GB363001A - Improvements in or relating to soluble preparations of cinchona alkaloids - Google Patents

Improvements in or relating to soluble preparations of cinchona alkaloids

Info

Publication number
GB363001A
GB363001A GB2781830A GB2781830A GB363001A GB 363001 A GB363001 A GB 363001A GB 2781830 A GB2781830 A GB 2781830A GB 2781830 A GB2781830 A GB 2781830A GB 363001 A GB363001 A GB 363001A
Authority
GB
United Kingdom
Prior art keywords
anhydride
quinine
base
sarcosin
tablets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2781830A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IG Farbenindustrie AG
Original Assignee
IG Farbenindustrie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IG Farbenindustrie AG filed Critical IG Farbenindustrie AG
Priority to GB2781830A priority Critical patent/GB363001A/en
Publication of GB363001A publication Critical patent/GB363001A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compressed tablets containing salts of cinchona alkaloids are rendered rapidly soluble in water by incorporation of sarcosin anhydride or a homologue thereof with the salt before compression into tablets. According to examples sarcosin anhydride may be added to quinine hydrochloride, to quinine bishydrochloride, or to mixtures of quinine hydrochloride with quinine base or with a mixture of quinidine base, cinchonine base and hydroquinine base, or tablets may be prepared from the complex compound referred to in the parent Specification and obtained by dissolving 1 mol. of quinine hydrochloride and 3 mols. of sarcosine anhydride in benzene and evaporating the solvent. Sarcosin anhydride may be replaced by 1.4-diethyl-2.5-diketopiperazine or 3 methyl-2.5-diketopiperazine.ALSO:Compressed tablets containing salts of cinchona alkaloids are rendered rapidly soluble in water by incorporating sarcosin anhydride or a homologue thereof with the salt before compression into tablet form. According to examples sarcosin anhydride may be added to quinine hydrochloride, to a mixture of quinine hydrochloride and quinine base, to a mixture of quinine hydrochloride, quinidine base, cinchonine base and hydroquinine base, or to quinine bishydrochloride, or tablets may be prepared from the complex compound referred to in the parent Specification and obtained by dissolving 1 mol. of quinine hydrochloride and 3 mols. of sarcosine anhydride in benzene and evaporating the solvent. Sarcosin anhydride may be replaced by 1,4-diethyl-2,5-diketopiperazine, or by 3 methyl-2,5-diketopiperazine. Other ingredients such as amylose, milk sugar, boric acid, or sorbitol or mixtures thereof may be added to the tablets.
GB2781830A 1930-09-17 1930-09-17 Improvements in or relating to soluble preparations of cinchona alkaloids Expired GB363001A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2781830A GB363001A (en) 1930-09-17 1930-09-17 Improvements in or relating to soluble preparations of cinchona alkaloids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2781830A GB363001A (en) 1930-09-17 1930-09-17 Improvements in or relating to soluble preparations of cinchona alkaloids

Publications (1)

Publication Number Publication Date
GB363001A true GB363001A (en) 1931-12-17

Family

ID=10265787

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2781830A Expired GB363001A (en) 1930-09-17 1930-09-17 Improvements in or relating to soluble preparations of cinchona alkaloids

Country Status (1)

Country Link
GB (1) GB363001A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2177913A (en) * 1984-01-26 1987-02-04 Sanofi Sa Anti malarial compositions

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2177913A (en) * 1984-01-26 1987-02-04 Sanofi Sa Anti malarial compositions
GB2177913B (en) * 1984-01-26 1989-08-09 Sanofi Sa Pharmaceutical composition for combating malaria

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