GB2618220A - Retinol compositions, methods of their preparation and use - Google Patents
Retinol compositions, methods of their preparation and use Download PDFInfo
- Publication number
- GB2618220A GB2618220A GB2307416.4A GB202307416A GB2618220A GB 2618220 A GB2618220 A GB 2618220A GB 202307416 A GB202307416 A GB 202307416A GB 2618220 A GB2618220 A GB 2618220A
- Authority
- GB
- United Kingdom
- Prior art keywords
- composition
- retinol
- skin
- combinations
- ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract 89
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 title claims abstract 44
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 title claims abstract 22
- 229960003471 retinol Drugs 0.000 title claims abstract 22
- 235000020944 retinol Nutrition 0.000 title claims abstract 22
- 239000011607 retinol Substances 0.000 title claims abstract 22
- 238000000034 method Methods 0.000 title claims 22
- 238000002360 preparation method Methods 0.000 title claims 3
- 229940061720 alpha hydroxy acid Drugs 0.000 claims abstract 13
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims abstract 13
- 239000003974 emollient agent Substances 0.000 claims abstract 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract 10
- 230000003750 conditioning effect Effects 0.000 claims abstract 10
- 239000003995 emulsifying agent Substances 0.000 claims abstract 10
- 239000000839 emulsion Substances 0.000 claims abstract 9
- 239000003381 stabilizer Substances 0.000 claims abstract 9
- 239000003963 antioxidant agent Substances 0.000 claims abstract 7
- 235000006708 antioxidants Nutrition 0.000 claims abstract 7
- 230000003078 antioxidant effect Effects 0.000 claims abstract 6
- 239000003125 aqueous solvent Substances 0.000 claims abstract 6
- 239000004615 ingredient Substances 0.000 claims 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 12
- 238000004806 packaging method and process Methods 0.000 claims 8
- 235000013399 edible fruits Nutrition 0.000 claims 7
- 235000011187 glycerol Nutrition 0.000 claims 6
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims 5
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 5
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 5
- 235000019198 oils Nutrition 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 4
- 244000020551 Helianthus annuus Species 0.000 claims 4
- 235000003222 Helianthus annuus Nutrition 0.000 claims 4
- 240000000950 Hippophae rhamnoides Species 0.000 claims 4
- 235000003145 Hippophae rhamnoides Nutrition 0.000 claims 4
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims 4
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 claims 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims 4
- 239000003906 humectant Substances 0.000 claims 4
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 4
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims 4
- 238000003860 storage Methods 0.000 claims 4
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 4
- XLPLFRLIWKRQFT-XUJYDZMUSA-N (3,3-dimethyl-2-oxobutyl) (2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoate Chemical group CC(C)(C)C(=O)COC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C XLPLFRLIWKRQFT-XUJYDZMUSA-N 0.000 claims 3
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims 3
- 244000080152 Drimys aromatica Species 0.000 claims 3
- 235000008496 Drimys aromatica Nutrition 0.000 claims 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 3
- ILRKKHJEINIICQ-OOFFSTKBSA-N Monoammonium glycyrrhizinate Chemical compound N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ILRKKHJEINIICQ-OOFFSTKBSA-N 0.000 claims 3
- 244000044822 Simmondsia californica Species 0.000 claims 3
- 235000004433 Simmondsia californica Nutrition 0.000 claims 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 235000001785 ferulic acid Nutrition 0.000 claims 3
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims 3
- 229940114124 ferulic acid Drugs 0.000 claims 3
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims 3
- 239000001685 glycyrrhizic acid Substances 0.000 claims 3
- 229940119204 hibiscus sabdariffa flower extract Drugs 0.000 claims 3
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 claims 3
- 229910052708 sodium Inorganic materials 0.000 claims 3
- 239000011734 sodium Substances 0.000 claims 3
- 235000010384 tocopherol Nutrition 0.000 claims 3
- 229960001295 tocopherol Drugs 0.000 claims 3
- 229930003799 tocopherol Natural products 0.000 claims 3
- 239000011732 tocopherol Substances 0.000 claims 3
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims 3
- 229940035936 ubiquinone Drugs 0.000 claims 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 2
- 229960000541 cetyl alcohol Drugs 0.000 claims 2
- 229940110767 coenzyme Q10 Drugs 0.000 claims 2
- -1 dimethocone Chemical compound 0.000 claims 2
- 238000004299 exfoliation Methods 0.000 claims 2
- 229940075529 glyceryl stearate Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000003002 pH adjusting agent Substances 0.000 claims 2
- 229940100460 peg-100 stearate Drugs 0.000 claims 2
- 239000011148 porous material Substances 0.000 claims 2
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 claims 2
- 229940108325 retinyl palmitate Drugs 0.000 claims 2
- 235000019172 retinyl palmitate Nutrition 0.000 claims 2
- 239000011769 retinyl palmitate Substances 0.000 claims 2
- 229940010747 sodium hyaluronate Drugs 0.000 claims 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 2
- 229940104261 taurate Drugs 0.000 claims 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 235000002566 Capsicum Nutrition 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000016942 Elastin Human genes 0.000 claims 1
- 108010014258 Elastin Proteins 0.000 claims 1
- 239000006002 Pepper Substances 0.000 claims 1
- 235000016761 Piper aduncum Nutrition 0.000 claims 1
- 235000017804 Piper guineense Nutrition 0.000 claims 1
- 244000203593 Piper nigrum Species 0.000 claims 1
- 235000008184 Piper nigrum Nutrition 0.000 claims 1
- 206010040829 Skin discolouration Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- XJKITIOIYQCXQR-SCUNHAKFSA-N all-trans-retinyl linoleate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C XJKITIOIYQCXQR-SCUNHAKFSA-N 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 229940008099 dimethicone Drugs 0.000 claims 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 1
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 1
- 229920002549 elastin Polymers 0.000 claims 1
- 238000000265 homogenisation Methods 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 230000003810 hyperpigmentation Effects 0.000 claims 1
- 208000000069 hyperpigmentation Diseases 0.000 claims 1
- 230000007794 irritation Effects 0.000 claims 1
- CBKLICUQYUTWQL-XWGBWKJCSA-N methyl (3s,4r)-3-methyl-1-(2-phenylethyl)-4-(n-propanoylanilino)piperidine-4-carboxylate;oxalic acid Chemical compound OC(=O)C(O)=O.CCC(=O)N([C@]1([C@H](CN(CCC=2C=CC=CC=2)CC1)C)C(=O)OC)C1=CC=CC=C1 CBKLICUQYUTWQL-XWGBWKJCSA-N 0.000 claims 1
- 229940031722 methyl gluceth-20 Drugs 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 238000010979 pH adjustment Methods 0.000 claims 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 1
- 229960000342 retinol acetate Drugs 0.000 claims 1
- 235000019173 retinyl acetate Nutrition 0.000 claims 1
- 239000011770 retinyl acetate Substances 0.000 claims 1
- 125000000946 retinyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])=C([H])/C([H])=C(C([H])([H])[H])/C([H])=C([H])/C1=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 229940071220 retinyl linoleate Drugs 0.000 claims 1
- 210000004761 scalp Anatomy 0.000 claims 1
- 210000002374 sebum Anatomy 0.000 claims 1
- 230000037307 sensitive skin Effects 0.000 claims 1
- 230000036548 skin texture Effects 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
Classifications
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
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- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A61K8/34—Alcohols
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Abstract
A composition including 0.01-0.2% w/w retinol, 5-20% w/w alpha hydroxy acid, at least one emollient, at least one aqueous solvent, at least one emulsifying agent, at least one antioxidant, optionally at least one emulsion stabiliser, and optionally at least one skin conditioning agent, wherein the composition has a pH of 3.5 to 4.5.
Claims (52)
1. A composition including 0.01-0.2% w/w one or more retinol ingredient, 5-20% w/w one or more alpha hydroxy acid, at least one emollient, at least one aqueous solvent, at least one emulsifying agent, at least one antioxidant, optionally at least one emulsion stabiliser, and optionally at least one skin conditioning agent, wherein the composition has a pH of 3.5 to 4.5.
2. The composition of claim 1 , wherein the pH is 3.9 to 4.1 , preferably the pH is about 4.
3. The composition of claim 1 or claim 2, wherein the one or more retinol ingredient is hydroxypinacolone retinoate, retinol, retinyl acetate, retinyl linoleate, retinyl palmitate, retinyl proprionate, or combinations thereof.
4. The composition of any one of the preceding claims, wherein the one or more retinol ingredient is hydroxypinacolone retinoate, retinol, or combinations thereof.
5. The composition of any one of the preceding claims, wherein the one or more retinol ingredient is hydroxypinacolone retinoate, retinyl palmitate, retinyl propionate, retinol, or combinations thereof.
6. The composition of any one of the preceding claims, wherein the alpha hydroxy acid is glycolic acid.
7. The composition of any one of the preceding claims, wherein the one or more retinol ingredient is 0.07-0.15% w/w of the composition, preferably is about 0.1% w/w of the composition.
8. The composition of any one of the preceding claims, wherein the composition is 12-16% w/w of one or more alpha hydroxy acid, preferably the composition is about 14% w/w of one or more alpha hydroxy acid
9. The composition of any one of the preceding claims, wherein the at least one emollient is 8-15% w/w of the composition and optionally selected from the group consisting of glycerin, dimethocone, dicaprylyl carbonate, helianthus annuus seed oil, hippophae rhamnoides fruit extract and combinations thereof. Optionally, at least one emollient comprises all of the group consisting of glycerin, dimethocone, dicaprylyl carbonate, helianthus annuus seed oil, and hippophae rhamnoides fruit extract.
10. The composition of any one of the preceding claims, wherein the aqueous solvent is water and the water is 40-70% w/w of the composition, preferably the composition is about 55% w/w water.
11. The composition of any one of the preceding claims, wherein the at least one emulsifying agent is 1.0-2.5% w/w of the composition, preferably about 2% w/w of the composition.
12. The composition of any one of the preceding claims, wherein at least one emulsifying agent is selected from the group consisting of cetyl alcohol, glyceryl stearate, PEG-100 stearate, and combinations thereof.
13. The composition of any one of the preceding claims, wherein the at least one antioxidant is optionally 0.5-2.0% w/w of the composition, preferably about 0.6% w/w.
14. The composition of any one of the preceding claims, wherein the at least one antioxidant is selected from the group consisting of ubiquinone (coenzyme Q10), ferulic acid, Tasmannia lanceolata fruit/leaf extract, and combinations thereof.
15. The composition of any one of the preceding claims, wherein the at least one emulsion stabiliser is 0.5-1 .5% w/w of the composition, preferably about 1 % w/w of the composition.
16. The composition of any one of the preceding claims, wherein the at least one emulsion stabiliser is sodium polyacryloyldimethyl taurate.
17. The composition of any one of the preceding claims, wherein the at least one skin conditioning agent is about 12-17% w/w of the composition.
18. The composition of any one of the preceding claims, wherein the at least one skin conditioning agent is selected from the group consisting of palmitoyl tripepetide-5, hydrolysed jojoba esters, tocopherol, hibiscus sabdariffa flower extract, ammonium glycyrrhizate, sodium hyaluronate, butylene glycol, propanediol and combinations thereof.
19. A composition including: - 0.05-0.2% w/w (preferably 0.1 % w/w) one or more retinol ingredient; or 0.5-2.0% w/w (preferably 1.0% w/w) of a retinol composition comprising 10% one or more retinol ingredient in 90% dimethyl isosorbide, - 10-20% w/w (preferably 14% w/w) one or more alpha hydroxy acid, - 0.001-0.003% w/w (preferably 0.002%) palmitoyl tripepetide-5, - 0.5-2.0% w/w (preferably 0.6%) of at least one antioxidant selected from ubiquinone (coenzyme Q10), ferulic acid, Tasmannia lanceolata fruit/leaf extract, and combinations thereof, - 8-15% w/w (preferably 10-11 % w/w) of at least one emollient, - 1.0-2.5% (preferably 2%) of at least one emulsifying agent, - 0.5-1.5% w/w of at least one emulsion stabiliser - at least one aqueous solvent; and - at least one skin conditioning agent, wherein the composition has a pH of 3.9 to 4.1 (preferably, the pH is about 4).
20. The composition of claim 19, wherein the at least one antioxidant includes: - 0.5-1.5% w/w (preferably 1 % w/w) Tazman Pepper (70% water, 28% glycerin and 2% Tasmannia lanceolata fruit/leaf extract), - 0.005-0.15% w/w (preferable 0.1% w.w) ubiquinone, and - 0.3-0.7% w/w (preferably 0.5% w/w) ferulic acid.
21. The composition of claim 19 or claim 20, wherein the at least one emollient is selected from glycerin, dimethocone, dicaprylyl carbonate, helianthus annuus seed oil, hippophae rhamnoides fruit extract, and combinations thereof.
22. The composition of any one of claims 19-21 , wherein the at least one emulsifying agent selected from cetyl alcohol, glyceryl stearate, PEG-100 stearate, and combinations thereof.
23. The composition of any one of claims 19-22, wherein the at least one emulsion stabiliser selected from sodium polyacryloyldimethyl taurate.
24. The composition of any one of claims 19-23, wherein the at least one aqueous solvent is 50-60% w/w of the composition (preferably about 55% w/w).
25. The composition of any one of claims 19-23, wherein the at least one skin conditioning agent selected from palmitoyl tripepetide-5, hydrolysed jojoba esters, tocopherol, hibiscus sabdariffa flower extract, ammonium glycyrrhizate, sodium hyaluronate, butylene glycol, propanediol and combinations thereof.
26. The composition of any one of claims 19-23, wherein the at least one skin conditioning agent is 5-20% w/w (preferably 12-17% w/w of the composition).
27. The composition of any one of claims 19-23, wherein 90, 95, 98, 99 or 99.5% w/w of the one or more retinol ingredient added to the composition remains retinol ingredient following preparation of the composition.
28. The composition of any one of claims 19-23, wherein 70, 80, 85 or 90% w/w of the one or more alpha hydroxy acid added to the composition remains alpha hydroxy acid following preparation of the composition.
29. The composition of any one of claims 19-23, wherein the composition is stored in an opaque inert packaging and 70, 80, 85, 90, 95, or 98% w/w of the one or more retinol ingredient added to the composition remains retinol ingredient following storage of the composition in its packaging at room temperature and relative humidity for 90 days.
30. The composition of any one of claims 19-23, wherein the composition is stored in an opaque inert packaging and 70, 80, 85 or 90% w/w of the one or more alpha hydroxy acid added to the composition remains alpha hydroxy acid following storage of the composition in its packaging at 40 +/- 2 °C at 75% relative humidity for 90 days. 39
31. The composition of any one of claims 19-23, wherein the composition is stored in an opaque inert packaging and at least 70% w/w (preferably at least 75% w/w) of the one or more retinol ingredient added to the composition remains retinol ingredient following storage of the composition in its packaging at room temperature and standard relative humidity for 12 months.
32. The composition of any one of claims 19-23, wherein the composition is stored in an opaque inert packaging and at least 70% w/w (preferably at least 80% w/w) of the one or more alpha hydroxy acid added to the composition remains alpha hydroxy acid following storage of the composition in opaque inert packaging at room temperature and standard relative humidity for 12 months.
33. A method of exfoliating the skin comprising application of a composition according to any one of claims 1-32 to the skin.
34. A method of exfoliating the skin and one or more of (i) skin lightening by breaking down of hyperpigmentation, (ii) reducing of pore numbers and/or pore size, (iii) improving the skin's texture, (iv) increasing collagen and/or elastin production in the skin, (v) reducing fine lines and/or wrinkles, (vi) reducing sebum production, (vii) improving acne breakouts and blemishes, (viii) increasing hydration and/or a plumping the skin comprising application of a composition according to any one of claims 1-30 to the skin.
35. The method of claim 33 or claim 34, wherein 0.3 ml of the composition is applied to the face, neck, decolletage and/or scalp.
36. The method of any one of claim 33-35, wherein the composition is applied once per day.
37. The method of any one of claim 33-36, wherein the composition has similar irritation levels to the use of the same composition containing no retinol.
38. The method of any one of claim 33-37, wherein the method results in exfoliation of the skin that is 30%, 40% or 50% faster than natural exfoliation of the skin.
39. A method of preparing the composition according to any one of claims 1-32 comprising: 40 (i) combining the one or more alpha hydroxy acid and the at least one aqueous solvent and, if needed, adjusting the pH to 3.8-4.2 using a pH adjuster; (ii) optionally combining the mixture prepared in step (i) with one or more water soluble emollients, one or more skin conditioning agents, one or more humectants, or combinations thereof; (iii) combining the at least one emulsifying agent, at least one oil phase emollient, and optionally at least one emulsion stabiliser with the mixture prepared in step (ii) and homogenising; (iv) combining the one or more antioxidants, one or more retinol ingredient, and optionally one or more heat or shear sensitive ingredients such as skin conditioning agents into the mixture prepared in step (iii); (v) if needed, adjusting the pH to 3.8-4.2 using a pH adjuster.
40. The method of claim 39, wherein the mixture is heated to 60-80 °C (preferably about 70 °C) after step (i) and then cooled after step (iii) 45 °C or less (preferably about 40 °C).
41. The method of claim 39 or claim 40, wherein the heat or sheer sensitive skin conditioning agents added in step (iv) are one or more of tocopherol, hibiscus sabdariffa flower extract, and palmitoyl tripepetide-5.
42. The method of any one of claims 39-41 , wherein one or more of glycerin, butylene glycol, propanediol and sodium hyalonurate are combined with mixture (i) in step (ii).
43. The method of claim 41 , wherein following the inclusion of the one or more of glycerin, butylene glycol, propanediol and hyaluronic acid, one or more humectant is added to the mixture.
44. The method of claim 43, wherein the humectant is methyl gluceth-20.
45. The method of claim 43 or claim 44, wherein humectant is added with one or more skin conditioner, preferably, ammonium glycyrrhizate. 41
46. The method of any one of claims 39-45, wherein the at least one emulsifying agent and at least one oil phase emollient are combined before mixing with mixture of step (ii).
47. The method of claim 46, wherein the at least one emulsifying agent and at least one oil phase emollient are heated to 60-80 °C (preferably about 70 °C) before combining with the mixture of step (ii).
48. The method of any one of claims 39-47, wherein the at least one oil phase emollient is dimethicone and/or dicaprylyl carbonate.
49. The method of any one of claims 39-48, wherein the at least one emulsifying agent and at least one oil phase emollient is added to the mixture of step (ii) and homogenised, then the emulsion stabiliser is added to the mixture and the mixture homogenised again.
50. The method of claims 49, wherein the emulsion stabiliser is combined to the mixture with the emollients helianthus annuus seed oil, and/or hippophae rhamnoides fruit extract, and/or the skin conditioner hydrolysed jojoba esters.
51. The method of any one of claims 39-50, wherein homogenisation is for 5 minutes.
52. The method of any one of claims 39-50, wherein the one or more retinol ingredient is the final ingredient added to the composition before the final pH adjustment.
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|---|---|---|---|
| AU2020903892A AU2020903892A0 (en) | 2020-10-27 | Retinol compositions, methods of their preparation and use | |
| PCT/AU2021/051249 WO2022087666A1 (en) | 2020-10-27 | 2021-10-27 | Retinol compositions, methods of their preparation and use |
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| GB202307416D0 GB202307416D0 (en) | 2023-07-05 |
| GB2618220A true GB2618220A (en) | 2023-11-01 |
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| CN115154373B (en) * | 2022-08-05 | 2023-03-21 | 广州夕木生物科技有限公司 | Anti-aging composition and preparation method thereof |
| CN117582383B (en) * | 2023-11-30 | 2024-07-26 | 梅晔生物医药股份有限公司 | Composition for improving skin aging, application thereof and daily chemical product |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998014167A1 (en) * | 1996-10-03 | 1998-04-09 | Johnson & Johnson Consumer Companies, Inc. | Cosmetic compositions |
| US5932229A (en) * | 1996-04-25 | 1999-08-03 | Avon Products, Inc. | Oxa diacids and related compounds for treating skin conditions |
| EP1449514A1 (en) * | 2003-02-13 | 2004-08-25 | Beiersdorf AG | Skin care compositions with retinoids, ubiquinones, and biotin or carnitine |
| WO2006048671A1 (en) * | 2004-11-05 | 2006-05-11 | Bioforskning As | Polyamine compositions |
| WO2007104981A1 (en) * | 2006-03-14 | 2007-09-20 | Bioforskning Pharma As | Use of polyamines in the treatment of psoriasis |
| US8357382B1 (en) * | 2009-04-02 | 2013-01-22 | Hilt Bethany L | Cosmetic formulations |
-
2021
- 2021-10-27 WO PCT/AU2021/051249 patent/WO2022087666A1/en active Application Filing
- 2021-10-27 GB GB2307416.4A patent/GB2618220A/en active Pending
- 2021-10-27 AU AU2021369845A patent/AU2021369845A1/en active Pending
Patent Citations (6)
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| US5932229A (en) * | 1996-04-25 | 1999-08-03 | Avon Products, Inc. | Oxa diacids and related compounds for treating skin conditions |
| WO1998014167A1 (en) * | 1996-10-03 | 1998-04-09 | Johnson & Johnson Consumer Companies, Inc. | Cosmetic compositions |
| EP1449514A1 (en) * | 2003-02-13 | 2004-08-25 | Beiersdorf AG | Skin care compositions with retinoids, ubiquinones, and biotin or carnitine |
| WO2006048671A1 (en) * | 2004-11-05 | 2006-05-11 | Bioforskning As | Polyamine compositions |
| WO2007104981A1 (en) * | 2006-03-14 | 2007-09-20 | Bioforskning Pharma As | Use of polyamines in the treatment of psoriasis |
| US8357382B1 (en) * | 2009-04-02 | 2013-01-22 | Hilt Bethany L | Cosmetic formulations |
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| DATABASE GNPS [Online] MINTEL; May 2017 (2017-05), "Radiance Boost Treatment", Database accession no. 4744941 See Product Description, Ingredients * |
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| AU2021369845A9 (en) | 2024-10-17 |
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