GB2359078A - Pharmaceutically active pyrimidine derivatives - Google Patents
Pharmaceutically active pyrimidine derivatives Download PDFInfo
- Publication number
- GB2359078A GB2359078A GB0003019A GB0003019A GB2359078A GB 2359078 A GB2359078 A GB 2359078A GB 0003019 A GB0003019 A GB 0003019A GB 0003019 A GB0003019 A GB 0003019A GB 2359078 A GB2359078 A GB 2359078A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- pharmaceutically acceptable
- optionally substituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
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- 125000005843 halogen group Chemical group 0.000 claims description 18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Surgery (AREA)
- AIDS & HIV (AREA)
- Psychology (AREA)
- Tropical Medicine & Parasitology (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0003019A GB2359078A (en) | 2000-02-11 | 2000-02-11 | Pharmaceutically active pyrimidine derivatives |
| US10/203,584 US6958344B2 (en) | 2000-02-11 | 2001-02-07 | Pyrimidine compounds and their use as modulators of chemokine receptor activity |
| EP01902950A EP1265899A1 (en) | 2000-02-11 | 2001-02-07 | Pyrimidine compounds and their use as modulators of chemokine receptor activity |
| AU2001230704A AU2001230704A1 (en) | 2000-02-11 | 2001-02-07 | Pyrimidine compounds and their use as modulators of chemokine receptor activity |
| PCT/SE2001/000245 WO2001058902A1 (en) | 2000-02-11 | 2001-02-07 | Pyrimidine compounds and their use as modulators of chemokine receptor activity |
| JP2001558051A JP2003522189A (ja) | 2000-02-11 | 2001-02-07 | ケモカインレセプター活性のモジュレーターとしてのピリミジン化合物およびそれらの使用 |
| US11/036,682 US20050234077A1 (en) | 2000-02-11 | 2005-01-14 | Pyrimidine compounds and their use as modulators of chemokine receptor activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0003019A GB2359078A (en) | 2000-02-11 | 2000-02-11 | Pharmaceutically active pyrimidine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB0003019D0 GB0003019D0 (en) | 2000-03-29 |
| GB2359078A true GB2359078A (en) | 2001-08-15 |
Family
ID=9885284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0003019A Withdrawn GB2359078A (en) | 2000-02-11 | 2000-02-11 | Pharmaceutically active pyrimidine derivatives |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6958344B2 (https=) |
| EP (1) | EP1265899A1 (https=) |
| JP (1) | JP2003522189A (https=) |
| AU (1) | AU2001230704A1 (https=) |
| GB (1) | GB2359078A (https=) |
| WO (1) | WO2001058902A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9903544D0 (sv) | 1999-10-01 | 1999-10-01 | Astra Pharma Prod | Novel compounds |
| GB2359081A (en) | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active thiazolopyrimidines |
| DE60101372T2 (de) * | 2000-02-11 | 2004-10-14 | Astrazeneca Ab | Pyrimidinverbindungen und ihre verwendung als modulatoren der chemokin-rezeptor-aktivität |
| GB2359551A (en) * | 2000-02-23 | 2001-08-29 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
| SE0003828D0 (sv) * | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Novel compounds |
| SE0101322D0 (sv) | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | Novel compounds |
| SE0102716D0 (sv) * | 2001-08-14 | 2001-08-14 | Astrazeneca Ab | Novel compounds |
| EP2399903A1 (en) * | 2002-05-24 | 2011-12-28 | Millennium Pharmaceuticals, Inc. | Ccr9 inhibitors and methods of use thereof |
| GB0217431D0 (en) | 2002-07-27 | 2002-09-04 | Astrazeneca Ab | Novel compounds |
| US7482355B2 (en) | 2002-08-24 | 2009-01-27 | Astrazeneca Ab | Pyrimidine derivatives as modulators of chemokine receptor activity |
| GB0221828D0 (en) * | 2002-09-20 | 2002-10-30 | Astrazeneca Ab | Novel compound |
| GB0221829D0 (en) * | 2002-09-20 | 2002-10-30 | Astrazeneca Ab | Novel compound |
| GB0328243D0 (en) * | 2003-12-05 | 2004-01-07 | Astrazeneca Ab | Methods |
| GB0401269D0 (en) * | 2004-01-21 | 2004-02-25 | Astrazeneca Ab | Compounds |
| ES2294400T3 (es) * | 2004-06-29 | 2008-04-01 | Grunenthal Gmbh | Nuevos analogos de notrobenciltioinosina. |
| KR101280095B1 (ko) | 2004-08-28 | 2013-09-09 | 아스트라제네카 아베 | 케모킨 수용체 조절제로서의 피리미딘 술폰아미드 유도체 |
| WO2009042139A1 (en) * | 2007-09-25 | 2009-04-02 | Actimis Pharmaceuticals, Inc. | 2-s-benzyl substituted pyrimidines as crth2 antagonists |
| ATE547407T1 (de) | 2007-09-25 | 2012-03-15 | Actimis Pharmaceuticals Inc | Alkylthiopyrimidine als crth2-antagonisten |
| AU2009322836B2 (en) * | 2008-11-25 | 2013-04-04 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| MX2013002895A (es) * | 2010-09-14 | 2013-06-05 | Inst Biochemii I Biofizyki Pan | Compuestos como moduladores de una proteina cftr mutante y su uso para tratar enfermedades asociadas con las deficiencias de la proteina cftr. |
| CN109020882A (zh) * | 2018-08-09 | 2018-12-18 | 杭州华东医药集团浙江华义制药有限公司 | 3,5-二氯-2-氰基吡啶的合成方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999028321A1 (en) * | 1997-11-28 | 1999-06-10 | Sumitomo Pharmaceuticals Company, Limited | Novel heterocyclic compounds |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3318900A (en) | 1964-05-06 | 1967-05-09 | Janssen Pharmaceutica Nv | Derivatives of benzimidazolinyl piperidine |
| DE2331223C2 (de) | 1972-06-19 | 1984-11-22 | Kohjin Co., Ltd., Tokio / Tokyo | S-substituierte-2-Thioadenosine, deren 5'-Monophosphate, Verfahren zu deren Herstellung und Arzneimittel, welche diese enthalten |
| JPS5188994A (en) * | 1975-02-04 | 1976-08-04 | Shinkijichikan 88 aminoadeninjudotainoseizoho | |
| EG12406A (en) | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
| FR2421899A1 (fr) | 1978-01-16 | 1979-11-02 | Roussel Uclaf | Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits |
| US4410528A (en) | 1980-05-16 | 1983-10-18 | Kyowa Hakko Kogyo Co., Ltd. | Hypotensive piperidine derivatives |
| CA1338012C (en) | 1987-04-27 | 1996-01-30 | John Michael Mccall | Pharmaceutically active amines |
| FR2659656B1 (fr) | 1990-03-15 | 1994-09-09 | Sanofi Sa | Derives de pyrimidinedione-2,4 et medicaments les contenant. |
| DE4119767A1 (de) | 1991-06-15 | 1992-12-17 | Dresden Arzneimittel | Verfahren zur herstellung von (pyrimid-2-yl-thio- bzw. seleno)-essigsaeurederivaten |
| US5521197A (en) | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
| DE69628804T2 (de) * | 1995-12-08 | 2003-12-18 | Pfizer Inc., New York | Substitutierte heterozyclische Derivate als CRF Antagonisten |
| WO1997040035A1 (en) | 1996-04-19 | 1997-10-30 | Neurosearch A/S | 1-(4-piperidyl)-benzimidazoles having neurotrophic activity |
| IL127566A0 (en) | 1996-08-28 | 1999-10-28 | Pfizer | Substituted 6,5-hetero- bicyclic derivatives |
| AU5522498A (en) | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Substituted aryl piperazines as modulators of chemokine receptor activity |
| WO1999004794A1 (en) | 1997-07-25 | 1999-02-04 | Merck & Co., Inc. | Cyclic amine modulators of chemokine receptor activity |
| AR013669A1 (es) | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
| EA200000683A1 (ru) | 1998-01-19 | 2000-12-25 | Пфайзер Инк. | Производные ряда 4-(2-кето-1-бензимидазолинил)пиперидина в качестве агонистов orl1-рецептора |
| CN1166665C (zh) | 1998-03-19 | 2004-09-15 | 日本农药株式会社 | 芳基哌啶衍生物及其用途 |
| WO1999051608A1 (en) * | 1998-04-03 | 1999-10-14 | Du Pont Pharmaceuticals Company | THIAZOLO[4,5-d]PYRIMIDINES AND PYRIDINES AS CORTICOTROPIN RELEASING FACTOR (CRF) ANTAGONISTS |
| MA26659A1 (fr) | 1998-08-06 | 2004-12-20 | Pfizer | Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation. |
| SE9802729D0 (sv) * | 1998-08-13 | 1998-08-13 | Astra Pharma Prod | Novel Compounds |
| PE20001420A1 (es) | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
| ES2229803T3 (es) | 1998-12-28 | 2005-04-16 | 4 Aza Bioscience Nv | Efectos inmunosupresivos de derivados de pteridina. |
| CA2361561A1 (en) | 1999-02-02 | 2000-08-10 | K.U. Leuven Research & Development | Immunosurpressive effects of pteridine derivatives |
| US6248755B1 (en) | 1999-04-06 | 2001-06-19 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| AU5600100A (en) | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| US6340681B1 (en) | 1999-07-16 | 2002-01-22 | Pfizer Inc | 2-benzimidazolylamine compounds as ORL-1-receptor agonists |
| EP1409487A1 (en) | 1999-09-15 | 2004-04-21 | Warner-Lambert Company Llc | Pteridinones as kinase inhibitors |
| SE9903544D0 (sv) | 1999-10-01 | 1999-10-01 | Astra Pharma Prod | Novel compounds |
| AR025884A1 (es) | 1999-10-01 | 2002-12-18 | Takeda Pharmaceutical | Compuestos de amina ciclica, su produccion y su uso |
| DE60023100T2 (de) | 2000-01-05 | 2006-07-06 | Pfizer Inc. | Benzimidazol-Verbindungen zur Verwendung als ORL1-Rezeptor-Antagonisten |
| DE60101372T2 (de) * | 2000-02-11 | 2004-10-14 | Astrazeneca Ab | Pyrimidinverbindungen und ihre verwendung als modulatoren der chemokin-rezeptor-aktivität |
| GB2359081A (en) | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active thiazolopyrimidines |
| GB2359079A (en) * | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
| GB2359551A (en) | 2000-02-23 | 2001-08-29 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
| GB0005642D0 (en) * | 2000-03-10 | 2000-05-03 | Astrazeneca Uk Ltd | Chemical compounds |
| SE0101322D0 (sv) * | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | Novel compounds |
| SE0102716D0 (sv) | 2001-08-14 | 2001-08-14 | Astrazeneca Ab | Novel compounds |
-
2000
- 2000-02-11 GB GB0003019A patent/GB2359078A/en not_active Withdrawn
-
2001
- 2001-02-07 JP JP2001558051A patent/JP2003522189A/ja active Pending
- 2001-02-07 EP EP01902950A patent/EP1265899A1/en not_active Withdrawn
- 2001-02-07 US US10/203,584 patent/US6958344B2/en not_active Expired - Fee Related
- 2001-02-07 WO PCT/SE2001/000245 patent/WO2001058902A1/en not_active Ceased
- 2001-02-07 AU AU2001230704A patent/AU2001230704A1/en not_active Abandoned
-
2005
- 2005-01-14 US US11/036,682 patent/US20050234077A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999028321A1 (en) * | 1997-11-28 | 1999-06-10 | Sumitomo Pharmaceuticals Company, Limited | Novel heterocyclic compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| US6958344B2 (en) | 2005-10-25 |
| US20030040523A1 (en) | 2003-02-27 |
| US20050234077A1 (en) | 2005-10-20 |
| JP2003522189A (ja) | 2003-07-22 |
| GB0003019D0 (en) | 2000-03-29 |
| AU2001230704A1 (en) | 2001-08-20 |
| WO2001058902A1 (en) | 2001-08-16 |
| EP1265899A1 (en) | 2002-12-18 |
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Legal Events
| Date | Code | Title | Description |
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| COOA | Change in applicant's name or ownership of the application | ||
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |