GB445324A - The manufacture of ergometrinine, a new alkaloid of ergot - Google Patents

The manufacture of ergometrinine, a new alkaloid of ergot

Info

Publication number
GB445324A
GB445324A GB2146035A GB2146035A GB445324A GB 445324 A GB445324 A GB 445324A GB 2146035 A GB2146035 A GB 2146035A GB 2146035 A GB2146035 A GB 2146035A GB 445324 A GB445324 A GB 445324A
Authority
GB
United Kingdom
Prior art keywords
ergot
chloroform
extracting
benzene
ergometrinine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2146035A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB2146035A priority Critical patent/GB445324A/en
Publication of GB445324A publication Critical patent/GB445324A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Ergometrinine, a new alkaloid of ergot, is isolated by rendering alkaline an aqueous acid solution of the total alkaloids of ergot, extracting the resulting precipitate with water or aqueous mineral acid, adding alkali and filtering, and finally extracting the filtrate fractionally with chloroform and evaporating to dryness. The crude product is purified by extracting it with benzene or benzene homologue and/or by trituration with acetone; alternatively, it is selectively extracted with dilute acid in stages, the first extracts made alkaline, and the filtrate then extracted with chloroform and evaporated to dryness. The product is finally purified by crystallization from acetone, methyl alcohol, ethyl alcohol, or mixtures thereof with water, or from benzene or chloroform. Specifications 140,056, 286,400, [both in Class 2 (iii)], 388,529, and 445,325 are referred to.
GB2146035A 1935-07-29 1935-07-29 The manufacture of ergometrinine, a new alkaloid of ergot Expired GB445324A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2146035A GB445324A (en) 1935-07-29 1935-07-29 The manufacture of ergometrinine, a new alkaloid of ergot

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2146035A GB445324A (en) 1935-07-29 1935-07-29 The manufacture of ergometrinine, a new alkaloid of ergot

Publications (1)

Publication Number Publication Date
GB445324A true GB445324A (en) 1936-04-07

Family

ID=10163312

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2146035A Expired GB445324A (en) 1935-07-29 1935-07-29 The manufacture of ergometrinine, a new alkaloid of ergot

Country Status (1)

Country Link
GB (1) GB445324A (en)

Similar Documents

Publication Publication Date Title
Iwadare The Formation of Polyhydroxy-dialdehydes. I. Xylo-trihydroxy-glutaric Dialdehyde and its Derivatives
GB445324A (en) The manufacture of ergometrinine, a new alkaloid of ergot
Chatterjee et al. 385. The isolation and constitution of marmin, a new coumarin from Aegle marmelos, Correa
Narasimhachari et al. A note on the components of the bark of Prunus puddum
Cahn et al. 137. The methylation and ease of ring-fission of rotenone and related substances
Varshney et al. Saponins and sapogenins XVIII—isolation of proceric acid, a new triterpenic acid, from maharashtrian Albizzia procera seeds
Barnett et al. 104. Aminosteroids. Part II. Preparation of 3: 7-diketocholestene
GB555450A (en) Process for the preparation of active glucosides of senna
US3211764A (en) 19-norandrostadienes and method of preparing the same
Heyes et al. 407. Hydroxy-carbonyl compounds. Part XII. 5: 7-Dihydroxycoumarin.
US2346753A (en) Process for the preparation of cardiac glucoside
US2521805A (en) Process for extracting aconitine
GB1214093A (en) Purification of deoxycholic acid
GB566601A (en) Process for the manufacture of crystallized cardiac glucoside from adonis vernalis l.
Deulofeu et al. 192. Studies on argentine plants. Part II. Aspidospermine from Vallesia glabra and Vallesia dichotoma
Friedmann et al. 243. 4-Methoxycinnamylidenepyruvic acid
GB702072A (en) Improvements in or relating to the production of hecogenin from plant material
US2951076A (en) 13-aldehydo- and 13-carboxy-18-nor-4-pregnene-3, 20-dione and derivatives thereof
GB486898A (en) Manufacture of substances resembling vitamines from plants
Corbett et al. 4. The action of lime-water on 3-O-methyl-D-xylose
GB524132A (en) Preparation of uscharidine
GB569140A (en) Sulphanilamide derivative
US2975197A (en) Halogenated pregnadienes
GB753718A (en) Improvements in or relating to the extraction of the medicinally active component oflithospermum erythrorhizon
GB590907A (en) Improved process of manufacturing tanning extract from concentrated sulphite cellulose waste liquor