GB2351151B - Compound Screening Method in Nematode Worms - Google Patents
Compound Screening Method in Nematode WormsInfo
- Publication number
- GB2351151B GB2351151B GB0009358A GB0009358A GB2351151B GB 2351151 B GB2351151 B GB 2351151B GB 0009358 A GB0009358 A GB 0009358A GB 0009358 A GB0009358 A GB 0009358A GB 2351151 B GB2351151 B GB 2351151B
- Authority
- GB
- United Kingdom
- Prior art keywords
- screening method
- compound screening
- nematode worms
- nematode
- worms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000244206 Nematoda Species 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
- A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5085—Supracellular entities, e.g. tissue, organisms of invertebrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
- G01N2333/43526—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms
- G01N2333/4353—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes
- G01N2333/43534—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes from Caenorhabditis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Environmental Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Pharmacology & Pharmacy (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0111713A GB2359359B (en) | 1999-04-15 | 2000-04-14 | Compound screening method |
GB0111712A GB2359358B (en) | 1999-04-15 | 2000-04-14 | Compound screening method |
GB0111778A GB2359627B (en) | 1999-04-15 | 2000-04-14 | Compound screening method |
GB0111714A GB2359626B (en) | 1999-04-15 | 2000-04-14 | Compound screening method |
GB0111787A GB2359361B (en) | 1999-04-15 | 2000-04-14 | Compound screening method |
GB0111783A GB2359360B (en) | 1999-04-15 | 2000-04-14 | Compound screening method |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12959699P | 1999-04-15 | 1999-04-15 | |
GBGB9908670.4A GB9908670D0 (en) | 1999-04-15 | 1999-04-15 | Compound screening method |
Publications (3)
Publication Number | Publication Date |
---|---|
GB0009358D0 GB0009358D0 (en) | 2000-05-31 |
GB2351151A GB2351151A (en) | 2000-12-20 |
GB2351151B true GB2351151B (en) | 2001-07-25 |
Family
ID=26315417
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB0009358A Expired - Fee Related GB2351151B (en) | 1999-04-15 | 2000-04-14 | Compound Screening Method in Nematode Worms |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1175506A2 (ja) |
JP (1) | JP2002542466A (ja) |
AU (1) | AU780574B2 (ja) |
CA (1) | CA2365707A1 (ja) |
GB (1) | GB2351151B (ja) |
HK (1) | HK1030047A1 (ja) |
HU (1) | HUP0201142A2 (ja) |
MX (1) | MXPA01010175A (ja) |
PL (1) | PL351432A1 (ja) |
WO (1) | WO2000063427A2 (ja) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000011449A1 (en) | 1998-08-21 | 2000-03-02 | Union Biometrica, Inc. | Instrument for selecting and depositing multicellular organisms and other large objects |
AU5299200A (en) * | 1999-05-27 | 2000-12-18 | Pharmacia & Upjohn Company | A nematode drug screen for modulators of mammalian disorders |
WO2001070944A2 (de) * | 2000-03-22 | 2001-09-27 | Aventis Pharma Deutschland Gmbh | Nematoden als modellorganismen zur untersuchung neurodegenerativer erkrankungen und insbesonder der parkinsonschen erkrankung, verwendungen und verfahren zum auffinden von substanzen und genen, die bei der behandlung solcher erfrankungen eingesetz werden können, sowie identifizierung eines nematodengens. |
US7083947B2 (en) | 2000-05-19 | 2006-08-01 | Devgen Nv | Assay techniques using nematode worms |
GB0012229D0 (en) | 2000-05-19 | 2000-07-12 | Devgen Nv | Lipid uptake assays |
US20030138803A1 (en) * | 2001-07-27 | 2003-07-24 | Brooksbank Robert Alan | Identification and use of molecules implicated in pain |
US20040058326A1 (en) * | 2001-07-27 | 2004-03-25 | Brooksbank Robert Alan | Identification and use of molecules implicated in pain |
US20030134301A1 (en) * | 2001-07-27 | 2003-07-17 | Brooksbank Robert Alan | Identification and use of molecules implicated in pain |
AU2002343512B2 (en) | 2001-10-15 | 2007-12-06 | E.I. Du Pont De Nemours And Company | Iminobenzoxazines, iminobenzthiazines and iminoquinazolines for controlling invertebrate pests |
US20080038198A1 (en) * | 2004-01-05 | 2008-02-14 | Mitsubishi Pharma Corporation | Method Of Screening Molecule Associated With Psychiatric Disorder |
KR100848790B1 (ko) * | 2006-12-27 | 2008-07-30 | 연세대학교 산학협력단 | 소나무 재선충, 다이플로스캡터 및 예쁜 꼬마선충에 대한살선충제의 고속 스크리닝 방법 |
WO2011017319A1 (en) | 2009-08-03 | 2011-02-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods of treating disorders associated with protein polymerization |
US9072772B2 (en) | 2009-11-05 | 2015-07-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods of treating disorders associated with protein aggregation |
US8809617B2 (en) * | 2009-11-05 | 2014-08-19 | The University of Pittsburgh—Of the Commonwealth System of Higher Education | Automated high-content live animal drug screening using C. elegans |
KR101764832B1 (ko) * | 2015-04-27 | 2017-08-03 | 서울시립대학교 산학협력단 | 산화 스트레스 유발 물질 스크리닝용 bli-3 유전자 기능이 저하된 C. elegans 및 이를 이용한 산화 스트레스 유발 물질 스크리닝 방법 |
CN111066735A (zh) * | 2019-12-24 | 2020-04-28 | 深圳市铁汉生态环境股份有限公司 | 一种用于昆虫取食量测量的饲养装置 |
CN112379064B (zh) * | 2020-11-18 | 2021-08-13 | 浙江省林业科学研究院 | 一种高通量筛选松材线虫抑制剂的方法 |
KR102706633B1 (ko) * | 2023-01-05 | 2024-09-12 | 한림대학교 산학협력단 | 신경독성이 유도된 예쁜꼬마선충 동물모델 및 그 제조방법 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990009096A2 (en) * | 1989-02-03 | 1990-08-23 | Cambridge Neuroscience Research, Inc. | Method of screening and classifying compounds |
WO1996038555A2 (en) * | 1995-05-31 | 1996-12-05 | Thierry Bogaert | Unc-53 from c. elegans and its uses in testing compounds involved in the control fo cell behaviour and pharmaceutical compositions |
WO1998053856A1 (en) * | 1997-05-29 | 1998-12-03 | The General Hospital Corporation | Methods for the detection, treatment, and prevention of neurodegeneration |
WO1999002652A1 (en) * | 1997-07-11 | 1999-01-21 | The General Hospital Corporation | Transgenic nematode model of triplet repeat neurological diseases |
WO2000040711A2 (en) * | 1999-01-06 | 2000-07-13 | California Institute Of Technology | Polycystic kidney disease gene homologs required for male mating behavior in nematodes and assays based thereon |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55153599A (en) * | 1979-05-18 | 1980-11-29 | Duskin Franchise Co Ltd | Toxic test method of chemical substance by using nematode |
US6461854B1 (en) * | 1995-03-28 | 2002-10-08 | The General Hospital Corporation | Methods of screening compounds useful for prevention of infection or pathogenicity |
US7166270B1 (en) * | 1995-03-28 | 2007-01-23 | The Netherlands Cancer Institute | Methods of screening compounds useful for prevention of infection or pathogenicity |
WO1997011956A1 (en) * | 1995-09-27 | 1997-04-03 | The Trustees Of Columbia University In The City Of New York | IDENTIFICATION OF sel-12 AND USES THEREOF |
EP1019092A4 (en) * | 1997-05-15 | 2004-12-15 | Gen Hospital Corp | THERAPEUTIC AND DIAGNOSTIC TOOLS FOR POOR CARBOHYDRATE TOLERANCE |
US6278039B1 (en) * | 1997-05-28 | 2001-08-21 | Axys Pharmaceuticals, Inc. | C. elegans deletion mutants |
WO1999002684A1 (en) * | 1997-07-09 | 1999-01-21 | University Technology Corporation | Methods of identifying and screening genes associated with increased longevity and slowed aging |
US6087153A (en) * | 1997-07-24 | 2000-07-11 | The Trustees Of Columbia University In The City Of New York | Sel-10 and uses thereof |
GB9826890D0 (en) * | 1998-12-07 | 1999-01-27 | Devgen Nv | Method for screening compounds |
-
2000
- 2000-04-14 EP EP00920972A patent/EP1175506A2/en not_active Withdrawn
- 2000-04-14 MX MXPA01010175A patent/MXPA01010175A/es unknown
- 2000-04-14 HU HU0201142A patent/HUP0201142A2/hu unknown
- 2000-04-14 AU AU41376/00A patent/AU780574B2/en not_active Ceased
- 2000-04-14 CA CA002365707A patent/CA2365707A1/en not_active Abandoned
- 2000-04-14 PL PL00351432A patent/PL351432A1/xx not_active Application Discontinuation
- 2000-04-14 JP JP2000612504A patent/JP2002542466A/ja active Pending
- 2000-04-14 GB GB0009358A patent/GB2351151B/en not_active Expired - Fee Related
- 2000-04-14 WO PCT/IB2000/000575 patent/WO2000063427A2/en active Application Filing
-
2001
- 2001-01-17 HK HK01100427A patent/HK1030047A1/xx not_active IP Right Cessation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990009096A2 (en) * | 1989-02-03 | 1990-08-23 | Cambridge Neuroscience Research, Inc. | Method of screening and classifying compounds |
WO1996038555A2 (en) * | 1995-05-31 | 1996-12-05 | Thierry Bogaert | Unc-53 from c. elegans and its uses in testing compounds involved in the control fo cell behaviour and pharmaceutical compositions |
WO1998053856A1 (en) * | 1997-05-29 | 1998-12-03 | The General Hospital Corporation | Methods for the detection, treatment, and prevention of neurodegeneration |
WO1999002652A1 (en) * | 1997-07-11 | 1999-01-21 | The General Hospital Corporation | Transgenic nematode model of triplet repeat neurological diseases |
WO2000040711A2 (en) * | 1999-01-06 | 2000-07-13 | California Institute Of Technology | Polycystic kidney disease gene homologs required for male mating behavior in nematodes and assays based thereon |
Also Published As
Publication number | Publication date |
---|---|
WO2000063427A2 (en) | 2000-10-26 |
GB2351151A (en) | 2000-12-20 |
WO2000063427A3 (en) | 2001-12-06 |
HUP0201142A2 (en) | 2002-08-28 |
JP2002542466A (ja) | 2002-12-10 |
AU4137600A (en) | 2000-11-02 |
AU780574B2 (en) | 2005-04-07 |
MXPA01010175A (es) | 2002-04-09 |
CA2365707A1 (en) | 2000-10-26 |
EP1175506A2 (en) | 2002-01-30 |
GB0009358D0 (en) | 2000-05-31 |
HK1030047A1 (en) | 2001-04-20 |
PL351432A1 (en) | 2003-04-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20090414 |