GB2120662B - New azepinoindoles their production and pharmaceutical compositions containing them - Google Patents

New azepinoindoles their production and pharmaceutical compositions containing them

Info

Publication number
GB2120662B
GB2120662B GB08312159A GB8312159A GB2120662B GB 2120662 B GB2120662 B GB 2120662B GB 08312159 A GB08312159 A GB 08312159A GB 8312159 A GB8312159 A GB 8312159A GB 2120662 B GB2120662 B GB 2120662B
Authority
GB
United Kingdom
Prior art keywords
azepinoindoles
new
production
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08312159A
Other languages
English (en)
Other versions
GB2120662A (en
GB8312159D0 (en
Inventor
Fulvio Gadient
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB8312159D0 publication Critical patent/GB8312159D0/en
Publication of GB2120662A publication Critical patent/GB2120662A/en
Application granted granted Critical
Publication of GB2120662B publication Critical patent/GB2120662B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
GB08312159A 1982-05-06 1983-05-04 New azepinoindoles their production and pharmaceutical compositions containing them Expired GB2120662B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH2806/82A CH649553A5 (de) 1982-05-06 1982-05-06 Azepinoindole und verfahren zu deren herstellung.

Publications (3)

Publication Number Publication Date
GB8312159D0 GB8312159D0 (en) 1983-06-08
GB2120662A GB2120662A (en) 1983-12-07
GB2120662B true GB2120662B (en) 1985-09-11

Family

ID=4242007

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08312159A Expired GB2120662B (en) 1982-05-06 1983-05-04 New azepinoindoles their production and pharmaceutical compositions containing them

Country Status (17)

Country Link
JP (1) JPS58203993A (it)
AU (1) AU1425683A (it)
BE (1) BE896590A (it)
CH (1) CH649553A5 (it)
DE (1) DE3315467A1 (it)
DK (1) DK199883A (it)
ES (1) ES8502440A1 (it)
FI (1) FI831475L (it)
FR (1) FR2526434A1 (it)
GB (1) GB2120662B (it)
HU (1) HU189275B (it)
IL (1) IL68576A0 (it)
IT (1) IT1197644B (it)
NL (1) NL8301552A (it)
PT (1) PT76632B (it)
SE (1) SE8302554L (it)
ZA (1) ZA833266B (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU193083B (en) * 1984-02-22 1987-08-28 Sandoz Ag Process for preparing diazepinoindole derivatives further pharmaceutical compositions containing such compounds
AU582564B2 (en) * 1985-02-20 1989-04-06 Sandoz Ltd. 2,3,4,5-tetrahydro-11-phenyl-1H-``1,4``diazepino``1,7-a`` indoles, their production and pharmaceutical compositions containing them
JP2004509893A (ja) * 2000-09-20 2004-04-02 ファルマシア・アンド・アップジョン・カンパニー 置換型アゼピノ［４，５ｂ］インドリン誘導体
JP2005526691A (ja) 2001-08-08 2005-09-08 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 治療剤１Ｈ−ピリド［４，３−ｂ］インドール
WO2007084622A2 (en) * 2006-01-19 2007-07-26 Athersys, Inc. Thiophenyl and pyrrolyl azepines as serotonin 5-ht2c receptor ligands and uses thereof
JP5501251B2 (ja) 2008-01-11 2014-05-21 アルバニー モレキュラー リサーチ， インコーポレイテッド Ｍｃｈ拮抗薬としての（１−アジノン）置換ピリドインドール類
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
EP2448585B1 (en) 2009-07-01 2014-01-01 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US8629158B2 (en) 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE12641T1 (de) * 1979-11-02 1985-04-15 Sandoz Ag Azepinindole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Also Published As

Publication number Publication date
ES522008A0 (es) 1985-01-01
FI831475A0 (fi) 1983-04-29
PT76632A (en) 1983-06-01
GB2120662A (en) 1983-12-07
SE8302554D0 (sv) 1983-05-04
CH649553A5 (de) 1985-05-31
PT76632B (en) 1986-01-27
IT1197644B (it) 1988-12-06
FI831475L (fi) 1983-11-07
JPS58203993A (ja) 1983-11-28
ZA833266B (en) 1984-12-24
DK199883A (da) 1983-11-07
DK199883D0 (da) 1983-05-04
SE8302554L (sv) 1983-11-07
DE3315467A1 (de) 1983-11-17
BE896590A (fr) 1983-10-28
IT8348232A0 (it) 1983-05-06
FR2526434A1 (fr) 1983-11-10
HU189275B (en) 1986-06-30
AU1425683A (en) 1983-11-10
ES8502440A1 (es) 1985-01-01
NL8301552A (nl) 1983-12-01
IL68576A0 (en) 1983-09-30
GB8312159D0 (en) 1983-06-08

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee