GB2589049C - Anti-IgE antibodies - Google Patents

Anti-IgE antibodies Download PDF

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Publication number
GB2589049C
GB2589049C GB1905150.7A GB201905150A GB2589049C GB 2589049 C GB2589049 C GB 2589049C GB 201905150 A GB201905150 A GB 201905150A GB 2589049 C GB2589049 C GB 2589049C
Authority
GB
United Kingdom
Prior art keywords
ige antibodies
ige
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1905150.7A
Other languages
English (en)
Other versions
GB2589049A (en
GB201905150D0 (en
GB2589049B (en
Inventor
Saunders Michael
Bigirimana Rene
Blanchetot Christophe
Cromheecke Marijn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ArgenX BVBA
Original Assignee
ArgenX BVBA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ArgenX BVBA filed Critical ArgenX BVBA
Priority to GB1905150.7A priority Critical patent/GB2589049C/en
Publication of GB201905150D0 publication Critical patent/GB201905150D0/en
Priority to EA202192785A priority patent/EA202192785A1/ru
Priority to MA055600A priority patent/MA55600A/fr
Priority to MX2021012457A priority patent/MX2021012457A/es
Priority to JP2021559827A priority patent/JP7586833B2/ja
Priority to SG11202110247XA priority patent/SG11202110247XA/en
Priority to PCT/EP2020/060240 priority patent/WO2020208177A1/en
Priority to PH1/2021/552545A priority patent/PH12021552545A1/en
Priority to AU2020271405A priority patent/AU2020271405A1/en
Priority to CN202080038130.8A priority patent/CN113939540A/zh
Priority to US17/598,033 priority patent/US20220177604A1/en
Priority to BR112021020329A priority patent/BR112021020329A2/pt
Priority to CA3133941A priority patent/CA3133941A1/en
Priority to EP20718649.5A priority patent/EP3953396A1/en
Priority to KR1020217034261A priority patent/KR20210150430A/ko
Publication of GB2589049A publication Critical patent/GB2589049A/en
Priority to IL287035A priority patent/IL287035A/en
Application granted granted Critical
Publication of GB2589049B publication Critical patent/GB2589049B/en
Publication of GB2589049C publication Critical patent/GB2589049C/en
Priority to US19/257,976 priority patent/US20250388699A1/en
Priority to US19/258,059 priority patent/US20250388700A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GB1905150.7A 2019-04-11 2019-04-11 Anti-IgE antibodies Active GB2589049C (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
GB1905150.7A GB2589049C (en) 2019-04-11 2019-04-11 Anti-IgE antibodies
US17/598,033 US20220177604A1 (en) 2019-04-11 2020-04-09 ANTI-IgE ANTIBODIES
CA3133941A CA3133941A1 (en) 2019-04-11 2020-04-09 Anti-ige antibodies
MX2021012457A MX2021012457A (es) 2019-04-11 2020-04-09 Anticuerpos anti-ige.
JP2021559827A JP7586833B2 (ja) 2019-04-11 2020-04-09 抗ＩｇＥ抗体
SG11202110247XA SG11202110247XA (en) 2019-04-11 2020-04-09 ANTI-IgE ANTIBODIES
PCT/EP2020/060240 WO2020208177A1 (en) 2019-04-11 2020-04-09 ANTI-IgE ANTIBODIES
PH1/2021/552545A PH12021552545A1 (en) 2019-04-11 2020-04-09 ANTI-IgE ANTIBODIES
AU2020271405A AU2020271405A1 (en) 2019-04-11 2020-04-09 Anti-IgE antibodies
CN202080038130.8A CN113939540A (zh) 2019-04-11 2020-04-09 抗IgE抗体
EA202192785A EA202192785A1 (ru) 2019-04-11 2020-04-09 АНТИТЕЛА К IgE
BR112021020329A BR112021020329A2 (pt) 2019-04-11 2020-04-09 Anticorpos anti-ige
MA055600A MA55600A (fr) 2019-04-11 2020-04-09 Anticorps anti-ige
EP20718649.5A EP3953396A1 (en) 2019-04-11 2020-04-09 Anti-ige antibodies
KR1020217034261A KR20210150430A (ko) 2019-04-11 2020-04-09 항-IgE 항체
IL287035A IL287035A (en) 2019-04-11 2021-10-06 Anti-ige antibodies
US19/257,976 US20250388699A1 (en) 2019-04-11 2025-07-02 Variant fc regions
US19/258,059 US20250388700A1 (en) 2019-04-11 2025-07-02 Variant fc regions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1905150.7A GB2589049C (en) 2019-04-11 2019-04-11 Anti-IgE antibodies

Publications (4)

Publication Number Publication Date
GB201905150D0 GB201905150D0 (en) 2019-05-29
GB2589049A GB2589049A (en) 2021-05-26
GB2589049B GB2589049B (en) 2023-12-13
GB2589049C true GB2589049C (en) 2024-02-21

Family

ID=66809886

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1905150.7A Active GB2589049C (en) 2019-04-11 2019-04-11 Anti-IgE antibodies

Country Status (16)

Country Link
US (3) US20220177604A1 (https=)
EP (1) EP3953396A1 (https=)
JP (1) JP7586833B2 (https=)
KR (1) KR20210150430A (https=)
CN (1) CN113939540A (https=)
AU (1) AU2020271405A1 (https=)
BR (1) BR112021020329A2 (https=)
CA (1) CA3133941A1 (https=)
EA (1) EA202192785A1 (https=)
GB (1) GB2589049C (https=)
IL (1) IL287035A (https=)
MA (1) MA55600A (https=)
MX (1) MX2021012457A (https=)
PH (1) PH12021552545A1 (https=)
SG (1) SG11202110247XA (https=)
WO (1) WO2020208177A1 (https=)

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BR112022013554A2 (pt) 2020-01-08 2022-09-06 argenx BV Métodos para tratar distúrbios do pênfigo
AU2022310356A1 (en) 2021-07-14 2024-01-25 Lycia Therapeutics, Inc. Asgpr cell surface receptor binding compounds and conjugates
EP4431528A1 (en) * 2021-10-29 2024-09-18 Longbio Pharma (Suzhou) Co., Ltd. Isolated antigen binding protein and use thereof
CA3258000A1 (en) 2022-06-15 2023-12-21 argenx BV FCRN/ANTIGEN BINDING MOLECULES AND METHODS OF USE
GB2635291A (en) 2022-07-01 2025-05-07 Alk Abello As Displacers of IgE-FCERI
CN115724951B (zh) * 2022-11-15 2023-10-03 怡道生物科技(苏州)有限公司 与11型hpv结合的抗体或其抗原结合片段及其应用
JP2026503461A (ja) * 2023-01-18 2026-01-29 ライシア セラピューティクス， インコーポレイテッド サイクリングリソソーム標的化抗体コンジュゲート
CN118725128B (zh) * 2023-03-28 2025-09-16 东莞市朋志生物科技有限公司 抗IgE抗体、检测IgE的试剂和试剂盒
CN119490594B (zh) * 2023-08-15 2025-09-16 东莞市朋志生物科技有限公司 一种抗免疫球蛋白e的抗体及其应用
EP4530295A3 (en) * 2023-09-07 2025-05-28 argenx BV Fcrn antagonists and methods of use
GB202318512D0 (en) * 2023-12-04 2024-01-17 argenx BV Methods of determining potency
WO2025229224A1 (en) * 2024-05-03 2025-11-06 argenx BV Monovalent anti-iga binding molecules and methods of use
US12509529B2 (en) 2024-05-17 2025-12-30 Excellergy, Inc. Antibodies and antibody fragments that bind IgE
WO2025255496A1 (en) * 2024-06-07 2025-12-11 Nuvig Therapeutics, Inc. Modified fc polypeptides
WO2026015664A1 (en) * 2024-07-10 2026-01-15 Lycia Therapeutics, Inc. Cycling lysosomal targeting chimeras targeting immunoglobulin e (ige)

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Also Published As

Publication number Publication date
GB2589049A (en) 2021-05-26
JP7586833B2 (ja) 2024-11-19
GB201905150D0 (en) 2019-05-29
US20250388700A1 (en) 2025-12-25
PH12021552545A1 (en) 2022-07-04
EP3953396A1 (en) 2022-02-16
SG11202110247XA (en) 2021-10-28
MA55600A (fr) 2022-02-16
AU2020271405A1 (en) 2021-10-14
WO2020208177A1 (en) 2020-10-15
US20220177604A1 (en) 2022-06-09
MX2021012457A (es) 2022-01-04
EA202192785A1 (ru) 2022-03-03
GB2589049B (en) 2023-12-13
JP2022528927A (ja) 2022-06-16
CA3133941A1 (en) 2020-10-15
BR112021020329A2 (pt) 2021-12-14
US20250388699A1 (en) 2025-12-25
KR20210150430A (ko) 2021-12-10
IL287035A (en) 2021-12-01
CN113939540A (zh) 2022-01-14

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