GB2549298B - Super-resolution imaging - Google Patents

Super-resolution imaging Download PDF

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Publication number
GB2549298B
GB2549298B GB1606268.9A GB201606268A GB2549298B GB 2549298 B GB2549298 B GB 2549298B GB 201606268 A GB201606268 A GB 201606268A GB 2549298 B GB2549298 B GB 2549298B
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GB
United Kingdom
Prior art keywords
super
resolution imaging
resolution
imaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1606268.9A
Other languages
English (en)
Other versions
GB2549298A (en
Inventor
Singh Ahluwalia Balpreet
Schüttpelz Mark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UiT The Arctic University of Norway
Original Assignee
UiT The Arctic University of Norway
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB1606268.9A priority Critical patent/GB2549298B/en
Application filed by UiT The Arctic University of Norway filed Critical UiT The Arctic University of Norway
Priority to EP17718592.3A priority patent/EP3443401B1/en
Priority to PCT/GB2017/051034 priority patent/WO2017178823A1/en
Priority to ES17718592T priority patent/ES2929874T3/es
Priority to KR1020187032632A priority patent/KR102409738B1/ko
Priority to DK17718592.3T priority patent/DK3443401T3/da
Priority to CA3020529A priority patent/CA3020529C/en
Priority to JP2019505295A priority patent/JP6997928B2/ja
Priority to US16/092,724 priority patent/US10983326B2/en
Priority to CN201780028957.9A priority patent/CN109313330B/zh
Priority to AU2017248718A priority patent/AU2017248718B2/en
Publication of GB2549298A publication Critical patent/GB2549298A/en
Application granted granted Critical
Publication of GB2549298B publication Critical patent/GB2549298B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6445—Measuring fluorescence polarisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/56—Optics using evanescent waves, i.e. inhomogeneous waves
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/58—Optics for apodization or superresolution; Optical synthetic aperture systems
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/02—Optical fibres with cladding with or without a coating
    • G02B6/02004—Optical fibres with cladding with or without a coating characterised by the core effective area or mode field radius
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/02—Optical fibres with cladding with or without a coating
    • G02B6/02042—Multicore optical fibres
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
    • G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
    • G02B6/122—Basic optical elements, e.g. light-guiding paths
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T3/00—Geometric image transformations in the plane of the image
    • G06T3/40—Scaling of whole images or parts thereof, e.g. expanding or contracting
    • G06T3/4053—Scaling of whole images or parts thereof, e.g. expanding or contracting based on super-resolution, i.e. the output image resolution being higher than the sensor resolution
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
    • G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
    • G02B2006/12083—Constructional arrangements
    • G02B2006/12102—Lens

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Multimedia (AREA)
  • Health & Medical Sciences (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Theoretical Computer Science (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
GB1606268.9A 2016-04-12 2016-04-12 Super-resolution imaging Active GB2549298B (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
GB1606268.9A GB2549298B (en) 2016-04-12 2016-04-12 Super-resolution imaging
US16/092,724 US10983326B2 (en) 2016-04-12 2017-04-12 Super-resolution imaging
ES17718592T ES2929874T3 (es) 2016-04-12 2017-04-12 Formación de imágenes de superresolución
KR1020187032632A KR102409738B1 (ko) 2016-04-12 2017-04-12 슈퍼-해상도 이미징
DK17718592.3T DK3443401T3 (da) 2016-04-12 2017-04-12 Superopløsningsafbildning
CA3020529A CA3020529C (en) 2016-04-12 2017-04-12 Super-resolution imaging
EP17718592.3A EP3443401B1 (en) 2016-04-12 2017-04-12 Super-resolution imaging
PCT/GB2017/051034 WO2017178823A1 (en) 2016-04-12 2017-04-12 Super-resolution imaging
CN201780028957.9A CN109313330B (zh) 2016-04-12 2017-04-12 执行对样本的超分辨率荧光显微技术成像的装置和方法
AU2017248718A AU2017248718B2 (en) 2016-04-12 2017-04-12 Super-resolution imaging
JP2019505295A JP6997928B2 (ja) 2016-04-12 2017-04-12 超解像撮像

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1606268.9A GB2549298B (en) 2016-04-12 2016-04-12 Super-resolution imaging

Publications (2)

Publication Number Publication Date
GB2549298A GB2549298A (en) 2017-10-18
GB2549298B true GB2549298B (en) 2022-02-02

Family

ID=58579213

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1606268.9A Active GB2549298B (en) 2016-04-12 2016-04-12 Super-resolution imaging

Country Status (11)

Country Link
US (1) US10983326B2 (enExample)
EP (1) EP3443401B1 (enExample)
JP (1) JP6997928B2 (enExample)
KR (1) KR102409738B1 (enExample)
CN (1) CN109313330B (enExample)
AU (1) AU2017248718B2 (enExample)
CA (1) CA3020529C (enExample)
DK (1) DK3443401T3 (enExample)
ES (1) ES2929874T3 (enExample)
GB (1) GB2549298B (enExample)
WO (1) WO2017178823A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3839483B1 (en) * 2019-12-19 2023-07-26 Imec VZW An illuminator, an imaging apparatus and a system
KR20220138386A (ko) * 2020-01-14 2022-10-12 퀀텀-에스아이 인코포레이티드 도파관 여기 균일성
CN111722392B (zh) * 2020-07-22 2021-06-08 南京大学 一种基于超构透镜阵列的大视场集成显微成像装置
KR102654655B1 (ko) 2020-10-20 2024-04-05 한양대학교 산학협력단 초고해상도 형광 현미경 이미징 방법 및 초고해상도 형광 현미경 이미징 장치
KR102619825B1 (ko) 2020-10-20 2024-01-03 한양대학교 산학협력단 초고해상도 형광 현미경용 이미징 버퍼 용액 및 이를 이용한 초고해상도 형광 현미경 이미징 방법
CN113031243B (zh) * 2021-03-26 2021-08-31 杭州辰景光电科技有限公司 一种基于波导片的反射式片上数字全息显微装置
DE102021131952A1 (de) * 2021-12-03 2023-06-07 Interherence GmbH Optisches Modul
US12536611B2 (en) * 2021-12-08 2026-01-27 Bar Ilan University Method and system for super-resolved imaging
EP4220269A1 (en) * 2022-01-27 2023-08-02 Abbelight Light imaging device
KR102742598B1 (ko) * 2022-02-10 2024-12-16 한양대학교 산학협력단 형광현미경 또는 초고해상도 형광현미경을 이용한 용매의 수소 결합 센싱 방법
CN116297377B (zh) * 2023-05-22 2023-07-28 深圳高性能医疗器械国家研究院有限公司 单分子荧光检测芯片及其制备方法、单分子荧光检测仪

Citations (5)

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DE4426968A1 (de) * 1994-07-29 1996-02-01 Bosch Gmbh Robert Lichtleiter, vorzugsweise zur seitlichen Beleuchtung eines Objektes
US20120092477A1 (en) * 2010-10-18 2012-04-19 Olympus America Inc. Wide field microscopic imaging system and method
CN102928384A (zh) * 2012-10-24 2013-02-13 浙江大学 基于微波导的超分辨显微成像方法和装置
EP2801854A1 (en) * 2013-05-10 2014-11-12 Ruprecht-Karls-Universität Heidelberg Method and apparatus for combination of localization microscopy and structured illumination microscopy
WO2016006006A1 (en) * 2014-07-09 2016-01-14 Ntp Nano Tech Projects S.R.L. Laser optical coupling for nanoparticles detection

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WO2009115108A1 (en) * 2008-03-19 2009-09-24 Ruprecht-Karls-Universität Heidelberg A method and an apparatus for localization of single dye molecules in the fluorescent microscopy
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DE4426968A1 (de) * 1994-07-29 1996-02-01 Bosch Gmbh Robert Lichtleiter, vorzugsweise zur seitlichen Beleuchtung eines Objektes
US20120092477A1 (en) * 2010-10-18 2012-04-19 Olympus America Inc. Wide field microscopic imaging system and method
CN102928384A (zh) * 2012-10-24 2013-02-13 浙江大学 基于微波导的超分辨显微成像方法和装置
EP2801854A1 (en) * 2013-05-10 2014-11-12 Ruprecht-Karls-Universität Heidelberg Method and apparatus for combination of localization microscopy and structured illumination microscopy
WO2016006006A1 (en) * 2014-07-09 2016-01-14 Ntp Nano Tech Projects S.R.L. Laser optical coupling for nanoparticles detection

Also Published As

Publication number Publication date
JP2019516140A (ja) 2019-06-13
CN109313330B (zh) 2021-06-15
JP6997928B2 (ja) 2022-01-18
US20190129161A1 (en) 2019-05-02
EP3443401B1 (en) 2022-07-20
AU2017248718B2 (en) 2021-07-15
WO2017178823A1 (en) 2017-10-19
US10983326B2 (en) 2021-04-20
AU2017248718A1 (en) 2018-10-25
KR20180130567A (ko) 2018-12-07
EP3443401A1 (en) 2019-02-20
CA3020529C (en) 2023-10-17
CA3020529A1 (en) 2017-10-19
KR102409738B1 (ko) 2022-06-15
DK3443401T3 (da) 2022-10-24
CN109313330A (zh) 2019-02-05
GB2549298A (en) 2017-10-18
ES2929874T3 (es) 2022-12-02

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