GB665073A - Process of preparing acid-sensitive drugs for oral administration and the product soproduced - Google Patents

Process of preparing acid-sensitive drugs for oral administration and the product soproduced

Info

Publication number
GB665073A
GB665073A GB28083/49A GB2808349A GB665073A GB 665073 A GB665073 A GB 665073A GB 28083/49 A GB28083/49 A GB 28083/49A GB 2808349 A GB2808349 A GB 2808349A GB 665073 A GB665073 A GB 665073A
Authority
GB
United Kingdom
Prior art keywords
gel
drug
formaldehyde
penicillin
resins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28083/49A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JACQUES LOEWE RES FOUNDATION I
Original Assignee
JACQUES LOEWE RES FOUNDATION I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JACQUES LOEWE RES FOUNDATION I filed Critical JACQUES LOEWE RES FOUNDATION I
Publication of GB665073A publication Critical patent/GB665073A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2063—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2873—Proteins, e.g. gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

665,073. Coatings for acid-sensitive drugs. LOEWE RESEARCH FOUNDATION, Inc., J. Nov. 2, 1949 [Nov. 10, 1948; June 3, 1949], Nos. 28083/49 and 28084/49. Class 81 (i). An acid-sensitive drug is prepared in a form suitable for oral administration by incorporating said drug with an anion exchange resin, which is mixed with the drug or used as a coating therefor. Preferably the drug is first dispersed in a gel and the resin incorporated therein or coated thereon. Such a gel may be further coated with a carboxy alkyl cellulose ether. Specified drugs are penicillin salts, e.g. the sodium, aluminium, iron, magnesium and cobalt salts; penicillin, aureomycin, chloromycetin, streptomycin, bacitracin, subtilin, polymyxin, dihydrostreptomycin; hormones, e.g. estrogens; insulin, adrenalin and heparin. The anion-exchange resin may be natural or synthetic, e.g. aminoformaldehyde resins such as aniline formaldehyde, amino-mono-saccharide condensates, guanidine-formaldehyde resins, alkali treated asphalt and the resins disclosed in French Specification 820,969 and Specification 489,173, [Group IV]. Gel-forming colloids are natural gums; agar, starch, gelatine, casein, soya bean protein, yeast protein, blood protein and albumin. The preparation may be in the form of a pill, tablet or capsule. Other ingredients which may be present are talc, starch, cellulose, alkali-soluble water-insoluble cellulose ethers and higher fatty acids, such as oleic, palmitic and stearic acids. In one example, sodium penicillin is added to aqueous gelatine of pH 5 to 7 and temperature 50‹ C., the mixture cooled, dehydrated, the gel so formed treated with formaldehyde and the mass coated first with aniline formaldehyde resin and then with a 12 per cent free carboxy methyl cellulose ether.
GB28083/49A 1948-11-10 1949-11-02 Process of preparing acid-sensitive drugs for oral administration and the product soproduced Expired GB665073A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US665073XA 1948-11-10 1948-11-10

Publications (1)

Publication Number Publication Date
GB665073A true GB665073A (en) 1952-01-16

Family

ID=22069924

Family Applications (1)

Application Number Title Priority Date Filing Date
GB28083/49A Expired GB665073A (en) 1948-11-10 1949-11-02 Process of preparing acid-sensitive drugs for oral administration and the product soproduced

Country Status (1)

Country Link
GB (1) GB665073A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2721827A (en) * 1952-08-29 1955-10-25 Edwin L Gustus Composition containing polyamine resin having adsorbed thereon an anion of para-aminosalicylic acid
DE1093050B (en) * 1958-02-03 1960-11-17 Frosst & Co Charles E Process for the manufacture of a penicillin tablet with extended action
US3087860A (en) * 1958-12-19 1963-04-30 Abbott Lab Method of prolonging release of drug from a precompressed solid carrier
FR2880272A1 (en) * 2005-01-04 2006-07-07 Jean Marc Ruiz PREPARATION CONTAINING MICROPARTICLES OF AN INSOLUBLE POLYMER SALT CARRYING AN ACTIVE INGREDIENT, AND METHOD OF MANUFACTURING THE SAME

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2721827A (en) * 1952-08-29 1955-10-25 Edwin L Gustus Composition containing polyamine resin having adsorbed thereon an anion of para-aminosalicylic acid
DE1093050B (en) * 1958-02-03 1960-11-17 Frosst & Co Charles E Process for the manufacture of a penicillin tablet with extended action
US3087860A (en) * 1958-12-19 1963-04-30 Abbott Lab Method of prolonging release of drug from a precompressed solid carrier
FR2880272A1 (en) * 2005-01-04 2006-07-07 Jean Marc Ruiz PREPARATION CONTAINING MICROPARTICLES OF AN INSOLUBLE POLYMER SALT CARRYING AN ACTIVE INGREDIENT, AND METHOD OF MANUFACTURING THE SAME

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