GB2219999A - Substituted 5-pyrimidinecarboxamides and treatment of leukemia - Google Patents

Substituted 5-pyrimidinecarboxamides and treatment of leukemia Download PDF

Info

Publication number
GB2219999A
GB2219999A GB8815055A GB8815055A GB2219999A GB 2219999 A GB2219999 A GB 2219999A GB 8815055 A GB8815055 A GB 8815055A GB 8815055 A GB8815055 A GB 8815055A GB 2219999 A GB2219999 A GB 2219999A
Authority
GB
United Kingdom
Prior art keywords
pyrimidinecarboxamide
oxo
hydroxy
tetrahydro
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB8815055A
Other languages
English (en)
Other versions
GB8815055D0 (en
Inventor
Arthur D Brewer
John A Minatelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Uniroyal Ltd Canada
Uniroyal Chemical Co Inc
Original Assignee
Uniroyal Ltd Canada
Uniroyal Chemical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniroyal Ltd Canada, Uniroyal Chemical Co Inc filed Critical Uniroyal Ltd Canada
Publication of GB8815055D0 publication Critical patent/GB8815055D0/en
Publication of GB2219999A publication Critical patent/GB2219999A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB8815055A 1988-07-14 1988-06-24 Substituted 5-pyrimidinecarboxamides and treatment of leukemia Withdrawn GB2219999A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE8800818A BE1001263A4 (fr) 1988-07-14 1988-07-14 Procede en vue de provoquer la regression de la leucemie et l'inhibition de la croissance des tumeurs chez les mammiferes.

Publications (2)

Publication Number Publication Date
GB8815055D0 GB8815055D0 (en) 1988-08-03
GB2219999A true GB2219999A (en) 1989-12-28

Family

ID=3883532

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8815055A Withdrawn GB2219999A (en) 1988-07-14 1988-06-24 Substituted 5-pyrimidinecarboxamides and treatment of leukemia

Country Status (3)

Country Link
BE (1) BE1001263A4 (zh)
FR (1) FR2628869A1 (zh)
GB (1) GB2219999A (zh)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2174391A (en) * 1985-04-22 1986-11-05 Uniroyal Chem Co Inc 5-pyrimidinecarboxamides and treatment of leukemia and tumours therewith

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2174391A (en) * 1985-04-22 1986-11-05 Uniroyal Chem Co Inc 5-pyrimidinecarboxamides and treatment of leukemia and tumours therewith

Also Published As

Publication number Publication date
BE1001263A4 (fr) 1989-09-05
FR2628869A1 (zh) 1989-09-22
GB8815055D0 (en) 1988-08-03

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)