GB348345A - Manufacture of n-methyl compounds of the pyridine series - Google Patents

Manufacture of n-methyl compounds of the pyridine series

Info

Publication number
GB348345A
GB348345A GB12242/30A GB1224230A GB348345A GB 348345 A GB348345 A GB 348345A GB 12242/30 A GB12242/30 A GB 12242/30A GB 1224230 A GB1224230 A GB 1224230A GB 348345 A GB348345 A GB 348345A
Authority
GB
United Kingdom
Prior art keywords
methyl
chloride
pyridine
employed
quinolinium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB12242/30A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IG Farbenindustrie AG
Original Assignee
IG Farbenindustrie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IG Farbenindustrie AG filed Critical IG Farbenindustrie AG
Publication of GB348345A publication Critical patent/GB348345A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/20—Quaternary compounds thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

N-Methyl-pyridinium chlorides are prepared by interaction of methyl chloride with pyridine or a substitution product. Ordinary temperature may be employed, but preferably a raised temperature not exceeding 200 DEG C. The reaction may be effected under pressure and in the pressure of a chloride of copper or iron. A diluent may be employed, such as water, ether, benzene, benzine, tetra- and decahydronaphthalenes. The products are hydroscopic stable salts, which can readily be converted into for instance methylpyridones. Examples are given of the treatment of pyridine, a -picoline, b -methoxypyridine and a a -dichloropyridine with methyl chloride under various conditions. N-Methyl-quinolinium chlorides. The Specification as open to inspection under Sect. 91 (3) (a) states that the corresponding quinolinium compounds can similarly be obtained and includes an example for the preparation of N-methylquinolinium chloride from quinoline. Reference is also made to quinaldine as a starting material. This subject-matter does not appear in the Specification as accepted.
GB12242/30A 1929-04-19 1930-04-17 Manufacture of n-methyl compounds of the pyridine series Expired GB348345A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE348345X 1929-04-19

Publications (1)

Publication Number Publication Date
GB348345A true GB348345A (en) 1931-05-14

Family

ID=6257238

Family Applications (1)

Application Number Title Priority Date Filing Date
GB12242/30A Expired GB348345A (en) 1929-04-19 1930-04-17 Manufacture of n-methyl compounds of the pyridine series

Country Status (3)

Country Link
AT (1) AT131118B (en)
CH (1) CH148112A (en)
GB (1) GB348345A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5183869A (en) * 1990-05-18 1993-02-02 Ciba-Geigy Corporation Hardenable compositions
WO2009047291A2 (en) 2007-10-12 2009-04-16 Politechnika Lódzka Use of quaternary pyridinium salts for inhibiting cancer metastases
WO2018015862A1 (en) 2016-07-18 2018-01-25 Pharmena S.A. 1-methylnicotinamide salts for use in raising the blood levels of adiponectin
WO2018015861A1 (en) 2016-07-18 2018-01-25 Pharmena S.A. 1-methylnicotinamide for the treatment of diseases associated with c-reactive protein
WO2021205341A1 (en) 2020-04-07 2021-10-14 Pharmena S.A. 1-methylnicotinamide for the prevention/treatment of inflammatory airway diseases

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5183869A (en) * 1990-05-18 1993-02-02 Ciba-Geigy Corporation Hardenable compositions
WO2009047291A2 (en) 2007-10-12 2009-04-16 Politechnika Lódzka Use of quaternary pyridinium salts for inhibiting cancer metastases
WO2018015862A1 (en) 2016-07-18 2018-01-25 Pharmena S.A. 1-methylnicotinamide salts for use in raising the blood levels of adiponectin
WO2018015861A1 (en) 2016-07-18 2018-01-25 Pharmena S.A. 1-methylnicotinamide for the treatment of diseases associated with c-reactive protein
WO2021205341A1 (en) 2020-04-07 2021-10-14 Pharmena S.A. 1-methylnicotinamide for the prevention/treatment of inflammatory airway diseases

Also Published As

Publication number Publication date
AT131118B (en) 1933-01-10
CH148112A (en) 1931-07-15

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