GB425216A - Improvements in or relating to a method of manufacturing bacterial solutions - Google Patents
Improvements in or relating to a method of manufacturing bacterial solutionsInfo
- Publication number
- GB425216A GB425216A GB1636033A GB1636033A GB425216A GB 425216 A GB425216 A GB 425216A GB 1636033 A GB1636033 A GB 1636033A GB 1636033 A GB1636033 A GB 1636033A GB 425216 A GB425216 A GB 425216A
- Authority
- GB
- United Kingdom
- Prior art keywords
- solution
- bacteria
- added
- salt
- per cent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
Abstract
Solutions of bacteria, retaining the antigenic properties of the bacterial toxins, are obtained by dissolving the bacteria in a solution of the sodium salt of the sulphuric ester of lauryl alcohol. The solution may also contain free sodium hydroxide to increase its solvent action on Gram-positive organisms, according to an example a suspension of bacteria in water, standardized as to its bacterial content, is added to a solution made by mixing equal parts of a 2 per cent solution of sulphonated Lorol and a 3,6 per cent solution of sodium hydroxide, and the mixture is allowed to stand at 42 DEG C. The final solution may be adjusted to pH 7,4 with hydrochloric acid and salt may be added to give a physiologically normal solution. The solution may be sterilized. According to the Provisional Specification the final solution may have a buffer salt, such as sodium acetate or phosphate, added.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1636033A GB425216A (en) | 1933-06-07 | 1933-06-07 | Improvements in or relating to a method of manufacturing bacterial solutions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1636033A GB425216A (en) | 1933-06-07 | 1933-06-07 | Improvements in or relating to a method of manufacturing bacterial solutions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB425216A true GB425216A (en) | 1935-03-07 |
Family
ID=10075894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1636033A Expired GB425216A (en) | 1933-06-07 | 1933-06-07 | Improvements in or relating to a method of manufacturing bacterial solutions |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB425216A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2047886A1 (en) * | 1969-06-30 | 1971-03-19 | Merieux Inst | Non-toxic anti-whooping cough vaccine |
| EP3155422B1 (en) | 2014-06-12 | 2019-05-01 | Hyglos Invest GmbH | Unmasking endotoxins in solution |
| US11092592B2 (en) | 2014-06-12 | 2021-08-17 | Biomérieux Deutschland Gmbh | Unmasking endotoxins in solution |
-
1933
- 1933-06-07 GB GB1636033A patent/GB425216A/en not_active Expired
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2047886A1 (en) * | 1969-06-30 | 1971-03-19 | Merieux Inst | Non-toxic anti-whooping cough vaccine |
| EP3155422B1 (en) | 2014-06-12 | 2019-05-01 | Hyglos Invest GmbH | Unmasking endotoxins in solution |
| EP2955518B1 (en) | 2014-06-12 | 2019-05-15 | Hyglos Invest GmbH | Unmasking endotoxins in solution |
| US10697958B2 (en) | 2014-06-12 | 2020-06-30 | Hyglos Invest Gmbh | Unmasking endotoxins in solution |
| US11092592B2 (en) | 2014-06-12 | 2021-08-17 | Biomérieux Deutschland Gmbh | Unmasking endotoxins in solution |
| EP3155422B2 (en) † | 2014-06-12 | 2022-01-26 | bioMérieux Deutschland GmbH | Unmasking endotoxins in solution |
| US11860158B2 (en) | 2014-06-12 | 2024-01-02 | Biomérieux Deutschland Gmbh | Unmasking endotoxins in solution |
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