GB463647A - Process for the manufacture of complex compounds of 1.3-dimethylxanthine - Google Patents
Process for the manufacture of complex compounds of 1.3-dimethylxanthineInfo
- Publication number
- GB463647A GB463647A GB27323/35A GB2732335A GB463647A GB 463647 A GB463647 A GB 463647A GB 27323/35 A GB27323/35 A GB 27323/35A GB 2732335 A GB2732335 A GB 2732335A GB 463647 A GB463647 A GB 463647A
- Authority
- GB
- United Kingdom
- Prior art keywords
- mol
- alkali metal
- theophylline
- acid
- hydroxybenzoic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Double compounds of theophylline with water-soluble salts of m-hydroxybenzoic acid are prepared by interaction of the components in the presence of a solvent such as water. The products possess therapeutic properties. The process may be effected by (1) reacting 1 mol. of theophylline with 2 mols. of an alkali metal salt or 1 mol. of the neutral magnesium salt of m-hydroxybenzoic acid; (2) treating 1 mol. of theophylline with 2 mols. of m-hydroxybenzoic acid and adding sufficient alkali metal or magnesium hydroxide to give a neutral product; (3) reacting 1 mol. of an alkali metal compound of theophylline with 1 mol. of an alkali metal salt of m-hydroxybenzoic acid and 1 mol. of the free acid, or with 2 mols. of an alkali metal salt of the acid with the addition of one equivalent of a stronger acid. An example is given.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE463647X | 1934-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB463647A true GB463647A (en) | 1937-04-05 |
Family
ID=6540150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27323/35A Expired GB463647A (en) | 1934-10-04 | 1935-10-03 | Process for the manufacture of complex compounds of 1.3-dimethylxanthine |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB463647A (en) |
-
1935
- 1935-10-03 GB GB27323/35A patent/GB463647A/en not_active Expired
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