GB361306A - Manufacture of arylthioglycollic acids - Google Patents
Manufacture of arylthioglycollic acidsInfo
- Publication number
- GB361306A GB361306A GB14990/30A GB1499030A GB361306A GB 361306 A GB361306 A GB 361306A GB 14990/30 A GB14990/30 A GB 14990/30A GB 1499030 A GB1499030 A GB 1499030A GB 361306 A GB361306 A GB 361306A
- Authority
- GB
- United Kingdom
- Prior art keywords
- treated
- acid
- amino
- give
- potash
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
O - Aminoarylmercaptans; o-aminoarylthioglycollic acids. An aryl-substituted thiourea is treated with a halogen to give an aminothiazole compound which is hydrolysed to an o-amino-arylmercaptan, and this converted to an o-aminoarylthioglycollic acid. The thiourea employed as starting material is of the type RNHCSNHR<1>, R being an aryl nucleus substituted or not, and R<1> hydrogen, an alkyl or aryl group. For the hydrolysis of the thiazole compound potash or alkaline carbonates or bicarbonates may be used, and for the last stage chloracetic acid itself or a metallic salt thereof is employed. In examples (1) p-phenetylthiourea is treated with chlorine in carbontetrachloride (or with bromine in chlorbenzene), the product saponified with aqueous potash, and treated with chloracetic acid to give o-amino-p-ethoxyphenylthioglycollic acid anhydride on isolation: (2) p-tolylthiourea is treated with bromine in glacial acetic acid, saponified with aqueous potash, and condensed with chloracetic acid to give 2-amino-5-methylphenylthioglycollic acid anhydride on isolation: (3) o-tolylthiourea is treated with bromine in carbontetrachloride, the press-cake obtained is boiled with alcohol and neutralized, saponified with aqueous potash, and condensed with chloracetic acid to give 5-bromo-2-amino-3-methylphenylthioglycollic acid anhydride on isolation; if the press-cake obtained from the first step is treated with aqueous bisulphite instead of alcohol the final product is 2-amino-3-methylphenylthioglycollic acid anhydride.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US361306XA | 1929-05-15 | 1929-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB361306A true GB361306A (en) | 1931-11-16 |
Family
ID=21886804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB14990/30A Expired GB361306A (en) | 1929-05-15 | 1930-05-15 | Manufacture of arylthioglycollic acids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB361306A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2657231A (en) * | 1950-03-20 | 1953-10-27 | Schenley Ind Inc | Process for producing alkylene-bis-dithio-alkylene and -arylene-dicarboxylic acids |
-
1930
- 1930-05-15 GB GB14990/30A patent/GB361306A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2657231A (en) * | 1950-03-20 | 1953-10-27 | Schenley Ind Inc | Process for producing alkylene-bis-dithio-alkylene and -arylene-dicarboxylic acids |
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