GB2351151B - Compound Screening Method in Nematode Worms - Google Patents

Compound Screening Method in Nematode Worms

Info

Publication number
GB2351151B
GB2351151B GB0009358A GB0009358A GB2351151B GB 2351151 B GB2351151 B GB 2351151B GB 0009358 A GB0009358 A GB 0009358A GB 0009358 A GB0009358 A GB 0009358A GB 2351151 B GB2351151 B GB 2351151B
Authority
GB
United Kingdom
Prior art keywords
screening method
compound screening
nematode worms
nematode
worms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0009358A
Other languages
English (en)
Other versions
GB2351151A (en
GB0009358D0 (en
Inventor
Philippe Verwaerde
Christ Platteeuw
Gwladys Cuvillier
Thierry Bogaert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Devgen NV
Original Assignee
Devgen NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9908670.4A external-priority patent/GB9908670D0/en
Priority to GB0111787A priority Critical patent/GB2359361B/en
Priority to GB0111713A priority patent/GB2359359B/en
Priority to GB0111712A priority patent/GB2359358B/en
Priority to GB0111778A priority patent/GB2359627B/en
Priority to GB0111714A priority patent/GB2359626B/en
Application filed by Devgen NV filed Critical Devgen NV
Priority to GB0111783A priority patent/GB2359360B/en
Publication of GB0009358D0 publication Critical patent/GB0009358D0/en
Publication of GB2351151A publication Critical patent/GB2351151A/en
Publication of GB2351151B publication Critical patent/GB2351151B/en
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/033Rearing or breeding invertebrates; New breeds of invertebrates
    • A01K67/0333Genetically modified invertebrates, e.g. transgenic, polyploid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082Supracellular entities, e.g. tissue, organisms
    • G01N33/5085Supracellular entities, e.g. tissue, organisms of invertebrates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406Neurotransmitters
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43526Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms
    • G01N2333/4353Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes
    • G01N2333/43534Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes from Caenorhabditis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4709Amyloid plaque core protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4712Muscle proteins, e.g. myosin, actin, protein

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Environmental Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
GB0009358A 1999-04-15 2000-04-14 Compound Screening Method in Nematode Worms Expired - Fee Related GB2351151B (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB0111713A GB2359359B (en) 1999-04-15 2000-04-14 Compound screening method
GB0111712A GB2359358B (en) 1999-04-15 2000-04-14 Compound screening method
GB0111778A GB2359627B (en) 1999-04-15 2000-04-14 Compound screening method
GB0111714A GB2359626B (en) 1999-04-15 2000-04-14 Compound screening method
GB0111787A GB2359361B (en) 1999-04-15 2000-04-14 Compound screening method
GB0111783A GB2359360B (en) 1999-04-15 2000-04-14 Compound screening method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12959699P 1999-04-15 1999-04-15
GBGB9908670.4A GB9908670D0 (en) 1999-04-15 1999-04-15 Compound screening method

Publications (3)

Publication Number Publication Date
GB0009358D0 GB0009358D0 (en) 2000-05-31
GB2351151A GB2351151A (en) 2000-12-20
GB2351151B true GB2351151B (en) 2001-07-25

Family

ID=26315417

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0009358A Expired - Fee Related GB2351151B (en) 1999-04-15 2000-04-14 Compound Screening Method in Nematode Worms

Country Status (10)

Country Link
EP (1) EP1175506A2 (ja)
JP (1) JP2002542466A (ja)
AU (1) AU780574B2 (ja)
CA (1) CA2365707A1 (ja)
GB (1) GB2351151B (ja)
HK (1) HK1030047A1 (ja)
HU (1) HUP0201142A2 (ja)
MX (1) MXPA01010175A (ja)
PL (1) PL351432A1 (ja)
WO (1) WO2000063427A2 (ja)

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WO2000011449A1 (en) 1998-08-21 2000-03-02 Union Biometrica, Inc. Instrument for selecting and depositing multicellular organisms and other large objects
AU5299200A (en) * 1999-05-27 2000-12-18 Pharmacia & Upjohn Company A nematode drug screen for modulators of mammalian disorders
WO2001070944A2 (de) * 2000-03-22 2001-09-27 Aventis Pharma Deutschland Gmbh Nematoden als modellorganismen zur untersuchung neurodegenerativer erkrankungen und insbesonder der parkinsonschen erkrankung, verwendungen und verfahren zum auffinden von substanzen und genen, die bei der behandlung solcher erfrankungen eingesetz werden können, sowie identifizierung eines nematodengens.
US7083947B2 (en) 2000-05-19 2006-08-01 Devgen Nv Assay techniques using nematode worms
GB0012229D0 (en) 2000-05-19 2000-07-12 Devgen Nv Lipid uptake assays
US20030138803A1 (en) * 2001-07-27 2003-07-24 Brooksbank Robert Alan Identification and use of molecules implicated in pain
US20040058326A1 (en) * 2001-07-27 2004-03-25 Brooksbank Robert Alan Identification and use of molecules implicated in pain
US20030134301A1 (en) * 2001-07-27 2003-07-17 Brooksbank Robert Alan Identification and use of molecules implicated in pain
AU2002343512B2 (en) 2001-10-15 2007-12-06 E.I. Du Pont De Nemours And Company Iminobenzoxazines, iminobenzthiazines and iminoquinazolines for controlling invertebrate pests
US20080038198A1 (en) * 2004-01-05 2008-02-14 Mitsubishi Pharma Corporation Method Of Screening Molecule Associated With Psychiatric Disorder
KR100848790B1 (ko) * 2006-12-27 2008-07-30 연세대학교 산학협력단 소나무 재선충, 다이플로스캡터 및 예쁜 꼬마선충에 대한살선충제의 고속 스크리닝 방법
WO2011017319A1 (en) 2009-08-03 2011-02-10 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods of treating disorders associated with protein polymerization
US9072772B2 (en) 2009-11-05 2015-07-07 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of treating disorders associated with protein aggregation
US8809617B2 (en) * 2009-11-05 2014-08-19 The University of Pittsburgh—Of the Commonwealth System of Higher Education Automated high-content live animal drug screening using C. elegans
KR101764832B1 (ko) * 2015-04-27 2017-08-03 서울시립대학교 산학협력단 산화 스트레스 유발 물질 스크리닝용 bli-3 유전자 기능이 저하된 C. elegans 및 이를 이용한 산화 스트레스 유발 물질 스크리닝 방법
CN111066735A (zh) * 2019-12-24 2020-04-28 深圳市铁汉生态环境股份有限公司 一种用于昆虫取食量测量的饲养装置
CN112379064B (zh) * 2020-11-18 2021-08-13 浙江省林业科学研究院 一种高通量筛选松材线虫抑制剂的方法
KR102706633B1 (ko) * 2023-01-05 2024-09-12 한림대학교 산학협력단 신경독성이 유도된 예쁜꼬마선충 동물모델 및 그 제조방법

Citations (5)

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WO1990009096A2 (en) * 1989-02-03 1990-08-23 Cambridge Neuroscience Research, Inc. Method of screening and classifying compounds
WO1996038555A2 (en) * 1995-05-31 1996-12-05 Thierry Bogaert Unc-53 from c. elegans and its uses in testing compounds involved in the control fo cell behaviour and pharmaceutical compositions
WO1998053856A1 (en) * 1997-05-29 1998-12-03 The General Hospital Corporation Methods for the detection, treatment, and prevention of neurodegeneration
WO1999002652A1 (en) * 1997-07-11 1999-01-21 The General Hospital Corporation Transgenic nematode model of triplet repeat neurological diseases
WO2000040711A2 (en) * 1999-01-06 2000-07-13 California Institute Of Technology Polycystic kidney disease gene homologs required for male mating behavior in nematodes and assays based thereon

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US6087153A (en) * 1997-07-24 2000-07-11 The Trustees Of Columbia University In The City Of New York Sel-10 and uses thereof
GB9826890D0 (en) * 1998-12-07 1999-01-27 Devgen Nv Method for screening compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009096A2 (en) * 1989-02-03 1990-08-23 Cambridge Neuroscience Research, Inc. Method of screening and classifying compounds
WO1996038555A2 (en) * 1995-05-31 1996-12-05 Thierry Bogaert Unc-53 from c. elegans and its uses in testing compounds involved in the control fo cell behaviour and pharmaceutical compositions
WO1998053856A1 (en) * 1997-05-29 1998-12-03 The General Hospital Corporation Methods for the detection, treatment, and prevention of neurodegeneration
WO1999002652A1 (en) * 1997-07-11 1999-01-21 The General Hospital Corporation Transgenic nematode model of triplet repeat neurological diseases
WO2000040711A2 (en) * 1999-01-06 2000-07-13 California Institute Of Technology Polycystic kidney disease gene homologs required for male mating behavior in nematodes and assays based thereon

Also Published As

Publication number Publication date
WO2000063427A2 (en) 2000-10-26
GB2351151A (en) 2000-12-20
WO2000063427A3 (en) 2001-12-06
HUP0201142A2 (en) 2002-08-28
JP2002542466A (ja) 2002-12-10
AU4137600A (en) 2000-11-02
AU780574B2 (en) 2005-04-07
MXPA01010175A (es) 2002-04-09
CA2365707A1 (en) 2000-10-26
EP1175506A2 (en) 2002-01-30
GB0009358D0 (en) 2000-05-31
HK1030047A1 (en) 2001-04-20
PL351432A1 (en) 2003-04-22

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PCNP Patent ceased through non-payment of renewal fee

Effective date: 20090414