A GB657842A GB547057A GB 547057 A GB547057 A GB 547057A GB 657842 A GB657842 A GB 657842A GB 657842 A GB657842 A GB 657842A GB 547057 A GB547057 A GB 547057A
Authority
GB
United Kingdom
Prior art keywords
chloride
crotonic acid
betaine
acid betaine
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB657842A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Products Ltd
Original Assignee
Roche Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Products Ltd filed Critical Roche Products Ltd
Priority to GB657842A priority Critical patent/GB547057A/en
Publication of GB547057A publication Critical patent/GB547057A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

547,057. Amides of crotonic acid betaine compounds. ROCHE PRODUCTS, Ltd., BERGEL, F., COHEN, A., and HINDLEY, N. C. Dec. 10, 1940, No. 6578/42. Divided out of 546,596. [Class 2 (iii)] Amides of crotonic acid betaine compounds and quarternary ammonium compounds of similar constitution are prepared by reacting an acid chloride of the general formulawith ammonia, an amine, or an α - amino acid alkyl ester. In the formula R, R<SP>1</SP> and R<SP>11</SP> are identical or different alkyl, aryl, or arakyl groups, X is halogen and n is 1 or.2. In place of the above acid chloride there may be used as starting material a corresponding simple ester. In examples (1) crotonic acid betaine chloride is treated with methyl alcohol in the presence of dry hydrogen chloride and the ester so produced treated with concentrated liquid ammonia to give the quarternary chloride of crotonic acid betaine amide. (2) crotonic acid betaine chloride is converted into the acid chloride and treated with concentrated aqueous ammonia to give the corresponding amide which is purified by its reineckate. (3) The acid chloride of crotonic acid betaine chloride is mixed with dry powdered silica to form a granular solid which is gradually added to an ether solution of the ethyl ester of glycine to give a betaine-peptide of the formula- Specifications 546,596 and 546,613 are referred to.
GB657842A 1940-12-10 1940-12-10 A process for the manufacture of carboxylic acid amides of quaternary ammonium compounds Expired GB547057A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB657842A GB547057A (en) 1940-12-10 1940-12-10 A process for the manufacture of carboxylic acid amides of quaternary ammonium compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB657842A GB547057A (en) 1940-12-10 1940-12-10 A process for the manufacture of carboxylic acid amides of quaternary ammonium compounds

Publications (1)

Publication Number Publication Date
GB547057A true GB547057A (en) 1942-08-11

Family

ID=9817039

Family Applications (1)

Application Number Title Priority Date Filing Date
GB657842A Expired GB547057A (en) 1940-12-10 1940-12-10 A process for the manufacture of carboxylic acid amides of quaternary ammonium compounds

Country Status (1)

Country Link
GB (1) GB547057A (en)

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