GB2415437A - Differentiation of human embryonic stem cells to cardiomyocytes - Google Patents

Differentiation of human embryonic stem cells to cardiomyocytes Download PDF

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Publication number
GB2415437A
GB2415437A GB0520673A GB0520673A GB2415437A GB 2415437 A GB2415437 A GB 2415437A GB 0520673 A GB0520673 A GB 0520673A GB 0520673 A GB0520673 A GB 0520673A GB 2415437 A GB2415437 A GB 2415437A
Authority
GB
United Kingdom
Prior art keywords
differentiation
cardiomyocytes
stem cells
embryonic stem
human embryonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0520673A
Other languages
English (en)
Other versions
GB0520673D0 (en
Inventor
Christine Lindsay Mummery
Petrus Adrianus Fre Doevendans
Leon Gerardus Joseph Tertoolen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Es Cell International Pte Ltd
Netherlands Instituut Voor Ontwikkelingsbiologie
NETHERLANDS INST VOOR ONTWIKKE
ES Cell International Pte Ltd
Original Assignee
Es Cell International Pte Ltd
Netherlands Instituut Voor Ontwikkelingsbiologie
NETHERLANDS INST VOOR ONTWIKKE
ES Cell International Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Es Cell International Pte Ltd, Netherlands Instituut Voor Ontwikkelingsbiologie, NETHERLANDS INST VOOR ONTWIKKE, ES Cell International Pte Ltd filed Critical Es Cell International Pte Ltd
Publication of GB0520673D0 publication Critical patent/GB0520673D0/en
Publication of GB2415437A publication Critical patent/GB2415437A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
GB0520673A 2003-03-11 2004-03-11 Differentiation of human embryonic stem cells to cardiomyocytes Withdrawn GB2415437A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2003901099A AU2003901099A0 (en) 2003-03-11 2003-03-11 Methods of inducing differentiation of stem cells
PCT/AU2004/000302 WO2004081205A1 (en) 2003-03-11 2004-03-11 Differentiation of human embryonic stem cells to cardiomyocytes

Publications (2)

Publication Number Publication Date
GB0520673D0 GB0520673D0 (en) 2005-11-16
GB2415437A true GB2415437A (en) 2005-12-28

Family

ID=31500143

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0520673A Withdrawn GB2415437A (en) 2003-03-11 2004-03-11 Differentiation of human embryonic stem cells to cardiomyocytes

Country Status (7)

Country Link
US (1) US20070161107A1 (https=)
EP (1) EP1608740A4 (https=)
JP (1) JP2006523091A (https=)
AU (1) AU2003901099A0 (https=)
CA (1) CA2518508A1 (https=)
GB (1) GB2415437A (https=)
WO (1) WO2004081205A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2429718B (en) * 2004-06-01 2008-12-17 Es Cell Int Pte Ltd Improved cardiomyocyte differentiation

Families Citing this family (35)

* Cited by examiner, † Cited by third party
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US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
WO2003006950A2 (en) 2001-07-12 2003-01-23 Geron Corporation Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
CA2611809C (en) 2005-06-22 2018-06-19 Geron Corporation Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells
US20090227032A1 (en) 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
BRPI0619794B8 (pt) 2005-12-13 2022-06-14 Univ Kyoto Uso de um fator de reprogramação, agente para a preparação de uma célula-tronco pluripotente induzida a partir de uma célula somática e métodos para preparar uma célula- tronco pluripotente induzida método e para preparar uma célula somática e uso de células-tronco pluripotentes induzidas
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
US8129187B2 (en) 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
WO2008073331A2 (en) * 2006-12-07 2008-06-19 Teva Pharmaceutical Industries Ltd. Method of generation and expansion of tissue-progenitor cells and mature tissue cells from intact bone marrow or intact umbilical cord tissue
US20080300642A1 (en) * 2007-05-30 2008-12-04 Japan As Represented By President Of National Cardiovascular Center Regeneration treatment apparatus, operating method thereof, and regeneration treatment method
US9213999B2 (en) 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
WO2009036220A2 (en) * 2007-09-12 2009-03-19 The Regents Of The University Of California Compositions and methods for improving the functional efficacy of stem cell-derived cardiomyocytes
JP5558097B2 (ja) 2007-12-10 2014-07-23 国立大学法人京都大学 効率的な核初期化方法
US9683232B2 (en) 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
CN101939418A (zh) 2008-01-30 2011-01-05 杰龙公司 用于培养干细胞衍生的心肌细胞的合成表面
SG188904A1 (en) 2008-03-17 2013-04-30 Scripps Research Inst Combined chemical and genetic approaches for generation of induced pluripotent stem cells
SG10201400329YA (en) 2008-05-02 2014-05-29 Univ Kyoto Method of nuclear reprogramming
US20110207215A1 (en) * 2008-10-24 2011-08-25 Kuraray Co., Ltd. Cell storage method and cell transport method
BRPI0922572A2 (pt) 2008-12-17 2019-09-24 Scripps Research Inst método para cultivar células pluripotentes, cultura de células de mamífero pluripotentes, meio de cultura de célula, célula animal pluripotente isolada, e, método para aumentar a pluripotência de uma célula de mamífero.
JPWO2010134606A1 (ja) 2009-05-22 2012-11-12 学校法人東京女子医科大学 胚性幹細胞或いは人工多能性幹細胞の分化誘導方法
AU2010306627B2 (en) 2009-10-16 2014-07-17 The Scripps Research Institute Induction of pluripotent cells
CA2800498C (en) 2010-03-31 2021-11-16 The Scripps Research Institute Reprogramming cells
US9273286B2 (en) 2010-06-13 2016-03-01 Institute Of Biophysics, Chinese Academy Of Sciences Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof
EP3399026B1 (en) 2010-06-14 2024-06-26 The Scripps Research Institute Reprogramming of cells to a new fate
WO2012087965A2 (en) 2010-12-22 2012-06-28 Fate Therapauetics, Inc. Cell culture platform for single cell sorting and enhanced reprogramming of ipscs
WO2013033213A1 (en) 2011-08-30 2013-03-07 The J. David Gladstone Institutes Methods for generating cardiomyocytes
CN104508121B (zh) 2012-07-23 2018-01-19 中国科学院生物物理研究所 体外诱导多能干细胞分化为心室肌细胞的方法
EP2948542A4 (en) 2013-01-23 2016-07-13 Ronald Li MANIPULATED PHYSICAL ORIENTATION OF CARDIOMYOCYTES FROM STEM CELLS
JPWO2015025958A1 (ja) * 2013-08-23 2017-03-02 国立大学法人大阪大学 ペースメーカー組織片の製造方法
US10087436B2 (en) 2014-02-06 2018-10-02 The Regents Of The University Of California Electrophysiologically mature cardiomyocytes and methods for making same
SG11201606934SA (en) 2014-03-04 2016-09-29 Fate Therapeutics Inc Improved reprogramming methods and cell culture platforms
SG10202111851YA (en) 2015-10-16 2021-12-30 Fate Therapeutics Inc Platform for the Induction & Maintenance of Ground State Pluripotency
CN113662985B (zh) 2021-09-07 2022-06-24 北京中医药大学 具有促进干细胞定向分化为心肌细胞作用的中药组合物、中药有效组分组合物及其应用
WO2024162286A1 (ja) 2023-01-31 2024-08-08 富士フイルム株式会社 薬剤の評価方法、試薬およびキット

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003010303A1 (en) * 2001-07-24 2003-02-06 Es Cell International Pte Ltd Methods of inducing differentiation of stem cells
CA2493588C (en) * 2002-07-26 2012-09-11 Wisconsin Alumni Research Foundation Functional cardiomyocytes from human embryonic stem cells
WO2005054448A1 (en) * 2003-12-04 2005-06-16 Guhathakurta Dr Soma A novel process and method for deriving cardiomyocyte precursors from bone-marrow stem cells

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Circ. Res., Vol.91, 2002, Chunhui, X. et al., "Characterization and enrichment...", pp.501-508 *
Circulation, Vol.107, 2003, Mummery, C. et al., "Differentiation of human embryonic...", pp.2733-2740 *
Curr. Biol., Vol.11, 2001, Eiges, R. et al., "Establishment of human embryonic...", pp.514-518 *
Dev. Dyn., Vol.210, 1997, Arai, A. et al., "Murine cardiac progenitor...", pp.344-353 *
Heart Failure Rev., Vol.8, 2003, Kehat, I. et al., "Human embryonic stem cells...", pp.229-236 *
Herz, Vol.27, 2002, Sachinidis, A. et al., "Generation of cardiomyocytes...", pp.589-597 *
J. Anat., Vol.200, 2002, Mummery, C. et al., "Cardiomyocyte differentiation...", pp.233-242 *
Reprod. BioMed. Online, Vol.4, 2002, Trounson, A., "Human embryonic stem cells...", pp.58-63 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2429718B (en) * 2004-06-01 2008-12-17 Es Cell Int Pte Ltd Improved cardiomyocyte differentiation

Also Published As

Publication number Publication date
JP2006523091A (ja) 2006-10-12
GB0520673D0 (en) 2005-11-16
WO2004081205A8 (en) 2004-10-28
WO2004081205A1 (en) 2004-09-23
CA2518508A1 (en) 2004-09-23
US20070161107A1 (en) 2007-07-12
EP1608740A4 (en) 2007-05-09
AU2003901099A0 (en) 2003-03-27
EP1608740A1 (en) 2005-12-28

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