GB2304573A - Skin care composition comprising sunscreen, humectant and exfolliant - Google Patents

Skin care composition comprising sunscreen, humectant and exfolliant Download PDF

Info

Publication number
GB2304573A
GB2304573A GB9517711A GB9517711A GB2304573A GB 2304573 A GB2304573 A GB 2304573A GB 9517711 A GB9517711 A GB 9517711A GB 9517711 A GB9517711 A GB 9517711A GB 2304573 A GB2304573 A GB 2304573A
Authority
GB
Grant status
Application
Patent type
Prior art keywords
weight
parts
skin
composition
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9517711A
Other versions
GB2304573B (en )
GB9517711D0 (en )
Inventor
Sean Campbell
Marion Edsor
John Herd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
* FERNSOFT
FERNSOFT
Original Assignee
Fernsoft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365Hydroxycarboxylic acids; Ketocarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/671Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/676Ascorbic acid, i.e. vitamin C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/72Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/96Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants

Abstract

Cosmetic skin care composition comprising a sunscreen e.g . octylmethoxy cinnamate, emollient e.g. glyceryl stearate, humectant e.g . glycerin, anti-oxidant e.g . Vitamins A/C/E, exfolliant e.g . * small Greek alpha *-hydroxy acids from fruit extract, bodifier e.g. cetyl alcohol, emulsifier e.g . sorbitan stearate, preservative e.g . propyl paraben, sequestering agent e.g. disodium EDTA, delivery agent, e.g. phytantriol and water. Vitamins A and C may be in liposomal form.

Description

Title: "Cosmetic product" THE PRESENT INVENTION relates to a cosmetic product and, more particularly, to a formulation for cosmetic treatment of human skin.

The field of cosmetic skin care is one that has provided intense investigation for centuries. There are currently available a wide number of skin care products.

These have many different functions, from skin cleaning to skin moisturization.

The interest in such formulations stems from the human desire to appear attractive and, therefore, to care for the appearance. This, coupled with the desire to, as far as possible, prevent the outward signs of ageing, leads to the market for skin care products being a very large one.

A superior skin care product should have several properties. First and foremost, such a product should provide moisture to the skin. This may be achieved by several different approaches, for example, by maintaining the integrity of the outermost layer of skin cells, the stratum corneum, by controlling transepidermal water loss, or by ensuring that the skin obtains sufficient vitamins so as to maintain anti-oxidation properties, collagen production and rate of mitosis.

Further desired properties of a skin care product include the reduction in pigmentation spots on the skin, healing of damaged skin cells and screening from W radiation. Ideally such a skin formulation should also be anti-allergenic.

According to the present invention, there is provided a stable skin care composition comprising a sunscreen, humectant, exfoliant, emulsifier, preservative and water.

Preferably, the composition comprises from 0.5 to 30.0 parts by weight of sunscreen, 10.0 to 25.0 parts by weight emollient, 1.0 to 20.0 parts by weight humectant, 1.0 to 30.0 parts by weight exfolliant, 1.0 to 35.0 parts by weight anti-oxidant, 1.0 to 10.0 parts by weight bodifier, 1.0 to 10.0 parts by weight emulsifier, 1.0 to 20.0 parts by weight moisturiser, 0.1 to 1.0 parts by weight preservative, 0.05 to 0.5 parts by weight sequestering agent, 0.1 to 1.0 parts by weight delivery agent and 30.0 to 70.0 parts by weight water.

More preferably the composition comprises 10.5 to 20.0 parts by weight sunscreen, 12.5 to 19.5 parts by weight emollient, 5.0 to 10.0 parts by weight humectant, 9.0 to 19.0 parts by weight exfolliant, 10.0 to 22.4 parts by weight antioxidant, 2.0 to 5.0 parts by weight bodifier, 2.5 to 6.0 parts by weight emulsifier, 4.2 to 12.5 parts by weight moisturiser, 0.3 to 0.8 parts by weight preservative, 0.1 to 0.3 parts by weight sequestering agent, 0.2 to 0.5 parts by weight delivery agent and 47.0 to 55.0 parts by weight water.

Preferably the sunscreen comprises at least one of octyl methoxycinnamate and benzophenone-3.

Preferably the emollient comprises at least one of mineral oil, glyceryl stearate, Peg-100 stearate, Vitamin B5 and evening primrose oil.

Preferably the Vitamin B5 is in the form of Dpanthenol, most preferably contained in wheatgerm oil.

Preferably the humectant is glycerin.

It is preferred that the exfolliant is an alphahydroxy acid, for example a melon extract or mixed fruit extract.

It is preferred that the anti-oxidant is a free radical scavenger preferably comprising at least one of superoxide dismutase, Vitamin A, Vitamin E, Vitamin C and BHA.

Preferably the percentage by weight of BHA is from 0.09 to 0.11, and most preferably is 0.10.

Preferably the superoxide dismutase is provided as a mixture of water, lecthin and superoxide dismutase.

Preferably the Vitamin E is present as at least one of tocopheryl acetate and tocopheryl linoleate, preferably in the form of both.

Preferably the Vitamin A is in the form of retinyl palmitate.

Preferably the Vitamin C is in the form of ascorbyl polypeptide.

Preferably the bodifier comprises cetyl alcohol.

Preferably the emulsifier comprises at least one of sorbitan stearate and Peg-40 stearate.

It is preferred that the emulsifier comprises glycerylstearate-Peg-100 stearate, sorbitan stearate and Peg-40 stearate. Preferably their percentages by weight are from 2.7 to 3.3, 1.35 to 1.65 and 0.9 to 1.1 respectively, and most preferably 3.0, 1.5 and 1.0 respectively.

Preferably the moisturiser comprises at least one of lysine PCA, aloe extract, lauryl PCA, sodium hyaluronate and phytantriol.

It is preferred that the preservative comprises at least one of imidazolidinyl urea, methyl paraben and propyl paraben. Preferably their percentages by weight are from 0.27 to 0.33, 0.14 to 0.17 and 0.90 to 1.10 respectively and most preferably 0.3, 0.15 and 1.0 respectively.

It is preferred that the sequestering agent is disodium EDTA. Preferably at a percentage by weight from 0.09 to 0.11 and most preferably 0.1.

Preferably the composition of the present invention comprises a composition comprising 5.0 to 15.0 parts by weight octyl methoxycinnamate, to 15.0 parts by weight mineral oil, 1.0 to 15.0 parts by weight glycerine, 1.0 to 15.0 parts by weight melon extract, 1.0 to 15.0 parts by weight water / lecthin / superoxide dismutase composition, 1.0 to 15.0 parts by weight mixed fruit extract, 1.0 to 10.0 parts by weight glyceryl stearate and/or Peg-100 stearate, 1.0 to 15.0 parts by weight benzophenone-3, 1.0 to 10.0 parts by weight tocopheryl acetate, 1.0 to 10.0 parts by weight cetyl alcohol, 0.55 parts by weight sorbitan stearate, 0.5 to 5.0 parts by weight Peg-40 stearate, 0.5 to 5.0 parts by weight retinyl palmitate, 0.5 to 5.0 parts by weight tocopheryl linoleate, 0.5 to 5.0 parts by weight lysine PCA, 0.5 to 5.0 parts by weight aloe extract, 0.5 to 5.0 parts by weight lauryl PCA, 0.5 to 5.0 parts by weight wheatgerm oil, 0.1 to 2.0 parts by weight evening primrose oil, 0.1 to 2.0 parts by weight ascorbyl polypeptide, 0.1 to 1.0 parts by weight imidazolidinyl urea, 0.1 to 1.0 part per weight phytantriol, 0.05 to 1.0 disodium EDTA, 0.05 to 1.0 part per weight BHA, 0.5 to 5.0 parts by weight sodium hyaluronate and 32.70 parts by weight water.

Most preferably the composition comprising 7.5 to 12.0 parts by weight octyl methoxycinnamate, 8.0 to 10.0 parts by weight mineral oil, 5.0 to 10.0 parts by weight glycerin, 5.0 to 10.0 parts by weight melon extract, 5.0 to 10.0 parts by weight water / lecthin / superoxide dismutase composition, 4.0 to 9.0 parts by weight mixed fruit extract, 3.0 to 5.0 parts by weight gluceryl stearate and/or Peg-100 stearate, 3.8 parts by weight benzophenone3, 2.5 to 5.0 parts by weight tocopheryl acetate, 2.0 to 5.0 parts by weight cetyl alcohol, 1.5 to 3.0 parts by weight sorbitol stearate, 1.0 to 3.0 parts by weight sorbitol stearate, 1.0 to 3.0 parts by weight peg-40 stearate, 1.0 to 3.0 parts by weight retinyl palmitate, 1.0 to 3.0 parts by weight tocopheryl linoleate, 1.0 to 3.0 parts by weight lysine PCA, 1.0 to 3.0 parts by weight aloe extract, 1.0 to 3.0 parts by weight lauryl PCA, 1.0 to 3.0 parts by weight wheatgerm oil, 0.5 to 1.5 parts by weight evening primrose oil, 0.4 to 1.0 part per weight ascorbyl polypeptide, 0.3 to 0.8 parts by weight imidazolidinyl urea, 0.2 to 0.5 parts by weight phytantriol, 0.1 to 0.3 disodium EDTA, 0.1 to 0.4 parts by weight BHA, 1.0 to 3.0 parts by weight sodium hyaluronate and 47.0 to 55.0 parts by weight water.

The composition of the present invention is hypoallergenic and serves to moisturise and cosmetically improve the skin in several ways.

According to the present invention there is further provided a method of cosmetic treatment of skin comprising applying to skin a composition according to the present invention.

According to the present invention there is still further provided a composition according to the present invention for use as a medicament, preferably for the treatment of damaged skin.

The composition of the present invention and method of using same allows for preservation and renewal of skin cells, thickening of the skin, increase in collagen production thereby reducing wrinkles, prevention of excess of moisture loss and anti-oxidation. One of the problems encountered in prior art compositions is the problem of delivery of ingredients to the appropriate skin layer as well as the stabilisation of said ingredients. In the present invention, delivery of the ingredients is solved by the use of a delivery agent, preferably phytantriol. The use of phytantriol allows all the ingredients of the composition to be drawn deep into the skin. Phytantriol is particularly preferred because it also has moisturising and emolliant properties.

Furthermore, both Vitamin A, in the form of retinyl palmitate, the evening primrose oil and Vitamin C are all delivered in the form of liposomes. This allows greater stability of these ingredients as well as allowing much greater ease of delivery to the deeper layers of the skin.

Furthermore, the delivery of Vitamin C in the form of liposomes allows the Vitamin C to penetrate as deeply as the Vitamin A and, therefore, allows the Vitamin C to stabilise the Vitamin A. The Vitamin A is further stabilised by Vitamin E. In this respect, Vitamin E is preferably provided in the form of tocopheryl linoleate, the linoleate being of a form to allow easy absorption into the skin by its increased fat solubility.

In this respect it should be noted that oral ingestion of vitamins is a poor way to deliver vitamins to the skin. However, until recently, there was no other way of delivering vitamins to the deeper layers of the skin because of the inherent water solubility of Vitamins A, C and E and, therefore, their inability to penetrate the deeper layers of skin. By encasing these vitamins in liposomes and, therefore, effectively making them fat soluble, deep penetration by these vitamins into the skin has been achieved, allowing effective vitamin delivery to the skin.

It is preferred that the composition of the present invention comprises a UV absorber to act as a sunscreen.

The most preferred compound in this respect is octyl methoxycinnamate or benzophenone-3.

A number of emollients may be used to cause the cells to remain plump for longer. Such emollients include mineral oil, glyceryl stearate, Peg-100 stearate and evening primrose oil. In this respect, glyceryl monostearate also acts as a thickening agent and emulsifier. The thickened skin causes less moisture loss and, therefore, reduces contraction of collagen supporting the skin so as to prevent wrinkles.

Vitamin B5 is preferably applied in the form of Dpanthenol contained in wheatgerm oil. This also acts as an emollient but, further, has been shown to heal damaged skin cells to restore strength to the previously damaged skin.

The humectant in the composition according to the present invention is preferably glycerin, 1, 2, 3 propane triol, which softens skin. The humectant aids in the process of setting up protective barriers to prevent damage to the skin.

It is preferred that <RTI>alpha-hydroxyl</RTI> acids are used as exfolliants to encourage decarotenisation of the skin and, thereby, increase skin softening. It is preferred that such alpha-hydroxy acids be provided in natural form, such as melon extract or mixed fruit extract. The use of alpha-hydroxy acids in relatively mild concentrations (10%) have been shown to soften the skin rapidly and increase skin sensitivity.

Cetyl alcohol is the preferred bodifier.

It is important that the composition of the present invention is an emulsion to encourage absorption into the skin. The preferred emulsification system, efficient in stabilising the remaining ingredients comprises glyceryl stearate-peg-100 stearate, sorbitan stearate and peg-40 stearate.

Several of the ingredients of the composition are relatively unstable such as, for example, the vitamins and their derivatives and the fruit extracts. For this reason, it is preferred that the composition be made with a preservative which may be selected from the group of methyl paraben, propyl paraben and imidazolidinyl urea.

Imidazolidinyl urea also has anti-oxidant properties.

The composition according to the present invention should have a sequestering agent, preferably Disodium EDTA.

Of course, a cosmetic skin care composition, the main function of which is to moisturise the skin should have, as a component, a moisturiser. In the present invention it is preferred that the moisturising component of the composition comprises at least one of lysine PCA, aloe extract, lauryl PCA, phytantriol and sodium hyaluronate. These compounds moisturise the skin.

Furthermore, lysine PCA and lauryl PCA draw oxygen into the skin thereby ensuring that the skin is fully oxidated to decrease the rate of skin cell death. Hyaluronate acid provides a surface barrier, preventing moisture from escaping the skin whilst still allowing the skin to breathe. In this respect, sodium hyaluronate is capable of absorbing and holding more water than any other natural or synthetic polymer known today. When applied to the skin's surface it forms an extremely thin elastic film very similar to the natural keratin film on skin. This film is permeable to oxygen and yet provides an effective seal against moisture loss.

As described above, phytantriol is not only important as a moisturiser but, even more importantly, as a delivery vehicle to allow delivery of Vitamin A in liposome form to the cells of the skin.

Probably the most important component of the composition of the present invention, however, is the antioxidant component. This component comprises several antioxidants and free-radical scavengers which may include superoxide dismutase, BHA, Vitamin A, Vitamin C and Vitamin E. These are natural ingredients, the main function of which is to quench free radicals caused by spontaneous ionisation of compounds within the cells. Free radicals produced by such spontaneous ionisation are thought to be a major cause of the ageing process, causing cellular damage and eventually breakdown. These natural free radical scavengers are compounds which react with the free radicals so as to prevent the free radicals reacting with any other compound and, particularly, to prevent potentially damaging chain reactions within the cell.

The Vitamins A, C and E also have extremely important secondary effects as well as their primary effect of free radical scavaging.

Vitamin A, delivered in liposomes in the form of retinyl palmitate, has the effect of stimulating mitosis in the germanative layers of the skin. This increase in cell duplication increases the thickness of the skin so as to cause increased moisture retention and decreased collagen contraction, leading to a decrease in wrinkles. It is thought that retinyl palmitate in the skin is converted to retinoic acid. This is thought to prevent connective tissue atrophy and to regenerate connective tissue to aid dermal repair in response to UV damage. This allows an accumulation of collagen in the skin to aid repair of the skin. The increased mitopic effects observed when Vitamin A is applied give the more youthful looking skin because the stimulatory effects of the vitamin tend to oppose those changes that occur with ageing. The skin is activated to produce more epidermal protein and form a thicker epidermis which is covered by a better formed keratin layer.

Furthermore, the elasticity of the skin is increased.

Vitamin A also stimulates dermal repair in response to W damage, particularly after exposure to the sun.

The advantages of applying Vitamin A in liposomes is not only the greater effectiveness in delivery, as discussed above. Vitamin A can sometimes lead to sensitivity in some users. However, the use of liposomes, prevents direct contact with Vitamin A and the outer layer of the skin thus avoiding such sensitisation. Furthermore, the use of liposomes for delivery of Vitamin A allows an extended and progressive release time for the Vitamin A.

Until recently, retinyl palmitate was up to 25% oxidised within four weeks of production. It is, therefore, preferable that at least one of Vitamins C and E be incorporated into the present composition for their further advantageous property as anti-oxidants, preventing the oxidation and decomposition of the retinyl palmitate.

Vitamin C, too, has several other advantageous properties over and above its free radical scavenging.

Vitamin C causes melanin dispersion and, therefore, aids in the reduction or elimination in brown pigmentation spots, associated with ageing, on the surface of the skin.

Furthermore, Vitamin C, closely associated with wound healing, has been found to stimulate collagen synthesis, vital for maintaining skin tone. Vitamin C is also known for its sunscreen properties. It should be noted that Vitamin C is preferentially depleted from the skin by the body, from the skin in order to sustain other bodily functions. It is, therefore, very important to ensure that the skin is properly supplied with the Vitamin C.

Vitamin E also has many advantageous properties other than its free-radical scavaging. It is a well-known anti-oxidant and, as such, acts as an anti-oxidising preservative in the composition itself. Furthermore, Vitamin E stimulates an increase in protein, DNA and acylglycosyl ceramide production. Vitamin E is a lipid soluble oxidant as opposed to Vitamin C which is a water soluble anti-oxidant. Vitamin E is also an effective sunscreen, acting against sunburn created by UVB radiation.

Vitamin E has been found to reduce skin roughness and facial lines and wrinkles.

Vitamin E may be used in one or both of two preferred forms. The first preferred form is tocopheryl linoleate. It is preferred that this is manufactured using gamma linolenic acid, which is derivable from evening primrose oil. This acid supplements the lipids which underlie and support the skin, penetrating deeply into the skin and storing within the cell walls to ensure that the cells stay plump for longer. Furthermore, the linolenic acid, on its own, may be irritating but Vitamin E linoleate is non-toxic and allows the Vitamin E to be easily absorbed whilst allowing the linoleic acid to have its own advantageous effects without irritation. Vitamin E linolate also reduces the transepidermal water loss.

Linolenic acid is an essential fatty acid and, therefore, tocopheryl linoleate aids in correcting essential fatty acid deficiencies.

The alternative form of Vitamin E is Vitamin E acetate or tocopheryl acetate. This also reduces transepidermal water loss, appearing to moisturise from within as opposed to having a occlusive effect. Vitamin E acetate accumulates in the stratum corneum and, after natural conversion by the skin enzymes, is incorporated into the lipid bilayers so as to repair the intracellular moisturising barrier of the skin.

Vitamins A, C and E also have two other major effects. Along with gamma linolenic acid, these three vitamins prevent a decrease in sebaceous and sweat gland production by retarding sebaceous glands from their natural decrease in production with age.

Of more importance is the particular anti-oxidation effects at the border of the dermis and the epidermis which is the area in which the chief production of skin cancer appears to take place. Accordingly, Vitamins A, C and E would appear to be of major prophylactic use in the prevention of skin cancer.

The composition of the present invention may also comprise artificial or natural colour in small concentrations, for example from 0.1 to 0.2 parts by weight. Yellow number 6FD and C and red number 40FD and C may be used in this respect.

A skin care composition according to the present invention was prepared.

To prepare the composition, de-ionised water was passed into a 200 gallon steam jacketed kettle fitted with a motorized stirrer. Glycerin, EDTA disodium de-panthenol, aloe vera and methyl parabin were added.

In a second vessel, glyceryl stearate, Peg-100 stearate, sorbitan stearate, mineral oil, lauryl PCA, cetyl alcohol, BHA, evening primrose oil, propyl paraben, wheatgerm oil, octyl methoxycinnamate, benzophenon-3 and Peg-40 stearate were mixed with a mechanical stirrer in a similar steam jacketed kettle whilst being heated to 700C.

After about 20 minutes of heating and stirring the second mixture was removed from the second steam jacketed kettle and added to the first mixture, with stirring. An emulsion was formed and was subsequently stirred whilst cooling to 45-500C.

In a third, separate vessel, phytentriol, tocopheryl linoleate, tocopheryl acetate and retinyl palmetate were mixed. The third mixture was then added to the emulsion formed between the first and second mixture with stirring. The subsequent emulsion was cooled, whilst stirring, to 350C.

A fourth mixture combing water, ascorbyl polypeptide, imidazolidinyl urea, sodium hyaluronate, lysine PCA, mixed fruit extracts, melon extract and water / lecthin / superoxide dismutase were mixed. This fourth mixture was added, at 350C, to the emulsion formed by the previous three mixtures and the emulsion was mixed until uniform to form the product for use. A small amount (approximately a quarter of an ounce) of this product was completely massaged into human facial skin for a period of one to two minutes daily. After two weeks of such daily use, re-vitalisation of the treated skin can be seen, incorporating improvement of skin texture, colour and clarity and reduction in fine lines.

The composition of the present invention is simply massaged into the facial skin to preserve and renew the vitality of the skin cells. Daily massage of the composition into the skin maintains the health, elasticity and vitality of the skin, reduces or eliminates blemishes and brown spots, stimulates the sebaceous glands and tones the skin. Its softens, smooths and stimulates the skin and combines, with the massaging effect, to assist circulation in the skin. Continued use of the composition prevents excessive moisture loss and aids growth and health of the skin.

Claims (54)

1. A stable skin care composition comprising a sunscreen, humectant, exfolliant, emulsifier, preservative and water.
2. A composition according to Claim 1 comprising from 5.0 to 30.0 parts by weight of sunscreen, 10.0 to 25.0 parts by weight emollient, 1.0 to 20.0 parts by weight humectant, 1.0 to 30.0 parts by weight exfolliant, 1.0 to 35.0 parts by weight anti-oxidant, 1.0 to 10.0 parts by weight bodifier, 1.0 to 10.0 parts by weight emulsifier, 1.0 to 20.0 parts by weight moisturiser, 0.1 to 1.0 parts by weight preservative, 0.05 to 0.5 parts by weight sequestering agent, 0.1 to 1.0 parts by weight delivery agent and 30.0 to 70.0 parts by weight water.
3. A composition according to Claim 1 or 2 comprising 10.5 to 20.0 parts by weight sunscreen, 12.5 to 19.5 parts by weight emollient, 5.0 to 10.0 parts by weight humectant, 9.0 to 19.0 parts by weight exfolliant, 10.0 to 22.4 parts by weight antioxidant, 2.0 to 5.0 parts by weight bodifier, 2.5 to 6.0 parts by weight emulsifier, 4.2 to 12.5 parts by weight moisturiser, 0.3 to 0.8 parts by weight preservative, 0.1 to 0.3 parts by weight sequestering agent, 0.2 to 0.5 parts by weight delivery agent and 47.0 to 55.0 parts by weight water.
4. A composition according to any preceding claim wherein the sunscreen comprises octyl methoxycinnamate or benzophenone-3.
5. A composition according to any preceding claim, wherein the emollient comprises mineral oil, glyceryl stearate, Peg-100 stearate, Vitamin B5 or evening primrose oil.
6. A composition according to Claim 5 wherein the emollient comprises Vitamin B5.
7. A composition according to Claim 6 wherein the Vitamin B5 is in the form of D panthenol.
8. A composition according to Claim 7, wherein the depanthenol is incorporated in wheatgerm oil.
9. A composition according to any one of the preceding claims wherein the humectant comprises glycerin.
10. A composition according to any one of the preceding claims wherein the exfolliant comprises an alphahydroxy acid.
11. A composition according to Claim 10 wherein the alphahydroxy acid is contained in melon extract or mixed fruit extracts.
12. A composition according to any one of the preceding claims wherein the antioxidant comprises superoxide dismutase, BHA, Vitamin E, Vitamin A or Vitamin C.
13. A composition according to Claim 12, wherein the antioxidant comprises BHA.
14. A composition according to Claim 13, wherein the percentage by weight of BHA is from 0.09 to 0.11.
15. A composition according to Claim 14, wherein the percentage by weight of BHA is 0.10.
16. A composition according to Claim 12, wherein the antioxidant is Vitamin E.
17. A composition according to Claim 16 wherein the Vitamin E is in the form of tocopheryl acetate or tocopheryl linoleate.
18. A composition according to any of Claims 12 to 17 wherein the antioxidant comprises Vitamin C.
19. A composition according to Claim 18 wherein the Vitamin C is in the form of ascorbyl polypeptide.
20. A composition according to any one of Claims 11 to 19 wherein the antioxidant comprises Vitamin A.
21. A composition according to Claim 20, wherein the vitamin A is in the form of retinyl palmitate.
22. A composition according to any one of the preceding claims wherein the bodifier is cetyl alcohol.
23. A composition according to any one of the preceding claims wherein the emulsifier comprises sorbitan stearate or Peg-40 stearate.
24. A compostion according to Claim 23, wherein the emulsifier comprises glyceryl stearate-Peg-100 stearate, sorbitan stearate and Peg-40 stearate.
25. A composition according to Claim 24, wherein the percentage by weight of glyceryl stearate-Peg-100 stearate is from 2.7 to 3.3.
26. A composition according to Claim 25, wherein the percentage by weight of glyceryl stearate-Peg-100 stearate is 3.0.
27. A composition according to any one of Claims 24 to 26, wherein the percentage by weight of sorbitan stearate is from 1.35 to 1.65.
28. A composition according to Claim 27 wherein the percentage by weight of sorbitan stearate is 1.5.
29. A composition according to any one of Claims 24 to 28 wherein the percentage by weight of Peg-40 stearate is from 0.9 to 1.1.
30. A composition according to Claim 29 wherein the percentage by weight of Peg-40 stearate is 1.0.
31. A composition according to any one of the preceding claims wherein the moisturiser comprises lysine PCA, aloe extract, lauryl PCA or sodium hyaluronate.
32. A composition according to any one of the preceding claims wherein the preservative comprises imidazolidinyl urea.
33. A composition according to Claim 32 wherein the preservative comprises propyl paraben, methyl paraben and imidazolidinyl urea.
34. A composition according to Claim 33, wherein the percentage by weight of propyl paraben is from 0.90 to 1.10.
35. A composition according to Claim 34 wherein the percentage by weight of propyl paraben is 0.1.
36. A composition according to any one of Claims 33 to 35, wherein the percentage by weight of methyl paraben is from 0.14 to 0.17.
37. A composition according to Claim 36, wherein the percentage by weight of methyl paraben is 0.15.
38. A composition according to any one of Claims 33 to 37, wherein the percentage by weight of imidazolidinyl urea is from 0.27 to 0.33.
39. A composition according to any one of Claims 38, wherein the percentage by weight of imidazolidinyl urea is 0.30.
40. A composition according to any one of the preceding claims wherein the sequestering agent comprises disodium EDTA.
41. A composition according to Claim 40, wherein the percentage by weight of disodium EDTA is from 0.09 to 0.11.
42. A composition according to Claim 41, wherein the percentage by weight of disodium EDTA is 0.10.
43. A composition according to any one of the preceding claims wherein the delivery agent comprises phytantriol.
44. A composition according to any one of the preceding claims comprising 5.0 to 15.0 parts by weight octyl methoxycinnamate, to 15.0 parts by weight mineral oil, 1.0 to 15.0 parts by weight glycerine, 1.0 to 15.0 parts by weight melon extract, 1.0 to 15.0 parts by weight water / lecthin / superoxide dismutase composition, 1.0 to 15.0 parts by weight mixed fruit extract, 1.0 to 10.0 parts by weight glyceryl stearate and/or Peg-100 stearate, 1.0 to 15.0 parts by weight benzophenone-3, 1.0 to 10.0 parts by weight tocopheryl acetate, 1.0 to 10.0 parts by weight cetyl alcohol, 0.55 parts by weight sorbitan stearate, 0.5 to 5.0 parts by weight Peg-40 stearate, 0.5 to 5.0 parts by weight retinyl palmitate, 0.5 to 5.0 parts by weight tocopheryl linoleate, 0.5 to 5.0 parts by weight lysine PCA, 0.5 to 5.0 parts by weight aloe extract, 0.5 to 5.0 parts by weight lauryl PCA, 0.5 to 5.0 parts by weight wheatgerm oil, 0.1 to 2.0 parts by weight evening primrose oil, 0.1 to 2.0 parts by weight ascorbyl polypeptide, 0.1 to 1.0 parts by weight imidazolidinyl urea, 0.1 to 1.0 part per weight phytantriol, 0.05 to 1.0 disodium EDTA, 0.05 to 1.0 part per weight BHA, 0.5 to 5.0 parts by weight sodium hyaluronate and 32.70 parts by weight water.
45. A composition according to Claim 44, comprising 7.5 to 12.0 parts by weight octyl methoxycinnamate, 8.0 to 10.0 parts by weight mineral oil, 5.0 to 10.0 parts by weight glycerin, 5.0 to 10.0 parts by weight melon extract, 5.0 to 10.0 parts by weight water / lecthin / superoxide dismutase composition, 4.0 to 9.0 parts by weight mixed fruit extract, 3.0 to 5.0 parts by weight gluceryl stearate and/or Peg-100 stearate, 3.8 parts by weight benzophenone3, 2.5 to 5.0 parts by weight tocopheryl acetate, 2.0 to 5.0 parts by weight cetyl alcohol, 1.5 to 3.0 parts by weight sorbitol stearate, 1.0 to 3.0 parts by weight sorbitol stearate, 1.0 to 3.0 parts by weight peg-40 stearate, 1.0 to 3.0 parts by weight retinyl palmitate, 1.0 to 3.0 parts by weight tocopheryl linoleate, 1.0 to 3.0 parts by weight lysine PCA, 1.0 to 3.0 parts by weight aloe extract, 1.0 to 3.0 parts by weight lauryl PCA, 1.0 to 3.0 parts by weight wheatgerm oil, 0.5 to 1.5 parts by weight evening primrose oil, 0.4 to 1.0 part per weight ascorbyl polypeptide, 0.3 to 0.8 parts by weight imidazolidinyl urea, 0.2 to 0.5 parts by weight phytantriol, 0.1 to 0.3 disodium EDTA, 0.1 to 0.4 parts by weight BHA, 1.0 to 3.0 parts by weight sodium hyaluronate and 47.0 to 55.0 parts by weight water.
46. A composition according to Claim 44 or 45 further comprising methyl paraben or propyl paraben.
47. A composition according to any one of the preceding claims wherein at least one component is encapsulated in liposomes.
48. A composition according to Claim 47 wherein the component encapsulated in liposomes comprises retinyl palmitate, ascorbyl polypeptide or evening primrose oil.
49. A method of cosmetic treatment of skin comprising applying to skin a composition according to any one of the preceding claims.
50. A composition according to any one of Claims 1 to 48 for use as a medicament.
51. A composition according to Claim 50 for use in the treatment of damaged skin.
52. A skin care composition substantially as hereinbefore described.
53. A method of cosmetic treatment of skin substantially as hereinbefore described.
54. Any novel feature or combination of features described herein.
GB9517711A 1995-08-31 1995-08-31 Cosmetic product Expired - Lifetime GB2304573B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9517711A GB2304573B (en) 1995-08-31 1995-08-31 Cosmetic product

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9517711A GB2304573B (en) 1995-08-31 1995-08-31 Cosmetic product

Publications (3)

Publication Number Publication Date
GB9517711D0 GB9517711D0 (en) 1995-11-01
GB2304573A true true GB2304573A (en) 1997-03-26
GB2304573B GB2304573B (en) 1999-07-28

Family

ID=10779944

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9517711A Expired - Lifetime GB2304573B (en) 1995-08-31 1995-08-31 Cosmetic product

Country Status (1)

Country Link
GB (1) GB2304573B (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997031620A2 (en) * 1996-03-01 1997-09-04 Johnson & Johnson Consumer Products, Inc. Topical compositions comprising an oil-in-water emulsion and a retinoid
WO1997047279A1 (en) * 1996-06-12 1997-12-18 Johnson & Johnson Consumer Products, Inc. Photoprotective lipophilic antioxidant compounds
US5976555A (en) * 1994-09-07 1999-11-02 Johnson & Johnson Consumer Products, Inc. Topical oil-in-water emulsions containing retinoids
EP0995428A2 (en) * 1998-08-29 2000-04-26 Beiersdorf Aktiengesellschaft Skin care composition contaning retionoids
US6193956B1 (en) 1995-09-06 2001-02-27 Johnson & Johnson Consumer Companies, Inc. Topical compositions
NL1014389C2 (en) * 2000-02-15 2001-08-16 Dija Zeist Bv Tanning preparation for the skin.
WO2002015862A1 (en) * 2000-08-22 2002-02-28 Ifac Gmbh & Co. Kg Use of l-ascorbic acid in cosmetic sunscreen emulsions
WO2002055029A2 (en) * 2001-01-16 2002-07-18 Roche Vitamins Ag Hair protection compositions
US6444647B1 (en) 1999-04-19 2002-09-03 The Procter & Gamble Company Skin care compositions containing combination of skin care actives
US6562353B1 (en) * 1998-05-12 2003-05-13 Societe L'oreal S.A. Desquamation/epidermal renewal of the skin and/or combating skin aging
EP1590009A1 (en) * 2002-10-21 2005-11-02 Allegiance Corporation Coating composition for skin-contacting surface of elastomeric articles and articles containing the same
EP1745824A1 (en) * 2005-07-19 2007-01-24 Shaolin Lohan Herbals AG Cosmetic compositions comprising vitamin E
EP1974715A1 (en) * 2007-03-31 2008-10-01 Zschimmer &amp; Schwarz GmbH &amp; Co KG Chemische Fabriken Liquid composition for impregnating wet wipes
EP2090291A1 (en) * 2008-02-14 2009-08-19 KPSS-Kao Professional Salon Services GmbH Composition for hair comprising PCA and PCA ester
JP2010501600A (en) * 2006-08-28 2010-01-21 スース,ハンス,アール. Anhydrous dermatological or cosmetic preparation containing urea

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007587A1 (en) * 1990-10-25 1992-05-14 Narhex Limited Methods and compositions for amelioration of skin wrinkles
WO1996019180A1 (en) * 1994-12-20 1996-06-27 Maybelline Intermediate Co. Skin revitalizing makeup composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4423450C2 (en) * 1994-07-05 1997-07-24 Beiersdorf Ag Inorganic pigments are used which contain alpha-hydroxy carboxylic acids and / or alpha-ketocarboxylic acids in cosmetic or dermatological preparations,
EP0828473B1 (en) * 1995-05-26 2003-07-09 Unilever N.V. A cosmetic product to prevent and correct skin damage

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007587A1 (en) * 1990-10-25 1992-05-14 Narhex Limited Methods and compositions for amelioration of skin wrinkles
WO1996019180A1 (en) * 1994-12-20 1996-06-27 Maybelline Intermediate Co. Skin revitalizing makeup composition

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6461622B2 (en) 1994-09-07 2002-10-08 Johnson & Johnson Consumer Companies, Inc. Topical compositions
US5976555A (en) * 1994-09-07 1999-11-02 Johnson & Johnson Consumer Products, Inc. Topical oil-in-water emulsions containing retinoids
US6193956B1 (en) 1995-09-06 2001-02-27 Johnson & Johnson Consumer Companies, Inc. Topical compositions
WO1997031620A3 (en) * 1996-03-01 1998-01-08 Johnson & Johnson Consumer Topical compositions comprising an oil-in-water emulsion and a retinoid
WO1997031620A2 (en) * 1996-03-01 1997-09-04 Johnson & Johnson Consumer Products, Inc. Topical compositions comprising an oil-in-water emulsion and a retinoid
WO1997047279A1 (en) * 1996-06-12 1997-12-18 Johnson & Johnson Consumer Products, Inc. Photoprotective lipophilic antioxidant compounds
US6936266B2 (en) 1998-05-12 2005-08-30 L'oreal Desquamation/epidermal renewal of the skin and/or combating skin aging
US6562353B1 (en) * 1998-05-12 2003-05-13 Societe L'oreal S.A. Desquamation/epidermal renewal of the skin and/or combating skin aging
EP0995428A2 (en) * 1998-08-29 2000-04-26 Beiersdorf Aktiengesellschaft Skin care composition contaning retionoids
EP0995428A3 (en) * 1998-08-29 2000-06-14 Beiersdorf Aktiengesellschaft Skin care composition contaning retionoids
US6444647B1 (en) 1999-04-19 2002-09-03 The Procter & Gamble Company Skin care compositions containing combination of skin care actives
NL1014389C2 (en) * 2000-02-15 2001-08-16 Dija Zeist Bv Tanning preparation for the skin.
WO2001060330A1 (en) * 2000-02-15 2001-08-23 Dija Zeist B.V. Tanning preparation for the skin
US6649149B2 (en) 2000-02-15 2003-11-18 Dija Zeist B.V. Tanning preparation for the skin
WO2002015862A1 (en) * 2000-08-22 2002-02-28 Ifac Gmbh & Co. Kg Use of l-ascorbic acid in cosmetic sunscreen emulsions
WO2002055029A3 (en) * 2001-01-16 2002-12-12 David Djerassi Hair protection compositions
WO2002055029A2 (en) * 2001-01-16 2002-07-18 Roche Vitamins Ag Hair protection compositions
EP1590009A1 (en) * 2002-10-21 2005-11-02 Allegiance Corporation Coating composition for skin-contacting surface of elastomeric articles and articles containing the same
EP1590009A4 (en) * 2002-10-22 2010-11-03 Allegiance Corp Coating composition for skin-contacting surface of elastomeric articles and articles containing the same
US8835014B2 (en) 2002-10-22 2014-09-16 Allegiance Corporation Coating composition for skin-contacting surface of elastomeric articles and articles containing the same
EP1745824A1 (en) * 2005-07-19 2007-01-24 Shaolin Lohan Herbals AG Cosmetic compositions comprising vitamin E
JP2010501600A (en) * 2006-08-28 2010-01-21 スース,ハンス,アール. Anhydrous dermatological or cosmetic preparation containing urea
EP1974715A1 (en) * 2007-03-31 2008-10-01 Zschimmer &amp; Schwarz GmbH &amp; Co KG Chemische Fabriken Liquid composition for impregnating wet wipes
EP2090291A1 (en) * 2008-02-14 2009-08-19 KPSS-Kao Professional Salon Services GmbH Composition for hair comprising PCA and PCA ester

Also Published As

Publication number Publication date Type
GB2304573B (en) 1999-07-28 grant
GB9517711D0 (en) 1995-11-01 grant

Similar Documents

Publication Publication Date Title
US6316012B1 (en) Cosmetic or pharmaceutical composition comprising, in combination, a peroxidase and an anti-singlet oxygen agent
US5554647A (en) Method and compositions for treatment and/or prevention of skin damage and aging
US6468564B1 (en) Topical compositions containing lotus for skin treatment
US4474763A (en) Skin preparation
US6281203B1 (en) Cosmetic and/or dermatological composition containing salicyclic acid derivative and its use
US5885595A (en) Cosmetic composition with a retinol fatty acid ester
US5407675A (en) Method and composition for use on the scalp and eyebrow region of a subject
US5571503A (en) Anti-pollution cosmetic composition
US6866856B2 (en) Compositions and delivery methods for the treatment of wrinkles, fine lines and hyperhidrosis
US5720963A (en) Barrier disruption treatments for structurally deteriorated skin
US5741496A (en) Process for the treatment of skins having dry areas and greasy areas
US20050281766A1 (en) Method of improving the aesthetic appearance of epithelia
US20030026820A1 (en) Use of a compositon containing an effective quantity of at least one ion chelating agent for increasing the tolerance threshold of a sensitive or intolerant skin
US5006331A (en) Compositions and method of strengthening hair
US5788972A (en) Product for topical application containing a lipase and an active ingredient precursor
US6007796A (en) Cosmetic self-tanning agent having a sunscreen effect
WO2002015860A1 (en) Topical antioxidant having vitamin c and method of combination with topical agent by user
US5043356A (en) Composition and method for rejuvenating skin using vitamin A propionate
US20060182794A1 (en) Stabilized compositions for topical administration and methods of making same
JPH08333260A (en) Skin preparation for external use
US5256403A (en) Composition and method for protecting the skin from UV-rays
US20050238730A1 (en) Compositions comprising an ethanolamine derivative and organic metal salts
WO2001034099A1 (en) Soy depigmenting and skin care compositions
JP2003306419A (en) Cosmetic
FR2798590A1 (en) Using Alverine to reduce wrinkles