GB2577723A - Compounds for new use - Google Patents

Compounds for new use Download PDF

Info

Publication number
GB2577723A
GB2577723A GB1816196.8A GB201816196A GB2577723A GB 2577723 A GB2577723 A GB 2577723A GB 201816196 A GB201816196 A GB 201816196A GB 2577723 A GB2577723 A GB 2577723A
Authority
GB
United Kingdom
Prior art keywords
compound
overtraining
hydroxybutyrate
subject
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1816196.8A
Other languages
English (en)
Inventor
Clarke Kieran
Hespel Peter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tdeltas Ltd
Original Assignee
Tdeltas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tdeltas Ltd filed Critical Tdeltas Ltd
Priority to GB1816196.8A priority Critical patent/GB2577723A/en
Priority to CA3114889A priority patent/CA3114889A1/en
Priority to AU2019351925A priority patent/AU2019351925B2/en
Priority to PCT/GB2019/052797 priority patent/WO2020070506A1/en
Priority to US17/282,594 priority patent/US12290496B2/en
Priority to GB2105967.0A priority patent/GB2592803B/en
Priority to CN201980065370.4A priority patent/CN112996498B/zh
Priority to EP19787377.1A priority patent/EP3860584B1/en
Priority to KR1020217013546A priority patent/KR102868881B1/ko
Priority to JP2021518512A priority patent/JP7575163B2/ja
Publication of GB2577723A publication Critical patent/GB2577723A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB1816196.8A 2018-10-04 2018-10-04 Compounds for new use Withdrawn GB2577723A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GB1816196.8A GB2577723A (en) 2018-10-04 2018-10-04 Compounds for new use
CA3114889A CA3114889A1 (en) 2018-10-04 2019-10-03 Compounds for use in preventing or treating athlete overtraining
AU2019351925A AU2019351925B2 (en) 2018-10-04 2019-10-03 Compounds for use in preventing or treating athlete overtraining
PCT/GB2019/052797 WO2020070506A1 (en) 2018-10-04 2019-10-03 Compounds for use in preventing or treating athlete overtraining
US17/282,594 US12290496B2 (en) 2018-10-04 2019-10-03 Compounds for use in preventing or treating athlete overtraining
GB2105967.0A GB2592803B (en) 2018-10-04 2019-10-03 Compounds for use in preventing or treating athlete overtraining
CN201980065370.4A CN112996498B (zh) 2018-10-04 2019-10-03 在预防或治疗运动员过度训练中使用的化合物
EP19787377.1A EP3860584B1 (en) 2018-10-04 2019-10-03 Compounds for use in preventing or treating athlete overtraining
KR1020217013546A KR102868881B1 (ko) 2018-10-04 2019-10-03 운동선수의 오버트레이닝을 예방 또는 치료하는데 사용하기 위한 화합물
JP2021518512A JP7575163B2 (ja) 2018-10-04 2019-10-03 アスリートのオーバートレーニングの予防又は処置に用いる化合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1816196.8A GB2577723A (en) 2018-10-04 2018-10-04 Compounds for new use

Publications (1)

Publication Number Publication Date
GB2577723A true GB2577723A (en) 2020-04-08

Family

ID=68242730

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1816196.8A Withdrawn GB2577723A (en) 2018-10-04 2018-10-04 Compounds for new use
GB2105967.0A Active GB2592803B (en) 2018-10-04 2019-10-03 Compounds for use in preventing or treating athlete overtraining

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB2105967.0A Active GB2592803B (en) 2018-10-04 2019-10-03 Compounds for use in preventing or treating athlete overtraining

Country Status (9)

Country Link
US (1) US12290496B2 (https=)
EP (1) EP3860584B1 (https=)
JP (1) JP7575163B2 (https=)
KR (1) KR102868881B1 (https=)
CN (1) CN112996498B (https=)
AU (1) AU2019351925B2 (https=)
CA (1) CA3114889A1 (https=)
GB (2) GB2577723A (https=)
WO (1) WO2020070506A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202100020441A1 (it) 2021-07-30 2023-01-30 Unichem Estense S R L Miscela di un mono-estere e un di-estere, in cui detti mono-estere e di-estere sono esteri dell’acido (R)-3-idrossibutanoico con un polialcol, processo per la preparazione della miscela e relativi usi medici
CN118591523A (zh) * 2021-11-12 2024-09-03 阿萨达股份公司 多元醇衍生的化合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2517088A (en) * 2013-08-07 2015-02-11 Tdeltas Ltd Ketone body and ketone body ester for reducing muscle breakdown
US20150164855A1 (en) * 2012-04-05 2015-06-18 Tdeltas Limited Ketone bodies and ketone body esters for maintaining or improving muscle power output

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090253781A1 (en) 2002-05-24 2009-10-08 Btg International Limited Therapeutic compositions
US6323237B1 (en) 1997-03-17 2001-11-27 Btg International Limited Therapeutic compositions
EP1648952B1 (en) * 2003-06-03 2018-03-07 THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Nutritional supplements and therapeutic compositions comprising (r)-3-hydroxybutyrate derivatives
SE0400355D0 (sv) 2004-02-17 2004-02-17 Synbiotics Ab New synbiotec use
WO2006020137A2 (en) 2004-07-16 2006-02-23 Ketocytonyx Inc. Oligomeric compounds
EP1778615A4 (en) 2004-07-20 2010-01-06 Btg Int Ltd OLIGOMERE KETONE COMPOUNDS
CN100344280C (zh) * 2005-08-01 2007-10-24 清华大学 3－羟基丁酸及其衍生物的新用途
WO2008110034A1 (en) 2007-03-14 2008-09-18 Shantou University 3-hydroxy fatty acid and its derivatives for improving of learning and/or memory of subjects
EP2240017B1 (en) 2008-01-04 2019-03-13 Oxford University Innovation Limited Ketone bodies and ketone body esters as blood lipid lowering agents
US8642654B2 (en) 2009-04-16 2014-02-04 Isis Innovation Limited Hydroxybutyrate ester and medical use thereof
JP5773870B2 (ja) 2008-08-21 2015-09-02 アイシス イノヴェイション リミテッド ヒドロキシ酪酸エステル及びその医学的使用
US8865641B2 (en) 2011-06-16 2014-10-21 The Feinstein Institute For Medical Research Methods of treatment of fatty liver disease by pharmacological activation of cholinergic pathways
GB2515603B (en) 2013-03-14 2015-10-14 Isis Innovation Process for producing (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate
CA2902603C (en) 2013-03-19 2021-03-02 University Of South Florida Compositions and methods for producing elevated and sustained ketosis
US11814664B2 (en) 2013-05-24 2023-11-14 Genomatica, Inc. Microorganisms and methods for producing (3R)-hydroxybutyl (3R)-hydroxybutyrate
US20150283163A1 (en) * 2014-04-04 2015-10-08 Organic Medical Ventures, L.L.C. Muscle treatment composition and method making same
US20180008629A1 (en) 2015-01-29 2018-01-11 Yale University Compositions and Methods for Treating NLRP3 Inflammasome-Related Diseases and Disorders
EA201791982A1 (ru) 2015-03-09 2020-02-17 Интекрин Терапьютикс, Инк. Способы лечения неалкогольной жировой болезни печени и/или липодистрофии
CA3021784A1 (en) 2016-04-19 2017-10-26 Keto Patent Group, Inc. Administration of butyrate, beta-hydroxybutyrate, and related compounds in humans
GB201710229D0 (en) 2017-06-27 2017-08-09 Tdeltas Ltd Compounds for new use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150164855A1 (en) * 2012-04-05 2015-06-18 Tdeltas Limited Ketone bodies and ketone body esters for maintaining or improving muscle power output
GB2517088A (en) * 2013-08-07 2015-02-11 Tdeltas Ltd Ketone body and ketone body ester for reducing muscle breakdown

Also Published As

Publication number Publication date
CA3114889A1 (en) 2020-04-09
JP2022504207A (ja) 2022-01-13
KR20210079304A (ko) 2021-06-29
WO2020070506A1 (en) 2020-04-09
KR102868881B1 (ko) 2025-10-15
GB2592803B (en) 2022-11-09
GB2592803A (en) 2021-09-08
US20210338612A1 (en) 2021-11-04
CN112996498B (zh) 2024-10-29
EP3860584A1 (en) 2021-08-11
JP7575163B2 (ja) 2024-10-29
AU2019351925A1 (en) 2021-04-15
GB202105967D0 (en) 2021-06-09
CN112996498A (zh) 2021-06-18
AU2019351925B2 (en) 2024-12-05
EP3860584B1 (en) 2026-02-18
US12290496B2 (en) 2025-05-06

Similar Documents

Publication Publication Date Title
AU2021240302B2 (en) Ketone body and ketone body ester for reducing muscle breakdown
US20200360517A1 (en) Nutritional composition
AU2013244931B2 (en) Ketone bodies and ketone body esters for maintaining or improving muscle power output
CN111132674A (zh) 治疗方法
AU2019351925B2 (en) Compounds for use in preventing or treating athlete overtraining
HK1225965B (en) Ketone body and ketone body ester for reducing muscle breakdown
HK1206999B (en) Ketone bodies and ketone body esters for maintaining or improving muscle power output

Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)