GB428815A - Process for the manufacture of laevo-ascorbic acid (vitamin-c) - Google Patents
Process for the manufacture of laevo-ascorbic acid (vitamin-c)Info
- Publication number
- GB428815A GB428815A GB29515/34A GB2951534A GB428815A GB 428815 A GB428815 A GB 428815A GB 29515/34 A GB29515/34 A GB 29515/34A GB 2951534 A GB2951534 A GB 2951534A GB 428815 A GB428815 A GB 428815A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- laevo
- keto
- heating
- ascorbic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
Abstract
Ascorbic acid (Vitamin C) is prepared from 2-keto-laevo-gulonic acid or from its derivatives which yield a 2-keto-laevo-gulonic acid on treatment with acids, by heating in the presence of an acid and preferably between a pH of 3,4 and 0,3. Suitable derivatives which may be used instead of the free acid are salts, esters, and methylene-ether-compounds. The convertion takes place from 60 DEG upwards. It is preferred to interrupt the treatment to remove the ascorbic acid soon after it is formed, since it is not stable to prolonged heating. The heating may be carried out without any additions or after dilution with solid or liquid diluents such as sand, salt, water, alcohols, dioxan, glycol ether or glycerine ester. In examples: (1) 2-keto-laevo-gulonic acid is heated in water in an atmosphere of carbon dioxide for two hours, allowed to crystallize and filtered. (2) Diacetone-2-keto-laevo-gulonic acid is heated at 100 DEG C. for 3 hours with 0,2 normal hydrochloric acid. All the acetone is removed in the first half hour. The solution is allowed to cool and seeded. Specification 427,286 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH428815X | 1933-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB428815A true GB428815A (en) | 1935-05-20 |
Family
ID=4514890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB29515/34A Expired GB428815A (en) | 1933-12-09 | 1934-10-15 | Process for the manufacture of laevo-ascorbic acid (vitamin-c) |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB428815A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2491065A (en) * | 1941-12-01 | 1949-12-13 | Tno | Process for producing ascorbic acid from 2-keto-levo-gulonic acid or its derivatives |
| US6610863B2 (en) | 2000-12-22 | 2003-08-26 | Eastman Chemical Company | Continuous process for producing L-ascorbic acid |
| US6740762B2 (en) | 2001-08-24 | 2004-05-25 | Eastman Chemical Company | Process for ascorbic acids using alkaline earth silicate catalysts |
-
1934
- 1934-10-15 GB GB29515/34A patent/GB428815A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2491065A (en) * | 1941-12-01 | 1949-12-13 | Tno | Process for producing ascorbic acid from 2-keto-levo-gulonic acid or its derivatives |
| US6610863B2 (en) | 2000-12-22 | 2003-08-26 | Eastman Chemical Company | Continuous process for producing L-ascorbic acid |
| US6740762B2 (en) | 2001-08-24 | 2004-05-25 | Eastman Chemical Company | Process for ascorbic acids using alkaline earth silicate catalysts |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US2033909A (en) | Manufacture of calcium levulinate | |
| GB428815A (en) | Process for the manufacture of laevo-ascorbic acid (vitamin-c) | |
| GB822834A (en) | A method of processing waste of polyethylene terephthalate by hydrolysis | |
| GB469157A (en) | Process for the manufacture of laevo-ascorbic acid | |
| GB568858A (en) | A process for the manufacture of a cumarin derivative | |
| GB628631A (en) | Process for the recrystallisation of melamine | |
| GB461790A (en) | Process for the manufacture of laevo-ascorbic acid | |
| GB466548A (en) | Process for the manufacture of laevo-ascorbic acid (vitamin-c) | |
| GB417383A (en) | Manufacture of alcohols from marine animal waxes | |
| GB466356A (en) | Improvements relating to the production of pectin | |
| GB453159A (en) | Improvements in or relating to a method of manufacturing solutions of pollen or other vegetable cells | |
| GB445399A (en) | Process for preparing optically active trans-ªð-hydroxycamphor from optically active ª‡-ªð-(trans)-dihalogen-camphor | |
| GB462699A (en) | Manufacture of 6-amino-2-hydroxynaphthalene-3-carboxylic acid | |
| FR809500A (en) | Process for extracting the anhydride resulting from the thermal decomposition of organic acids, and in particular acetic acid | |
| DE1147953B (en) | Process for the preparation of 2, 5-diarylaminoterephthalic acids | |
| GB403554A (en) | Improvements relating to the production of cellulose acetate | |
| GB410649A (en) | Process of preparing purified mucins and solutions thereof | |
| GB537712A (en) | Process for the production of aliphatic acids from their salts | |
| GB382449A (en) | Manufacture of arylamino-2-hydroxy-naphthalene-carboxylic acids | |
| GB390378A (en) | Process for the production of water-soluble vitamin concentrates | |
| GB574872A (en) | Improvements in the manufacture of penicillin | |
| GB482826A (en) | Manufacture of extracts of spleen or liver | |
| GB461322A (en) | Manufacture of compounds of the aetio-cholenone or aetio-allo-cholenone series | |
| AU2358635A (en) | An improved process forthe direct manufacture of acids and esters fromthe calcium salts of formic, propionic and caproic acids | |
| GB437769A (en) | An improved process for making compounds of sulphhydryl keratinic acid and similar reduced degradation products of keratin with organic compounds containing arsenic |